l联合方案治疗晚期胃癌

1会计学l联合方案治疗晚期胃癌联合方案治疗晚期胃癌0 05 5101015152020252530303535404045450 01 12 23 34 4粘膜炎粘膜炎腹泻腹泻手足综合征手足综合征神经毒性神经毒性脱发脱发过敏过敏Regimen NOR(%) NC(%)PFS(m)MST(m)ELF 1329663.37.2FUP13420564.47.2FAMTX13312553.36.7P0.050.050.05JCO,2000,18(14):2648毒性1234恶心/呕吐4124100粒细胞减少3972410血小板减少201255贫血543420神经毒性151000authorregimennORTTPMSTstathopoulos 2002Taxol 175mg/m2, d1CBP AUC5, d1 q 21d 4716(34%)10mKomek2002Taxol 160mg/m2,d1DDP 60mg/m2,d1 q 21d4520(44%)7m11.2Dyoo (Asco,2001,#2262)Taxol 200mg/m2,d1CBP AUC6, d1 q 21d235(22%)43wResponse N=37Duration of response(months)PR(%)8(22)7.5(3-11+)NC(%)11(30)4(3-8)PD(%)14(38)Non-evaluable4(10)Response N=48Rate (%)CR24PR2552SD1225PD612Non-evaluble24Early death13Toxicity 1(%)2(%) 3(%)4(%)Nausea/vomit383040Diarrhea 91960mucocitis261390Neutopenia 4011Anemia 2111Thrombocytopenia 04Regimen NCRPRNCPDDF252959ECF2511077P0.050.050.050.05毒性1234恶心/呕吐4124100粒细胞减少3972410血小板减少201255贫血543420神经毒性151000