医学免疫学课件

,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,Chapter 17 regulation of the immune response,Chapter 17 regulation of the,1,regulation of the immune response refers to the physiological feedback regulation of the host itself to the course of immune response.,The immune response, like all biological system, is subject to a variety of control mechanisms. these mechanisms restore the immune system to a resting state when responsiveness to a given antigen is no longer required. An effective immune response is an outcome of the interplay between antigen and a network of immunologically competent cells.,Positive and negative regulation,Four levels of immune regulation:,molecular, cellular ,individual &population,regulation of the immune respo,2,医学免疫学课件,3,医学免疫学课件,4,一 PTK involving activation signal transduction and PTP involving negative feedback regulation,（一）two opposing components in activation signal transduction of immunocyte,1. Phosphorylation and dephosphorylation of protein,PTKPhosphorylationpositive regulation,PTPdephosphorylationnegative regulation,Section 1 immune regulation on molecular level,一 PTK involving activation s,5,2. the function of PTK & PTP in cytoplasm rely on ITAM & ITIM,Src-PTKITAMPTK ZAP-70/SyKpositive regulation,Src-PTKITIMPTPnegative regulation,2. the function of PTK & PTP,6,（二） Two kinds of receptors existing in immunocyte whose function is contrary,1. activation receptor,ITAM，YxxL/V,2. Inhibition receptor,ITIM， I/VxYxxL，,（二） Two kinds of receptors exi,7,二 inhibition receptors on immunocytes and their clinical significance,1. T cell：CTLA-4 & PD-1,CTLA-4-CD80/CD86,immune intervention,PD-1-B7,2. B cell：FcRII-B,FcRII-B ,ITIM,二 inhibition receptors on imm,8,医学免疫学课件,9,抗BCRIgG,抗BCR的,抗BCRIgG抗BCR的,10,3. KIR & CD94/NKG2A on killer cells（CTL ， NK ）：,4.,mast cell：,。,3. KIR & CD94/NKG2A on kille,11,医学免疫学课件,12,医学免疫学课件,13,Section 2 immune regulation on cellular level,一、T lymphocyte,（一）natural regulatory T lymphocyte,CD4+CD25+foxp3+T,Section 2 immune regulation on,14,医学免疫学课件,15,（二）adaptive regulatory T lymphocyte,（二）adaptive regulatory T lymph,16,医学免疫学课件,17,医学免疫学课件,18,TGF-,TGF-,19,二 the idiotype network and immune regulation,（一）anti-idiotypic antibody and idiotype network,AgBCR、Ab -,-Ab2(AId）-Ab3-Ab4,AId: to frame of V region：Ab2,to CDR ：Ab2（antigenic internal image ）,二 the idiotype net,20,医学免疫学课件,21,（二）using anti-idiotype network to interfere immunity,（二）using anti-idiotype network,22,三 negative immune regulation by apoptosis,三 negative immune regulation,23,（一） activation induced cell death and specific immune response,1 Fas and FasL,Fas：,FasL：,activation induced cell death ，AICD,（一） activation induced cell de,24,2 . the course of AICD,DD,DED,DED,2 . the course of AICDDDDEDDE,25,3. Significance of AICD,3. Significance of AICD,26,医学免疫学课件,27,Section 3 immune regulation on individual and population level,Section 3 immune regula,28,一、regulation of neuro-endocrine-immune network,1. Neuroendocrine factor modulate immune response,2. Antibody and cytokine modulate neuroendocrine system,一、regulation of neuro-endocrin,29,医学免疫学课件,30,二、immune regulation on population level,医学免疫学课件,31,