孟德尔随机化分析原理解析

,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,2017/10/12,#,Mendelian R,andomisation,study,Mendelian R,andomisation,study,SNPs,25OHD,Asthma,Childhood asthma,Atopic dermatitis,IgE,Confounders,(BMI,Smoking,),Pleiotropy,(eosinophils),Standardized plan in,Mendelian randomisation study,Extract interesting SNPs,Extract data of cases and controls,Two-sample MR,Potential problems and limitations of,Mendelian randomisation study,Validate SNPs,Extract interesting SNPs,P,value,10,),回归系数的平方,F,(n - 2,)/(,1 -,）,2.LD,分析 （,and D,）,dumping SNPs index SNP,3.population stratification,分析,4,. Pleiotropy,分析,(,基因图谱，遗传距离，染色体上位置以及蛋白通道,),SNPs exposures outcome,非研究暴露,5.,敏感性分析 （依次剔除功能相似，在同一基因上或附近的,SNPs,）,验证,MR,三个假设（线性回归，,Logistic,回归，,meta,分析）,分析,SNPs,与中间表型的相关性（,+,）,分析,SNPs,与已知混杂因素的相关性（,-,）,目标,SNPs,对,结局的作用必须只能通过已知的研究表型,Potential problems and limitations of Mendelian randomisation study,Non-linear associations,Weak,instruments,Linkage,disequilibrium,Population,stratification,undertake subgroup,analyses,6. Dont to,gain,mechanistic insights,操作演示,