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,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,#,第一节 人白细胞分化抗原,(Chapter 1 Leukocyte Differentiation Antigen),第一节 人白细胞分化抗原(Chapter 1 Leukoc,1,Leukocyte Differentiation Antigen,Definition,: Leukocyte differentiation antigens,are cell surface molecules which may appear on,or disappear from cell membrane when stem,cell differentiate into different lineage cells or,when blood cells are in maturational stages and,activation status,Leukocyte Differentiation Anti,2,白细胞分化抗原的概念,白细胞分化抗原主要是指造血干细胞在,分化成熟为不同谱系、各个谱系分化不,同阶段,以及成熟细胞活化过程中,出,现或消失的细胞表面分子。,白细胞分化抗原的概念白细胞分化抗原主要是指造血干细胞在,3,结构:,大都是跨膜的糖蛋白,含胞膜外区、跨膜区和胞质区;,分类:,根据胞膜外区结构特点,可分为不同的家族或超家族,常见的有免疫球蛋白超家族、细胞因子受体家族、,C,型凝集素超家族、整合素家族、肿瘤坏死因子超家族和肿瘤坏死因子受体超家族等;按其执行的功能,主要可分为受体、共刺激(或抑制)分子以及黏附分子等;,结构:大都是跨膜的糖蛋白,含胞膜外区、跨膜区和胞质区;,4,CD (Cluster of Differentiation),Definition,: All of the monoclonal antibodies that react with a particular membrane molecule are grouped together as a cluster of differentiation.,CD is the nomenclature of human leukocyte differentiation antigens.,CD (Cluster of Differentiation,5,应用以单克隆抗体鉴定为主的方法,将,来自不同实验室的单克隆抗体所识别的,同一种分化抗原归为同一个分化群,简,称,CD,(,cluster of differentiation,),。,CD,的概念,应用以单克隆抗体鉴定为主的方法,将CD的概念,6,第二节 黏附分子,(Chapter 2 Adhesion Molecule),第二节 黏附分子(Chapter 2 Adhesion,7,Cell Adhesion Molecule (CAM),Definition:,The molecules that mediate contacting and binding between cells or between cells and extracellular matrix are referred to as cell adhesion molecules.,Play the roles in the form of receptor-ligand binding.,Participate in cell recognition, activation, signal transduction, proliferation, differentiation, migration and so on.,Cell Adhesion Molecule (CAM)De,8,概念:,细胞黏附分子是众多介导细胞间或细胞与细胞外基质间相互接触和结合分子的统称。,以受体配体结合的形式发挥作用;,参与细胞的识别,细胞的活化和信号转导,细胞的增殖与分化,细胞的伸展与移动,是免疫应答、炎症发生、凝血、肿瘤转移以及创伤愈合等一系列重要生理和病理过程的分子基础;,细胞粘附分子,(,cell adhesion molecules,,,CAM,),概念:细胞黏附分子是众多介导细胞间或细胞与细胞外基质间相互接,9,分类,(Classification),整合素家族,(intergrin family),选择素家族,(selectin family),免疫球蛋白超家族,(immunoglobulin superfamily),粘蛋白样血管地址素,(mucinlike molecule family),钙粘蛋白家族,(cadherin family),尚未归类的分子,(ungrouped molecules),分类(Classification)整合素家族(interg,10,一、整合素家族,(intergrin family),主要介导细胞与细胞外基质的黏附,,使细胞得以附着而形成整体。,一、整合素家族(intergrin family)主要介导细,11,白细胞分化抗原和黏附分子双语课件,12,白细胞分化抗原和黏附分子双语课件,13,二、选择素家族,(selectin family),有,L,、,P,和,E,选择素三个成员。,家族各成员胞膜外区结构相似,均由,C,型凝集素样(,CL,)结构域、表皮生长因子(,EGF,)样结构域和补体调节蛋白(,CCP,)结构域组成。其中,CL,结构域 是选择素结合配体部位。,识别一些寡糖基团:主要是唾液酸化的路易斯寡糖,(,sialyl-Lweis,x,,,sLe,x,即,CD15s,)或类似结构分子。,二、选择素家族(selectin family)有L、P和E,14,白细胞分化抗原和黏附分子双语课件,15,Functions of CAM,Co-receptors and costimulatory molecules in immune cells recognition.,Interaction of leukocytes with vascular endotheliocytes during the inflammatory response.,Lymphocyte homing.,Functions of CAMCo-receptors a,16,免疫细胞识别中的辅助受体和协同刺激或抑制信号;,称CD(cluster of differentiation)。,are cell surface molecules which may appear on,同阶段,以及成熟细胞活化过程中,出,使细胞得以附着而形成整体。,Cell Adhesion Molecule (CAM),细胞粘附分子 (cell adhesion molecules,CAM),尚未归类的分子(ungrouped molecules),Play the roles in the form of receptor-ligand binding.,称CD(cluster of differentiation)。,分类(Classification),分化成熟为不同谱系、各个谱系分化不,按其执行的功能,主要可分为受体、共刺激(或抑制)分子以及黏附分子等;,细胞粘附分子 (cell adhesion molecules,CAM),现或消失的细胞表面分子。,Functions of CAM,粘蛋白样血管地址素(mucinlike molecule family),分类(Classification),按其执行的功能,主要可分为受体、共刺激(或抑制)分子以及黏附分子等;,按其执行的功能,主要可分为受体、共刺激(或抑制)分子以及黏附分子等;,免疫细胞识别中的辅助受体和协同刺激或抑制信号;,17,白细胞分化抗原和黏附分子双语课件,18,白细胞分化抗原和黏附分子双语课件,19,E,E,IL-8,受体,IL-8,EEIL-8受体IL-8,20,白细胞分化抗原和黏附分子双语课件,21,三、粘附分子的功能,免疫细胞识别中的辅助受体和协同刺激或抑制信号;,炎症过程中白细胞与血管内皮细胞黏附;,淋巴细胞归巢,三、粘附分子的功能免疫细胞识别中的辅助受体和协同刺激或抑制信,22,第三节,CD,和黏附分子及其单克隆抗体的临床应用,(,Chapter 3 Clinical Application),第三节 CD和黏附分子及其单克隆抗体的临床应用(Chapt,23,阐明发病机制,在疾病诊断中的应用,在疾病预防和治疗中的应用,阐明发病机制,24,应用以单克隆抗体鉴定为主的方法,将,来自不同实验室的单克隆抗体所识别的,同一种分化抗原归为同一个分化群,简,称,CD,(,cluster of differentiation,),。,CD,的概念,应用以单克隆抗体鉴定为主的方法,将CD的概念,25,第二节 黏附分子,(Chapter 2 Adhesion Molecule),第二节 黏附分子(Chapter 2 Adhesion,26,or disappear from cell membrane when stem,二、选择素家族(selectin family),Play the roles in the form of receptor-ligand binding.,免疫球蛋白超家族(immunoglobulin superfamily),白细胞分化抗原主要是指造血干细胞在,Functions of CAM,免疫细胞识别中的辅助受体和协同刺激或抑制信号;,分化成熟为不同谱系、各个谱系分化不,称CD(cluster of differentiation)。,称CD(cluster of differentiation)。,分类(Classification),Leukocyte Differentiation Antigen,Functions of CAM,使细胞得以附着而形成整体。,现或消失的细胞表面分子。,尚未归类的分子(ungrouped molecules),免疫细胞识别中的辅助受体和协同刺激或抑制信号;,第三节 CD和黏附分子及其单克隆抗体的临床应用(Chapter 3 Clinical Application),Definition: Leukocyte differentiation antigens,when blood cells are in maturational stages and,Cell Adhesion Molecule (CAM),Definition:,The molecules that mediate contacting and binding between cells or between cells and extracellular matrix are referred to as cell adhesion molecules.,Play the roles in the form of receptor-ligand binding.,Participate in cell recognition, activation, signal transduction, proliferation, differentiation, migration and so on.,or disappear from cell membran,27,概念:,细胞黏附分子是众多介导细胞间或细胞与细胞外基质间相互接触和结合分子的统称。,以受体配体结合的形式发挥作用;,参与细胞的识别,细胞的活化和信号转导,细胞的增殖与分化,细胞的伸展与移动,是免疫应答、炎症发生、凝血、肿瘤转移以及创伤愈合等一系列重要生理和病理过程的分子基础;,细胞粘附分子,(,cell adhesion molecules,,,CAM,),概念:细胞黏附分子是众多介导细胞间或细胞与细胞外基质间相互接,28,白细胞分化抗原和黏附分子双语课件,29,第二节 黏附分子(Chapter 2 Adhesion Molecule),参与细胞的识别,细胞的活化和信号转导,细胞的增殖与分化,细胞的伸展与移动,是免疫应答、炎症发生、凝血、肿瘤转移以及创伤愈合等一系列重要生理和病理过程的分子基础;,分类(Classification),称CD(cluster of differentiation)。,Interaction of leukocytes with vascular endotheliocytes during the inflammatory response.,现或消失的细胞表面分子。,免疫球蛋白超家族(immunoglobulin superfamily),第三节 CD和黏附分子及其单克隆抗体的临床应用(Chapter 3 Clinical Application),Definition: The molecules that mediate contacting and binding between cells or between cells and extracellular matrix are referred to as cell adhesion molecules.,家族各成员胞膜外区结构相似,均由C型凝集素样(CL)结构域、表皮生长因子(EGF)样结构域和补体调节蛋白(CCP)结构域组成。,分类(Classification),or disappear from cell membrane when stem,使细胞得以附着而形成整体。,分类(Classification),二、选择素家族(selectin family),按其执行的功能,主要可分为受体、共刺激(或抑制)分子以及黏附分子等;,整合素家族(intergrin family),使细胞得以附着而形成整体。,尚未归类的分子(ungrouped molecules),主要介导细胞与细胞外基质的黏附,,按其执行的功能,主要可分为受体、共刺激(或抑制)分子以及黏附分子等;,一、整合素家族(intergrin family),白细胞分化抗原主要是指造血干细胞在,同一种分化抗原归为同一个分化群,简,称CD(cluster of differentiation)。,来自不同实验室的单克隆抗体所识别的,称CD(cluster of differentiation)。,Lymphocyte homing.,二、选择素家族(selectin family),称CD(cluster of differentiation)。,Play the roles in the form of receptor-ligand binding.,现或消失的细胞表面分子。,参与细胞的识别,细胞的活化和信号转导,细胞的增殖与分化,细胞的伸展与移动,是免疫应答、炎症发生、凝血、肿瘤转移以及创伤愈合等一系列重要生理和病理过程的分子基础;,Definition: All of the monoclonal antibodies that react with a particular membrane molecule are grouped together as a cluster of differentiation.,分类(Classification),Functions of CAM,Definition: Leukocyte differentiation antigens,同阶段,以及成熟细胞活化过程中,出,Functions of CAM,使细胞得以附着而形成整体。,结构:大都是跨膜的糖蛋白,含胞膜外区、跨膜区和胞质区;,分类(Classification),同一种分化抗原归为同一个分化群,简,白细胞分化抗原主要是指造血干细胞在,or disappear from cell membrane when stem,Definition: Leukocyte differentiation antigens,分类(Classification),Play the roles in the form of receptor-ligand binding.,家族各成员胞膜外区结构相似,均由C型凝集素样(CL)结构域、表皮生长因子(EGF)样结构域和补体调节蛋白(CCP)结构域组成。,Lymphocyte homing.,when blood cells are in maturational stages and,CD (Cluster of Differentiation),Cell Adhesion Molecule (CAM),免疫细胞识别中的辅助受体和协同刺激或抑制信号;,称CD(cluster of differentiation)。,Definition: The molecules that mediate contacting and binding between cells or between cells and extracellular matrix are referred to as cell adhesion molecules.,概念:细胞黏附分子是众多介导细胞间或细胞与细胞外基质间相互接触和结合分子的统称。,分类(Classification),Definition: Leukocyte differentiation antigens,细胞粘附分子 (cell adhesion molecules,CAM),现或消失的细胞表面分子。,称CD(cluster of differentiation)。,Definition: Leukocyte differentiation antigens,Functions of CAM,Leukocyte Differentiation Antigen,Play the roles in the form of receptor-ligand binding.,来自不同实验室的单克隆抗体所识别的,Play the roles in the form of receptor-ligand binding.,白细胞分化抗原主要是指造血干细胞在,同一种分化抗原归为同一个分化群,简,cell differentiate into different lineage cells or,概念:细胞黏附分子是众多介导细胞间或细胞与细胞外基质间相互接触和结合分子的统称。,称CD(cluster of differentiation)。,主要介导细胞与细胞外基质的黏附,,分类:根据胞膜外区结构特点,可分为不同的家族或超家族,常见的有免疫球蛋白超家族、细胞因子受体家族、C型凝集素超家族、整合素家族、肿瘤坏死因子超家族和肿瘤坏死因子受体超家族等;,概念:细胞黏附分子是众多介导细胞间或细胞与细胞外基质间相互接触和结合分子的统称。,or disappear from cell membrane when stem,使细胞得以附着而形成整体。,来自不同实验室的单克隆抗体所识别的,Functions of CAM,第二节 黏附分子(Chapter 2 Adhesion,30,
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