LD50计算方法之—Horn氏法(霍恩法)课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,LD,50,计算方法之,Horn,氏法,原 理,Horn,氏法，,又叫平均移动法、剂量递增法，是利用剂量对数与死亡率(反应率)的转换数(即几率单位)呈直线关系而设计的方法。,设 计 原 则,4个剂量组；,每组动物数相等；,每组4只或5只；,设计剂量时可根据化学物致死剂量范围的宽窄应用两个剂量系列，其组距分别为2.15倍和3.16倍。,根据每组动物数、组距和每组动物死亡数，即可从,Horn,氏表中查得,LD,50,及其95可信限。,优 缺 点,使用动物数少；,可直接从,Horn,氏表查出,LD,50,及其95可信限，不需计算，甚为简便。,但,LD,50,的95可信区间范围较大，方法精确度尚不够。,Horn,氏表1-1 每组4只动物，组距3.16倍,各剂量组动物死亡数,(只),剂量10.316,10,t,剂量11.00,10,t,剂量21.00,剂量23.16,剂量33.16,剂量310.0,剂量410.0,剂量431.6,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,0,0,2,4,3.16,1.636.15,10.0,5.1419.4,0,0,3,4,2.37,1.334.22,7.50,4.2213.3,0,0,4,4,1.78,5.62,0,1,1,4,3.16,1.407.14,10.0,4.4322.6,0,1,2,4,2.37,0.9845.71,7.50,3.1118.1,0,1,3,4,1.78,0.7884.01,5.62,2.4912.7,0,1,4,4,1.33,0.7502.37,4.22,2.377.50,0,2,2,4,1.78,0.6954.55,5.62,2.2014.4,0,2,3,4,1.33,0.5543.21,4.22,1.7510.2,0,2,4,4,1.00,0.5141.94,3.16,1.636.15,0,3,3,4,1.00,0.4432.26,3.16,1.407.14,1,0,2,4,3.16,1.307.67,10.0,4.1224.3,1,0,3,4,2.15,0.9594.84,6.81,3.0315.3,1,0,4,4,1.47,0.8802.45,4.64,2.787.74,1,1,1,4,3.16,1.079.36,10.0,3.3829.6,1,1,2,4,2.15,0.6497.15,6.81,2.0522.6,1,1,3,4,1.47,0.4424.87,4.64,1.4015.4,1,1,4,4,1.00,0.3382.96,3.16,1.079.30,1,2,2,4,1.47,0.3795.68,4.64,1.2018.0,1,2,3,4,1.00,0.2464.06,3.16,0.77912.8,2,0,2,4,3.16,0.83711.9,10.0,2.6537.8,2,0,3,4,1.78,0.4716.72,5.62,1.4921.2,2,0,4,4,1.00,0.2653.78,3.16,0.83711.9,2,1,1,4,3.16,0.62116.1,10.0,1.9650.9,2,1,2,4,1.78,0.27111.7,5.62,0.85836.9,2,1,3,4,1.00,0.1228.18,3.16,0.38625.9,Horn,氏表1-2 每组4只动物，组距3.16倍,各剂量组动物死亡数,(只),剂量10.316,10,t,剂量11.00,10,t,剂量21.00,剂量23.16,剂量33.16,剂量310.0,剂量410.0,剂量431.6,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,2,2,2,4,1.00,0.10010.0,3.16,0.31631.6,3,0,2,4,3.16,0.22145.2,10.0,0.700143,3,0,3,4,1.00,0.038526.0,3.16,0.12282.1,3,1,1,4,3.16,0.12282.1,10.0,0.385260.0,3,1,2,4,1.00,0.014966.9,3.16,0.0472212.0,0,0,3,3,3.16,1.079.36,10.0,3.3829.6,0,0,4,3,2.15,1.293.59,6.81,4.0811.4,0,1,2,3,3.16,0.77912.8,10.0,2.4640.6,0,1,3,3,2.15,0.6497.15,6.81,2.0522.6,0,1,4,3,1.47,0.6543.30,4.64,2.0710.4,2,2,2,3,2.15,0.5568.34,6.81,1.7626.4,0,2,3,3,1.47,0.4424.87,4.64,1.4015.4,0,2,4,3,1.00,0.412 2.43,3.16,1.307.67,0,3,3,3,1.00,0.3382.96,3.16,1.079.36,1,0,3,3,3.16,0.62116.1,10.0,1.9650.9,1,0,4,3,1.78,0.7784.01,5.62,2.4912.7,1,1,2,3,3.16,0.38625.9,10.0,1.2281.8,1,1,3,3,1.78,0.28811.0,5.62,0.91134.7,1,1,4,3,1.00,0.1965.09,3.16,0.62116.1,1,2,2,3,1.78,0.22913.8,5.62,0.72543.6,1,2,3,3,1.00,0.1228.18,3.16,0.38625.9,2,0,3,3,3.16,0.12282.1,10.0,0.385260,2,0,4,3,1.00,0.070014.3,3.16,0.22145.2,2,1,2,3,3.16,0.0472212,10.0,0.149669,2,1,3,3,1.00,0.014966.9,3.16,0.0472212,2,2,2,3,1.00,0.0100100,3.16,0.0316316,Horn,氏表1-3 每组4只动物，组距3.16倍,各剂量组动物死亡数,(只),剂量10.316,10,t,剂量11.00,10,t,剂量21.00,剂量23.16,剂量33.16,剂量310.0,剂量410.0,剂量431.6,1组,2组,3组,4组,LD,50,可 信 限,LD,50,可 信 限,0,0,4,2,3.16,0.83711.9,10.0,2.6537.8,0,1,3,2,3.16,0.38625.9,10.0,1.2281.8,0,1,4,2,1.78,0.4716.72,5.62,1.4921.2,0,2,2,2,3.16,0.31631.6,10.0,1.00100,0,2,3,2,1.78,0.27111.7,5.62,0.85836.9,0,2,4,2,1.00,0.2653.78,3.16,0.83711.9,0,3,3,2,1.00,0.196 5.09,3.16,0.62116.1,1,0,4,2,3.16,0.22145.2,10.0,0.700143,1,1,3,2,3.16,0.0472212,10.0,0.149669,1,1,4,2,1.00,0.038526.0,3.16,0.12282.1,1,2,2,2,3.16,0.0316316,10.0,0.1001000,1,2,3,2,1.00,0.014966.9,3.16,0.0472212,0,2,3,1,3.16,0.0472212,10.0,0.149669,0,2,4,1,1.00,0.070014.3,3.16,0.22145.2,0,3,3,1,1.00,0.038526.0,3.16,0.12282.1,0,1,4,1,3.16,0.12282.1,10.0,0.385260,Horn,氏表2-1 每组4只动物，组距2.15倍,各剂量组动物死亡数,(只),剂量10.464,10,t,剂量11.00,10,t,剂量22.15,10,t,剂量21.00,剂量22.15,剂量34.64,剂量32.15,剂量34.64,剂量410.0,剂量44.64,剂量410.0,剂量221.5,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,LD,50,可 信 限,0,0,2,4,2.15,1.383.36,4.64,2.987.23,10.0,6.4215.6,0,0,3,4,1.78,1.212.61,3.83,2.615.62,8.25,5.6212.1,0,0,4,4,1.47,3.16,6.81,0,1,1,4,2.15,1.253.71,4.64,2.707.99,10.0,5.8117.2,0,1,2,4,1.78,0.9893.20,3.83,2.136.89,8.25,4.5914.8,0,1,3,4,1.47,0.8532.53,3.16,1.845.44,6.81,3.9611.7,0,1,4,4,1.21,0.8251.78,2.61,1.783.83,5.62,3.838.25,0,2,2,4,1.47,0.7842.75,3.16,1.695.92,6.81,3.6412.7,0,2,3,4,1.21,0.6742.18,2.61,1.454.69,5.62,3.1310.1,0,2,4,4,1.00,0.6421.56,2.15,1.383.36,4.64,2.987.23,0,3,3,4,1.00,0.5811.72,2.15,1.253.71,4.64,2.707.99,1,0,2,4,2.15,1.193.89,4.64,2.578.38,10.0,5.5418.1,1,0,3,4,1.67,0.9732.86,3.59,2.106.16,7.74,4.5113.3,1,0,4,4,1.29,0.9181.82,2.78,1.983.91,5.99,4.268.43,1,1,1,4,2.15,1.044.44,4.64,2.259.57,10.0,4.8520.6,1,1,2,4,1.67,0.7503.71,3.59,1.618.00,7.74,3.8417.2,1,1,3,4,1.29,0.5802.87,2.78,1.256.19,5.99,2.6913.3,1,1,4,4,1.00,0.4852.06,2.15,1.044.44,4.64,2.259.57,1,2,2,4,1.29,0.5243.18,2.78,1.136.86,5.99,2.4314.8,1,2,3,4,1.00,0.3932.55,2.15,0.8465.48,4.64,1.8211.8,2,0,2,4,2.15,0.8885.23,4.64,1.9111.3,10.0,4.1224.3,2,0,3,4,1.47,0.6053.56,3.16,1.307.67,6.81,2.8116.5,2,0,4,4,1.00,0.4122.43,2.15,0.8885.23,4.64,1.9111.3,2,1,1,4,2.15,0.7286.38,4.64,1.5713.7,10.0,3.3829.6,2,1,2,4,1.47,0.4195.14,3.16,0.90311.1,6.81,1.9523.9,2,1,3,4,1.00,0.2464.06,2.15,0.5318.75,4.64,1.1418.8,Horn,氏表2-2 每组4只动物，组距2.15倍,各剂量组动物死亡数,(只),剂量10.464,10,t,剂量11.00,10,t,剂量22.15,10,t,剂量21.00,剂量22.15,剂量34.64,剂量32.15,剂量34.64,剂量410.0,剂量44.64,剂量410.0,剂量221.5,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,LD,50,可 信 限,2,2,2,4,1.00,0.2154.64,2.15,0.46410.0,4.64,1.0021.5,3,0,2,4,2.15,0.36612.7,4.64,0.78927.3,10.0,1.7058.9,3,0,3,4,1.00,0.1148.77,2.15,0.24618.9,4.64,0.52940.7,3,1,1,4,2.15,0.24618.9,4.64,0.52940.7,10.0,1.1487.7,3,1,2,4,1.00,0.060716.5,2.15,0.13135.5,4.64,0.28276.5,0,0,3,3,2.15,1.044.44,4.64,2.259.57,10.0,4.8520.6,0,0,4,3,1.67,1.192.35,3.59,2.565.05,7.74,5.5010.9,0,1,2,3,2.15,0.8465.48,4.64,1.8211.8,10.0,3.9325.5,0,1,3,3,1.67,0.7503.71,3.59,1.618.00,7.74,3.8417.2,0,1,4,3,1.29,0.7532.21,2.78,1.624.77,5.99,3.5010.3,0,2,2,3,1.67,0.6764.11,3.59,1.468.86,7.74,3.1419.1,0,2,3,3,1.29,0.5802.87,2.78,1.256.19,5.99,2.6913.3,0,2,4,3,1.00,0.5541.81,2.15,1.193.89,4.64,2.578.38,0,3,3,3,1.00,0.4852.06,2.15,1.044.44,4.64,2.259.57,1,0,3,3,2.15,0.7286.38,4.64,1.5713.7,10.0,3.3829.6,1,0,4,3,1.47,0.8532.53,3.16,1.845.44,6.81,3.9611.7,1,1,2,3,2.15,0.5318.75,4.64,1.1418.8,10.0,2.4640.6,1,1,3,3,1.47,0.4364.94,3.16,0.94010.6,6.81,2.0222.9,1,1,4,3,1.00,0.3382.96,2.15,0.7286.38,4.64,1.5713.7,1,2,2,3,1.47,0.3755.75,3.16,0.80712.4,6.81,1.7426.7,1,2,3,3,1.00,0.2464.06,2.15,0.5318.75,4.64,1.1418.8,2,0,3,3,2.15,0.24618.9,4.64,0.52940.7,10.0,1.1487.7,2,0,4,3,1.00,0.1705.89,2.15,0.36612.7,4.64,0.78927.3,2,1,2,3,2.15,0.13135.5,4.64,0.28276.5,10.0,0.607165,2,1,3,3,1.00,0.060716.5,2.15,0.13135.5,4.64,0.28276.5,2,2,2,3,1.00,0.046421.5,2.15,0.10046.4,4.64,0.215100,Horn,氏表2-3 每组4只动物，组距2.15倍,各剂量组动物死亡数,(只),剂量10.464,10,t,剂量11.00,10,t,剂量22.15,10,t,剂量21.00,剂量22.15,剂量34.64,剂量32.15,剂量34.64,剂量410.0,剂量44.64,剂量410.0,剂量221.5,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,LD,50,可 信 限,0,0,4,2,2.15,0.8885.23,4.64,1.9111.3,10.0,4.1224.3,0,1,3,2,2.15,0.5318.75,4.64,1.1418.8,10.0,2.4640.6,0,1,4,2,1.47,0.6053.56,3.16,1.307.67,6.81,2.8116.5,0,2,2,2,2.15,0.46410.0,4.64,1.0021.5,10.0,2.1546.4,0,2,3,2,1.47,0.4195.14,3.16,0.90311.1,6.81,1.9523.9,0,2,4,2,1.00,0.4122.43,2.15,0.8885.23,4.64,1.9111.3,0,3,3,2,1.00,0.3382.96,2.15,0.7286.38,4.64,1.5713.7,1,0,4,2,2.15,0.36612.7,4.64,0.78927.3,10.0,1.7058.9,1,1,3,2,2.15,0.13135.5,4.64,0.28276.5,10.0,0.607165,1,1,4,2,1.00,0.1148.77,2.15,0.24618.9,4.64,0.52940.7,1,2,2,2,2.15,0.10046.4,4.64,0.215100,10.0,0.464215,1,2,3,2,1.00,0.060716.5,2.15,0.13135.5,4.64,0.28276.5,0,2,3,1,2.15,0.13135.5,4.64,0.28276.5,10.0,0.607165,0,2,4,1,1.00,0.1705.89,2.15,0.36612.7,4.64,0.78927.3,0,3,3,1,1.00,0.1148.77,2.15,0.24618.9,4.64,0.52940.7,0,1,4,1,2.15,0.24618.9,4.64,0.52940.7,10.0,1.1487.7,Horn,氏表3-1 每组5只动物，组距3.16倍,各剂量组动物死亡数,(只),剂量10.316,10,t,剂量11.00,10,t,剂量21.00,剂量23.16,剂量33.16,剂量310.0,剂量410.0,剂量431.6,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,0,0,3,5,2.82,1.604.95,8.91,5.0715.7,0,0,4,5,2.24,1.413.55,7.08,4.4711.2,0,0,5,5,1.78,5.62,0,1,2,5,2.82,1.365.84,8.91,4.3018.5,0,1,3,5,2.24,1.084.64,7.08,3.4214.7,0,1,4,5,1.78,0.9273.41,5.62,2.9310.8,0,1,5,5,1.41,0.8912.24,4.47,2.827.08,0,2,2,5,2.24,1.014.97,7.08,3.1915.7,0,2,3,5,1.78,0.8013.95,5.62,2.5312.5,0,2,4,5,1.41,0.6822.93,4.47,2.169.25,0,2,5,5,1.12,0.6381.97,3.55,2.026.24,0,3,3,5,1.41,0.6363.14,4.47,2.019.92,0,3,4,5,1.12,0.5422.32,3.55,1.717.35,1,0,3,5,2.74,1.355.56,8.66,4.2617.6,1,0,4,5,2.05,1.113.80,6.49,3.5112.0,1,0,5,5,1.54,1.072.21,4.87,3.406.98,1,1,2,5,2.74,1.106.82,8.66,3.4821.6,1,1,3,5,2.05,0.8065.23,6.49,2.5516.5,1,1,4,5,1.54,0.6323.75,4.87,2.0011.9,1,1,5,5,1.15,0.5372.48,3.65,1.707.85,1,2,2,5,2.05,0.7405.70,6.49,2.3418.0,1,2,3,5,1.54,0.5344.44,4.87,1.6914.1,1,2,4,5,1.15,0.4083.27,3.65,1.2910.3,1,3,3,5,1.15,0.3783.53,3.65,1.2011.2,2,0,3,5,2.61,1.016.77,8.25,3.1821.4,2,0,4,5,1.78,0.7234.37,5.62,2.2913.8,Horn,氏表3-2 每组5只动物，组距3.16倍,各剂量组动物死亡数,(只),剂量10.316,10,t,剂量11.00,10,t,剂量21.00,剂量23.16,剂量33.16,剂量310.0,剂量410.0,剂量431.6,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,2,0,5,5,1.21,0.5542.65,3.83,1.758.39,2,1,2,5,2.61,0.7688.87,8.25,2.4328.1,2,1,3,5,1.78,0.4846.53,5.62,1.5320.7,2,1,4,5,1.21,0.3184.62,3.83,1.0014.6,2,2,2,5,1.78,0.4347.28,5.62,1.3723.0,2,2,3,5,1.21,0.2595.67,3.83,0.81917.9,0,0,4,4,2.74,1.275.88,8.66,4.03 18.6,0,0,5,4,2.05,1.432.94,6.49,4.53 9.31,0,1,3,4,2.74,0.9687.75,8.66,3.06 24.5,0,1,4,4,2.05,0.8435.00,6.49,2.67 15.3,0,1,5,4,1.54,0.8332.85,4.87,2.63 9.01,0,2,2,4,2.74,0.8968.37,8.66,2.8326.5,0,2,3,4,2.05,0.7115.93,6.49,2.2518.7,0,2,4,4,1.54,0.6043.92,4.87,1.9112.4,0,2,5,4,1.15,0.5682.35,3.65,1.807.42,0,3,3,4,1.54,0.5554.27,4.87,1.7613.5,0,3,4,4,1.15,0.4632.88,3.65,1.479.10,1,0,4,4,2.61,0.9537.15,8.25,3.0122.6,1,0,5,4,1.78,1.033.06,5.62,3.279.68,1,1,3,4,2.61,0.65810.4,8.25,2.0832.7,1,1,4,4,1.78,0.5285.98,5.62,1.6718.9,1,1,5,4,1.21,0.4423.32,3.83,1.4010.5,1,2,2,4,2.61,0.59411.5,8.25,1.8836.3,1,2,3,4,1.78,0.4237.48,5.62,1.3423.6,1,2,4,4,1.21,0.3054.80,3.83,0.96615.2,1,3,3,4,1.21,0.2765.33,3.83,0.87116.8,Horn,氏表3-3 每组5只动物，组距3.16倍,各剂量组动物死亡数,(只),剂量10.316,10,t,剂量11.00,10,t,剂量21.00,剂量23.16,剂量33.16,剂量310.0,剂量410.0,剂量431.6,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,2,0,4,4,2.37,0.53910.4,7.50,1.7033.0,2,0,5,4,1.33,0.4463.99,4.22,1.4112.6,2,1,3,4,0.37 ?,0.30718.3,7.50,0.97058.0,2,1,4,4,1.33,0.1879.49,4.22,0.59230.0,2,2,2,4,2.37,0.26221.4,7.50,0.83067.8,2,2,3,4,1.33,0.13713.0,4.22,0.43341.0,0,0,5,3,2.61,1.195.71,8.25,3.7718.1,0,1,4,3,2.61,0.6849.95,8.25,2.1631.5,0,1,5,3,1.78,0.7234.37,5.62,2.2913.8,0,2,3,3,2.61,0.55812.2,8.25,1.7638.6,0,2,4,3,1.78,0.4846.53,5.62,1.5320.7,0,2,5,3,1.21,0.4673.14,3.83,1.489.94,0,3,3,3,1.78,0.4347.28,5.62,1.3723.0,0,3,4,3,1.21,0.3564.12,3.83,1.1313.0,1,0,5,3,2.37,0.7937.10,7.50,2.5122.4,1,1,4,3,2.37,0.33316.9,7.50,1.0553.4,1,1,5,3,1.33,0.3035.87,4.22,0.95818.6,1,2,3,3,2.37,0.24423.1,7.50,0.77173.0,1,2,4,3,1.33,0.17210.3,4.22,0.54532.6,1,3,3,3,1.33,0.14812.1,4.22,0.46738.1,Horn,氏表4-1 每组5只动物，组距2.15倍,各剂量组动物死亡数,(只),剂量10.464,10,t,剂量11.00,10,t,剂量22.15,10,t,剂量21.00,剂量22.15,剂量34.64,剂量32.15,剂量34.64,剂量410.0,剂量44.64,剂量410.0,剂量221.5,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,LD,50,可 信 限,0,0,3,5,2.00,1.372.91,4.30,2.956.26,9.26,6.3613.5,0,0,4,5,1.71,1.262.33,3.69,2.715.01,7.94,5.8410.8,0,0,5,5,1.47,3.16,6.81,0,1,2,5,2.00,1.233.24,4.30,2.656.98,9.26,5.7015.0,0,1,3,5,1.71,1.052.78,3.69,2.275.99,7.94,4.8912.9,0,1,4,5,1.47,0.9512.27,3.16,2.054.88,6.81,4.4110.5,0,1,5,5,1.26,0.9261.71,2.71,2.003.69,5.84,4.307.94,0,2,2,5,1.71,1.012.91,3.69,2.176.28,7.94,4.6713.5,0,2,3,5,1.47,0.8622.50,3.16,1.865.38,6.81,4.0011.6,0,2,4,5,1.26,0.7752.05,2.71,1.674.41,5.84,3.609.50,0,2,5,5,1.08,0.7411.57,2.33,1.603.39,5.01,3.447.30,0,3,3,5,1.26,0.7402.14,2.71,1.594.62,5.84,3.439.95,0,3,4,5,1.08,0.6651.75,2.33,1.433.78,5.01,3.088.14,1,0,3,5,1.96,1.223.14,4.22,2.636.76,9.09,5.6614.6,1,0,4,5,1.62,1.072.43,3.48,2.315.24,7.50,4.9811.3,1,0,5,5,1.33,1.051.70,2.87,2.263.65,6.19,4.877.87,1,1,2,5,1.96,1.063.60,4.22,2.297.75,9.09,4.9416.7,1,1,3,5,1.62,0.8663.01,3.48,1.876.49,7.50,4.0214.0,1,1,4,5,1.33,0.7372.41,2.87,1.595.20,6.19,3.4211.2,1,1,5,5,1.10,0.6611.83,2.37,1.423.95,5.11,3.078.51,1,2,2,5,1.62,0.8183.19,3.48,1.766.87,7.50,3.8014.8,1,2,3,5,1.33,0.6582.70,2.87,1.425.82,6.19,3.0512.5,1,2,4,5,1.10,0.5502.20,2.37,1.194.74,5.11,2.5510.2,1,3,3,5,1.10,0.5322.32,2.37,1.134.99,5.11,2.4310.8,2,0,3,5,1.90,1.003.58,4.08,2.167.71,8.80.,4.6616.6,2,0,4,5,1.47,0.8062.67,3.16,1.745.76,6.81,3.7412.4,Horn,氏表4-2 每组5只动物，组距2.15倍,各剂量组动物死亡数,(只),剂量10.464,10,t,剂量11.00,10,t,剂量22.15,10,t,剂量21.00,剂量22.15,剂量34.64,剂量32.15,剂量34.64,剂量410.0,剂量44.64,剂量410.0,剂量221.5,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,LD,50,可 信 限,2,0,5,5,1.14,0.6741.92,2.45,1.454.13,5.28,3.138.89,2,1,2,5,1.90,0.8394.29,4.08,1.819.23,8.80,3.8919.9,2,1,3,5,1.47,0.6163.50,3.16,1.337.53,6.81,2.8616.2,2,1,4,5,1.14,0.4662.77,2.45,1.005.98,5.28,2.1612.9,2,2,2,5,1.47,0.5733.76,3.16,1.248.10,6.81,2.6617.4,2,2,3,5,1.14,0.4063.18,2.45,0.8756.85,5.28,1.8914.8,0,0,4,4,1.96,1.183.26,4.22,2.537.02,9.09,5.4615.1,0,0,5,4,1.62,1.272.05,3.48,2.744.42,7.50,5.909.53,0,1,3,4,1.96,0.9783.92,4.22,2.118.44,9.09,4.5418.2,0,1,4,4,1.62,0.8932.92,3.48,1.926.30,7.50,4.1413.6,0,1,5,4,1.33,0.8852.01,2.87,1.914.33,6.19,4.119.33,0,2,2,4,1.96,0.9304.12,4.22,2.008.88,9.09,4.3119.1,0,2,3,4,1.62,0.7973.28,3.48,1.727.06,7.50,15.2,0,2,4,4,1.33,0.7152.40,2.87,1.545.36,6.19,11.5,0,2,5,4,1.10,0.6861.77,2.37,1.483.80,5.11,8.19,0,3,3,4,1.33,0.6762.63,2.87,1.465.67,6.19,12.2,0,3,4,4,1.10,0.5992.02,2.37,1.294.36,5.11,9.39,1,0,4,4,1.90,0.9693.71,4.08,2.097.99,8.80,17.2,1,0,5,4,1.47,1.022.11,3.16,2.204.54,6.81,9.78,1,1,3,4,1.90,0.7574.75,4.08,1.6310.2,8.80,22.0,1,1,4,4,1.47,0.6543.30,3.16,1.417.10,6.81,15.3,1,1,5,4,1.14,0.5812.22,2.45,1.254.79,5.28,10.3,1,2,2,4,1.90,0.7065.09,4.08,1.5211.0,8.80,23.6,1,2,3,4,1.47,0.5643.82,3.16,1.218.24,6.81,17.7,1,2,4,4,1.14,0.4542.85,2.45,0.9776.13,5.28,13.2,1,3,3,4,1.14,0.4233.05,2.45,0.9126.57,5.28,1.9714.2,Horn,氏表4-3 每组5只动物，组距2.15倍,各剂量组动物死亡数,(只),剂量10.464,10,t,剂量11.00,10,t,剂量22.15,10,t,剂量21.00,剂量22.15,剂量34.64,剂量32.15,剂量34.64,剂量410.0,剂量44.64,剂量410.0,剂量221.5,1,2,3,4,LD,50,可 信 限,LD,50,可 信 限,LD,50,可 信 限,2,0,4,4,1.78,0.6624.78,3.83,1.4310.3,8.25,3.0722.2,2,0,5,4,1.21,0.5832.52,2.61,1.265.42,5.62,2.7111.7,2,1,3,4,1.78,0.4556.95,3.83,0.98015.0,8.25,2.1132.3,2,1,4,4,1.21,0.3274.48,2.61,0.7059.66,5.62,1.5220.8,2,2,2,4,1.78,0.4107.72,3.83,0.88316.6,8.25,1.9035.8,2,2,3,4,1.21,0.2665.52,2.61,0.57311.9,5.62,1.2325.6,0,0,5,3,1.90,1.123.20,4.08,2.426.89,8.80,5.2214.8,0,1,4,3,1.90,0.7774.63,4.08,1.679.97,8.80,3.6021.5,0,1,5,3,1.47,0.8062.67,3.16,1.745.76,6.81,3.7412.4,0,2,3,3,1.90,0.6735.30,4.08,1.4611.4,8.80,3.1524.6,0,2,4,3,1.47,0.6163.50,3.16,1.337.53,6.81,2.8616.2,0,2,5,3,1.14,0.6022.15,2.45,1.304.62,5.28,2.799.96,0,3,3,3,1.47,0.5733.76,3.16,1.248.10,6.81,2.6617.4,0,3,4,3,1.14,0.5032.57,2.45,1.085.54,5.28,2.3311.9,1,0,5,3,1.78,0.8563.69,3.83,1.857.96,8.25,3.9817.1,1,1,4,3,1.78,0.4816.58,3.83,1.0414.2,8.25,2.2330.5,1,1,5,3,1.21,0.4513.25,2.61,0.9727.01,5.62,2.0915.1,1,2,3,3,1.78,0.3908.11,3.83,0.84017.5,8.25,1.8137.6,1,2,4,3,1.21,0.3104.74,2.61,0.66810.2,5.62,1.4422.0,1,3,3,3,1.21,0.2795.26,2.61,0.60211.3,5.62,1.3024.4,