抗菌药物使用强度计算(附成人抗菌药物DDD值)

.抗菌药物使用强度的计算WHO在1969年制定了解剖-治疗-化学的药物分类系统（anatomical therapeutic chemical，ATC），确定了将限定日剂量（defined daily dose，DDD）作为用药频度分析的单位。并给其下定义为：用于主要治疗目的的成人的药物平均日剂量。以DDD作为测量单位，较以往单纯的药品金额和消耗量更合理，不会受到药品销售价格、包装剂量以及各种药物每日剂量不同的影响，解决了因为不同药物一次用量不同、一日用药次数不同而无法比较的问题，可以较好地反映出药物的使用频度。DDD 是一个比值，同类药物和不同类药物的DDD可以进行数值上的比较，某药的DDD数值大，说明用药频度高，用药强度大，对该药的选择倾向性大。DDD (defined daily dose)：限定日剂量。中国药典（2005年版）、新编药物学（第16版）DDD作为用药频度分析单位，不受治疗分类、剂型和不同人群的限制。药品的总剂量，是指对同一品种、不同规格、不同厂家药品分别计算其总剂量（g），最后求和得到该品种消耗的总剂量（g）。DDDs：用药频度。DDDs=该药年销售总量（g）该药的DDD值。DDDs可反映不同年度的用药动态和用药结构，DDDs越大，说明该药的使用频率越高。DDDc：限定日费用。DDDc该药年销售总金额（元）该药的DDDs值。DDDc代表药品的总价格水平，表示患者应用该药的平均日费用。DDDc越大，表示患者的经济负担越重。DUI(drug utilization index)药物利用指数，是以DDDs除以实际用药天数，可作为判别临床用药是否合理的标准。若DUI大于1.0，说明医生日剂量大于DDD，用药不合理。具体计算方法：采用WHO推荐的限定日剂量(Defined Daily Dose，DDD)方法，DDD值根据中国药典临床用药须知2005年版、新编药物学第17版及药品说明书并结合临床用药的习惯确定。用药频度(DDDs)=年消耗药品量/DDD，抗菌药物使用强度(Antibiotics Use DensityAUD)以平均每日每百张床位所消耗抗菌药物的DDD数(即DDD/100人天)表示，其值=(DDDs/用药总人天数)x100，可以测算住院人群暴露于抗菌药物的广度、强度。抗菌药物使用强度表达方式：抗菌药物使用强度=抗菌药物消耗量（累计DDD数）*100/（同期收治患者人天数）注：同期收治患者人天数=同期出院患者人数同期患者平均住院天数或1DDDs（用药频度）表达方式： 某药一定时期销售总量：是指对同一品种、不同规格、不同厂家，分别计算同期其销售总量（g)，最后求和得到该品种消耗的总量（g）DDD(defined daily dose)：成人限定日剂量。2.抗菌药物使用强度表达方式： 如计算某医院抗菌药物使用强度，它的抗菌药物消耗量（累计DDD数）即为该医院住院患者消耗的所有抗菌药物DDDs相加；计算某科室抗菌药物使用强度，它的抗菌药物消耗量（累计DDD数）为该科室消耗的所有抗菌药物DDDs相加。 同期收治患者人天数=同期出院患者人数同期住院患者平均住院天数 成人抗菌药物DDD值 药品名称 规格单位单剂量剂量单位DDD值单位DDD青霉素钠注射剂1.6MU支1.600 MU克3.6g青霉素钠注射剂4MU支4.000 MU克3.6g青霉素钠注射剂0.8MU支0.800 MU克3.6g青霉素片0.125g片0.125 g克2.0g青霉素片0.25g片0.250 g克2.0g苯唑西林钠注射剂0.5g支0.500 g克2.0g苯唑西林钠注射剂1.0g支1.000 g克2.0g氯唑西林胶囊0.125g粒0.125 g克2.0g氯唑西林胶囊0.25g粒0.250 g克2.0g氯唑西林胶囊0.5g粒0.500 g克2.0g氯唑西林颗粒剂50mg包50.000 mg克2.0g氯唑西林注射剂0.5g支0.500 g克2.0g氟氯西林胶囊0.125g片0.125 g克2.0g氟氯西林注射剂0.5g支0.500 g克2.0g氟氯西林注射剂1.0g支1.000 g克2.0g氨苄西林钠胶囊0.25g粒0.250 g克2.0g氨苄西林钠注射剂0.5g支0.500 g克2.0g阿莫西林胶囊0.25g粒0.250 g克1.0g阿莫西林胶囊0.5g粒0.500 g克1.0g阿莫西林干糖浆125mg袋125.000 mg克1.0g阿莫西林颗粒125mg袋125.000 mg克1.0g阿莫西林注射剂0.5g支0.500 g克1.0g阿莫西林注射剂2.0g支2.000 g克1.0g阿莫西林片0.25g片0.250 g克1.0g哌拉西林钠注射剂0.5g支0.500 g克14.0g哌拉西林钠注射剂1.0g支1.000 g克14.0g哌拉西林钠注射剂2.0g支2.000 g克14.0g哌拉西林钠注射剂3.0g支3.000 g克14.0g替卡西林钠注射剂1.0g支1.000 g克15.0g替卡西林钠注射剂3.0g支3.000 g克15.0g替卡西林钠注射剂6.0g支6.000 g克15.0g美西林钠注射剂0.5g支0.500 g克1.2g美西林钠注射剂1.0g支1.000 g克1.2g美洛西林钠注射剂1.0g支1.000 g克6.0g美洛西林钠注射剂2.0g支2.000 g克6.0g阿洛西林钠注射剂1.0g支1.000 g克12.0g阿洛西林钠注射剂2.0g支2.000 g克12.0g阿洛西林钠注射剂3.0g支3.000 g克12.0g阿洛西林钠注射剂4.0g支4.000 g克12.0g普鲁卡因青霉素注射剂0.4MU支0.400 MU克0.6g普鲁卡因青霉素注射剂0.8MU支0.800 MU克0.6g苄星青霉素注射剂1.2MU支1.200 MU克3.6g羧苄西林钠注射剂1.0g支1.000 g克12.0g磺苄西林钠注射剂1.0g支1.000 g克15.0g磺苄西林钠注射剂2.0g支2.000 g克15.0g磺苄西林钠注射剂5.0g支5.000 g克15.0g呋布西林钠注射剂0.5g支0.500 g克6.0g奈夫西林钠胶囊0.25g粒0.250 g克3.0g奈夫西林注射剂1.0g支1.000 g克5.0g双氯西林钠胶囊0.25g粒0.250 g克2.0g阿帕西林钠注射剂1.0g支1.000 g克8.0g阿扑西林钠注射剂0.5g支0.500 g克3.0g匹美西林钠胶囊0.25g粒0.250 g克0.6g仑氨西林片0.25g粒0.250 g克0.8g阿莫西林氟氯西林胶囊0.25g粒0.250 g克1.5g阿莫西林氟氯西林钠注射剂0.5g支0.500 g克5.0g氨苄西林氯唑西林钠注射剂0.5g支0.500 g克3.0g氨苄西林氯唑西林钠注射剂1.0g支1.000 g克3.0g阿莫西林双氯西林钠胶囊0.375g粒0.375 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mg克0.14g巴龙霉素片0.1g片0.100 g克3.0g巴龙霉素片0.25g片0.250 g克3.0g氯霉素胶囊0.05g支0.050 g克3.0g氯霉素滴眼液0.02g:8ml支0.020 g克氯霉素注射液0.25g支0.250 g克3.0g氯霉素阴道片0.05g片0.050 g克复方氯霉素洗剂100ml瓶100.000 ml甲砜霉素片0.25g片0.250 g克1.5g四环素眼膏2.0g支2.000 g克四环素可的松软膏2.0g支2.000 g克四环素片0.25g片0.250 g克1.0g土霉素片0.25g片0.250 g克1.0g多西环素注射剂0.1g支0.100 g克0.1g多西环素片0.1g片0.100 g克0.1g米诺环素胶囊0.05g粒0.050 g克0.2g米诺环素片0.05g片0.050 g克0.2g米诺环素片0.1g片0.100 g克0.2g胍甲环素片0.1g片0.100 g克1.2g美他环素片0.1g片0.100 g克0.6g红霉素注射剂0.25g支0.250 g克1.0g红霉素注射剂0.3g支0.300 g克1.0g红霉素软膏10.0g支10.000 g克红霉素软膏4.0g支4.000 g克红霉素眼膏2.0g支2.000 g克红霉素眼膏2.5g支2.500 g克红霉素片（肠溶）0.125g片0.125 g克1.0g红霉素片（肠溶）0.25g片0.250 g克1.0g红霉素片（肠溶）0.725g片0.725 g克1.0g琥乙红霉素片0.125g片0.125 g克2.0g罗红霉素胶囊0.15g片0.150 g克0.3g罗红霉素片0.05g片0.050 g克0.3g罗红霉素片0.075g片0.075 g克0.3g罗红霉素片0.15g片0.150 g克0.3g克拉霉素胶囊0.25g片0.250 g克0.5g克拉霉素颗粒剂0.0375g包0.037 g克0.5g克拉霉素注射剂0.3g支0.300 g克1.0g克拉霉素注射剂0.6g支0.600 g克1.0g克拉霉素片0.05g片0.050 g克0.5g克拉霉素片0.125g片0.125 g克0.5g克拉霉素片0.25g片0.250 g克0.5g克拉霉素片0.5g片0.500 g克0.5g阿奇霉素胶囊0.25g片0.250 g克0.3g阿奇霉素颗粒剂0.1g包0.100 g克0.3g阿奇霉素颗粒剂0.25g包0.250 g克0.3g阿奇霉素注射剂0.125g支0.125 g克0.5g阿奇霉素注射剂0.1g支0.100 g克0.5g阿奇霉素注射剂0.25g支0.250 g克0.5g阿奇霉素注射剂0.2g支0.200 g克0.5g阿奇霉素注射剂0.5g支0.500 g克0.5g阿奇霉素干混悬剂0.1g包0.100 g克0.3g阿奇霉素片0.25g片0.250 g克0.3g吉他霉素注射剂0.2g支0.200 g克1.0g吉他霉素片0.1g片0.100 g克1.0g吉他霉素片0.1g片0.100 g克1.0g吉他霉素片0.2g片0.200 g克1.0g麦迪霉素胶囊0.1g片0.100 g克1.0g麦迪霉素片0.1g片0.100 g克1.0g交沙霉素胶囊0.2g片0.200 g克2.0g交沙霉素片0.2g片0.200 g克2.0g罗他霉素片0.1g片0.100 g克0.8g乙酰螺旋霉素片0.1g片0.100 g克3.0g依托红霉素混悬剂0.125g包0.125 g克1.5g依托红霉素注射剂0.2g支0.200 g克1.5g依托红霉素片0.125g片0.125 g克1.5g泰利霉素片0.4g片0.400 g克0.8g泰利霉素片0.8g片0.800 g克0.8g地红霉素片0.25g片0.250 g克0.5g乙酰麦迪霉素片0.1g片0.100 g克1.0g麦白霉素片0.1g片0.100 g克1.0g竹桃霉素注射剂0.2g支0.200 g克1.0g金霉素眼膏2.5g支2.500 g克环酯红霉素片0.125g片0.125 g克0.75g环酯红霉素片0.25g片0.250 g克0.75g万古霉素注射剂（稳可信）0.5g支0.500 g克2.0g去甲万古霉素注射剂0.4g支0.400 g克1.2g多粘菌素B注射剂50mg支50.000 mg克0.15g粘菌素（多粘菌素E）注射剂0.15g支0.150 Mu克3.0MU替考拉宁注射剂0.2g支0.200 g克0.4g替考拉宁注射剂0.4g支0.400 g克0.4g舒巴坦钠注射剂0.25g支0.250 g克1.0g舒巴坦钠注射剂0.5g支0.500 g克1.0g林可霉素滴眼剂0.2g:8ml支0.200 g克林可霉素注射剂0.6g支0.600 g克1.8g林可霉素片0.25g片0.250 g克1.8g克林霉素胶囊0.075mg粒0.075 g克1.2g克林霉素胶囊0.15g片0.150 g克1.2g克林霉素凝胶10.0g支10.000 g克克林霉素注射剂0.3g支0.300 g克1.8g克林霉素注射剂0.6g支0.600 g克1.8g克林霉素注射剂0.9g支0.900 g克1.8g克林霉素片0.075g片0.075 g克1.2g甲硝唑注射剂0.5g支0.500 g克1.5g甲硝唑注射剂0.915g支0.915 g克1.5g甲硝唑氯已定洗剂100ml瓶100.000 ml克甲硝唑片0.2g片0.200 g克2.0g甲硝唑阴道泡腾片0.2g片0.200 g克0.5g替硝唑胶囊0.25g粒0.250 g克2.0g替硝唑胶囊0.5g粒0.500 g克2.0g替硝唑注射剂0.4g瓶0.400 g克1.5g替硝唑注射剂0.8g瓶0.800 g克1.5g替硝唑片0.5g片0.500 g克2.0g替硝唑阴道泡腾片0.2g片0.200 g克奥硝唑注射剂0.25g瓶0.250 g克1.0g奥硝唑注射剂0.5g瓶0.500 g克1.0g奥硝唑片0.25g片0.250 g克1.5g奥硝唑片0.5g片0.500 g克1.5g塞克硝唑片0.25g片0.250 g克2.0g磷霉素注射剂2.0g支2.000 g克8.0g磷霉素注射剂3.0g支3.000 g克8.0g磷霉素注射剂4.0g支4.000 g克8.0g磷霉素钙甲氧苄啶胶囊0.15g粒0.150 g克1.5g夫西地酸注射剂0.125g支0.125 g克1.5g夫西地酸注射剂0.5g支0.500 g克1.5g夫西地酸乳膏10g支10.000 g克利福霉素钠注射剂0.25g支0.250 g克0.6g利奈唑胺注射剂0.2g:100ml支0.200 g克1.2g利奈唑胺注射剂0.4g:200ml支0.400 g克1.2g利奈唑胺注射剂0.6g:300ml支0.600 g克1.2g利奈唑胺片0.4g片0.400 g克1.2g利奈唑胺片0.6g片0.600 g克1.2g磺胺嘧啶注射剂0.4g支0.400 g克4.0g磺胺嘧啶注射剂1.0g支1.000 g克4.0g磺胺嘧啶片0.5g片0.500 g克0.6g磺胺甲噁唑片0.5g片0.500 g克2.0g柳氮磺胺吡啶片0.25g片0.250 g克2.0g柳氮磺吡啶栓0.5g粒0.500 g克复方磺胺甲噁唑(复方新诺明)0.48g:2ml支0.480 g克6.08g复方磺胺甲噁唑(复方新诺明)0.48g片0.480 g克6.08g增效联磺片0.48g片0.480 g克6.08g甲氧苄氨嘧啶注射剂0.1g支0.100 g克0.4g甲氧苄氨嘧啶（TMP）片0.1g片0.100 g克0.4g磺胺嘧啶锌软膏40g盒40.000 g克磺胺嘧啶银软膏100g盒100.000 g克磺胺嘧啶银外用散剂100g听100.000 g克磺胺二甲嘧啶注射剂0.2g支0.200 g克复方磺胺嘧啶锌涂膜250ml瓶250.000 ml克吡哌酸片0.25g片0.250 g克0.8g吡哌酸片0.5g片0.500 g克0.8g诺氟沙星（氟哌酸）胶囊0.1g片0.100 g克0.8g诺氟沙星滴眼剂24mg:8ml支24.000 mg克诺氟沙星注射剂0.1g支0.100 g克0.4g诺氟沙星（氟哌酸）片0.1g片0.100 g克0.8g诺氟沙星（氟哌酸）片0.25g片0.250 g克0.8g氧氟沙星胶囊0.1g片0.100 g克0.4g氧氟沙星滴眼剂15mg:5ml支15.000 mg克氧氟沙星滴耳剂15mg:5ml支15.000 mg克氧氟沙星注射剂0.1g支0.100 g克0.4g氧氟沙星注射剂0.2g支0.200 g克0.4g氧氟沙星注射剂0.4g支0.400 g克0.4g氧氟沙星眼膏3.5g支3.500 g克0.4g氧氟沙星片0.1g片0.100 g克0.4g左氧氟沙星胶囊0.1g片0.100 g克0.5g左氧氟沙星滴眼剂0.015g:5ml支0.015 g克左氧氟沙星滴眼剂0.024g:5ml支0.024 g克左氧氟沙星眼膏10.5mg:3.5g支0.011 g克左氧氟沙星凝胶5.0g支5.000 g克左氧氟沙星注射剂0.1g支0.100 g克0.5g左氧氟沙星注射剂0.2g支0.200 g克0.5g左氧氟沙星注射剂0.3g支0.300 g克0.5g左氧氟沙星注射剂0.5g支0.500 g克0.5g左氧氟沙星片0.1g片0.100 g克0.5g左氧氟沙星片0.5g片0.500 g克0.5g环丙沙星滴眼剂15mg:5ml支0.015 g克环丙沙星注射剂0.2g支0.200 g克0.5g环丙沙星注射剂0.4g支0.400 g克0.5g环丙沙星片0.25g片0.250 g克1.0g环丙沙星片0.5g片0.500 g克1.0g洛美沙星胶囊0.1g片0.100 g克洛美沙星胶囊0.2g片0.200 g克洛美沙星滴耳液8ml支8.000 ml克洛美沙星滴眼剂15mg:5ml支5.000 ml克洛美沙星注射剂0.1g支0.100 g克洛美沙星注射剂0.2g支0.200 g克洛美沙星注射剂0.4g支0.400 g克培氟沙星注射剂0.4g支0.400 g克0.8g培氟沙星片0.2g片0.200 g克0.8g培氟沙星片0.4g支0.400 g克0.8g芦氟沙星胶囊0.1g片0.100 g克0.2g芦氟沙星片0.2g片0.200 g克0.2g司帕沙星胶囊0.1g片0.100 g克0.2g氟罗沙星胶囊0.2g片0.200 g克0.4g氟罗沙星胶囊0.4g片0.400 g克0.4g氟罗沙星注射剂0.1g支0.100 g克0.4g氟罗沙星注射剂0.2g支0.200 g克0.4g氟罗沙星注射剂0.4g支0.400 g克0.4g莫昔沙星注射剂0.4g支0.400 g克0.4g莫昔沙星片0.4g片0.400 g克0.4g加替沙星注射剂0.1g支0.100 g克