抗生素的耐药危机(英文PPT)课件

抗生素的耐药危机(英文PPT)课件1THE ANTIBIOTIC RESISTANCE CRISISTHE 2THE ANTIBIOTIC RESISTANCE CRISIS HISTORY OF BACTERIA HISTORY OF ANTIBIOTICS RESISTANCE THE PROBLEM NOW NEVADANS FOR ANTIBIOTIC AWARENESSTHE ANTIBIOTIC HISTORY OF BA3抗生素的耐药危机(英文PPT)课件4抗生素的耐药危机(英文PPT)课件5HISTORY OF BACTERIAREPRODUCTIONBINARY FISSION CLONE OF ORIGINAL WITH SAME DNAFAST PROCESS ONE BACTERIUM CAN PRODUCE ONE BILLION CLONES IN TEN HOURSHISTORY OF BACTERIAREPRODUCTIO6HISTORY OF BACTERIAREPRODUCTIONMUTATION A CHANGE,SO THAT THE“NEW”BACTERIA IS SLIGHTLY DIFFERENT THAN THE ORIGINALHISTORY OF BACTERIAREPRODUCTIO7HISTORY OF BACTERIAREPRODUCTIONIF THE ENVIRONMENT IS RIGHT,THE“NEW”BACTERIA MAY SURVIVE BETTER AND REPRODUCE,PASSING ALONG THE MUTATIONHISTORY OF BACTERIAREPRODUCTIO8HISTORY OF ANTIBIOTICS1928 DR.FLEMING DISCOVERS PENICILLIN FROM BREAD MOLD1944 U.S.MILITARY TAKES PENICILLIN TO THE BATTLEFIELD1945 BACTERIA WITH RESISTANCE TO PENICILLIN ISOLATEDHISTORY OF ANTIBIOTICS1928 D9HISTORY OF ANTIBIOTICS1960s METHICILLIN INTRODUCED1991 29%OF STAPH AUREUS RESISTANT2001 62%OF STAPH AUREUS RESISTANTRESISTANCEHISTORY OF ANTIBIOTICS1960s 10HISTORY OF ANTIBIOTICSRESISTANCE BACTERIA MUTATE TO PROTECT THEMSELVES FROM ANTIBIOTICSHISTORY OF ANTIBIOTICSRESISTAN11HISTORY OF ANTIBIOTICSRESISTANCE THE MUTATED BACTERIA SURVIVE AFTER THE ANTIBIOTICS ARE GONEHISTORY OF ANTIBIOTICSRESISTAN12HISTORY OF ANTIBIOTICSRESISTANCE EVENTUALLY THERE ARE MORE ANTIBIOTIC-RESISTANT BACTERIA THAN NON-RESISTIANTHISTORY OF ANTIBIOTICSRESISTAN13HISTORY OF ANTIBIOTICSRESISTANCE THE MUTATED BACTERIA REPRODUCE,PASSING ALONG THE RESISTANCE TO THEIR OFFSPRINGHISTORY OF ANTIBIOTICSRESISTAN14HISTORY OF ANTIBIOTICSRESISTANCE BACTERIA CAN ALSO SWAP GENES,UNDER THE RIGHT CONDITIONS,SO DRUG-RESISTANT GERMS CAN SHARE THEIR RESISTANCE MECHANISMSHISTORY OF ANTIBIOTICSRESISTAN15THE PROBLEM NOW 1991 1999 2000 2001 1991 1999 2000 2001THE PROBLEM NOW 1991 199916THE PROBLEM NOW 2000 2001 2000 2001THE PROBLEM NOW 2000 17THE PROBLEM NOW 50%OF HOSPITAL ACQUIRED BLOODSTREAM INFECTIONS ARE CAUSED BY METHICILLIN-RESISTANT STAPH AUREUS(MRSA)70%OF NURSING HOME STAPH INFECTIONS ARE CAUSED BY MRSATHE PROBLEM NOW 50%OF HOSPIT18THE PROBLEM NOW “THERE ARE PATIENTS TODAY IN HOSPITALS FOR WHOM THERE ARE NO EFFECTIVE THERAPIES.”Gary DoernDirector of Clinical MicrobiologyUniversity of IowaTHE PROBLEM NOW “THERE ARE 19NEVADANS FOR ANTIBIOTIC AWARENESS WHO WE ARE WHAT WE HAVE DONE WHAT WE ARE DOING RESULTS HOW CAN YOU HELPNEVADANS FOR WHO WE ARE20NEVADANS FOR ANTIBIOTIC AWARENESSWHO WE AREA STATEWIDE TASK FORCE THAT HAS BEEN IN EXISTENCE SINCE FEBRUARY 20013 SUBCOMMITTEES PUBLIC AWARENESS PROVIDER EDUCATION INFECTION CONTROL AND SURVEILLANCENEVADANS FOR WHO WE AREA STATE21NEVADANS FOR ANTIBIOTIC AWARENESSWHAT WE HAVE DONEPUBLIC AWARENESSTV,RADIO SPOTS IN SPANISH AND ENGLISH AIRING 400-500 TIMES PER MONTHNEVADA LEGISLATURE PASSED A BILL SUPPORTING NAAGOVERNOR GUINN ISSUED A PROCLAMATION SUPPORTING NAANEVADANS FOR WHAT WE HAVE DONE22NEVADANS FOR ANTIBIOTIC AWARENESSWHAT WE HAVE DONEPUBLIC AWARENESSEDUCATION PROGRAMS WERE COMPLETED FOR ALL CLARK AND WASHOE COUNTY SCHOOL NURSES AND THEIR AIDESA 9TH AND 10TH GRADE SUPPLEMENTAL CURRICULUM BASED ON THE SURVIVOR SERIES IS BEING USED IN CLARK AND WASHOE COUNTIESNEVADANS FOR WHAT WE HAVE DONE23NEVADANS FOR ANTIBIOTIC AWARENESSWHAT WE HAVE DONEPUBLIC AWARENESS 10,000 BOOKMARKS HAVE BEEN DISTRIBUTED BY THE WASHOE COUNTY LIBRARY SYSTEMMAJOR PHARMACY CHAINS HAVE DISTRIBUTED 100,000 BOOKMARKSNEVADANS FOR WHAT WE HAVE DONE24NEVADANS FOR ANTIBIOTIC AWARENESSWHAT WE HAVE DONEPUBLIC AWARENESSEMERGENCY ROOMS AND QUICK-CARE CENTERS ARE DISPLAYING OUR POSTERS AND BROCHURES(SPANISH&ENGLISH)RECENT ANTIBIOTIC RESISTANCE INFORMATION HAS BEEN SENT TO ALL CLARK COUNTY CHILD CARE CENTERSNEVADANS FOR WHAT WE HAVE DONE25NEVADANS FOR ANTIBIOTIC AWARENESSWHAT WE HAVE DONEPROVIDER EDUCATIONPROVIDER PACKETS WERE SENT TO ALL PRIMARY CARE PHYSICIANS IN 2002 AND 2003A CME PROGRAM WAS CONDUCTED FOR 150 PHYSICIANS IN NORTHERN NEVADAA HOSPITALIST EDUCATION PROGRAM HAS BEEN IMPLEMENTED IN CLARK COUNTYNEVADANS FOR WHAT WE HAVE DONE26NEVADANS FOR ANTIBIOTIC AWARENESSWHAT WE HAVE DONEPROVIDER EDUCATIONPRESENTATIONS TO UMC SECOND-YEAR RESIDENTS HAVE BEEN MADEINDIVIDUAL PROVIDER OFFICE VISITS IN ELKO AND PAHRUMP HAVE BEEN COMPLETEDA PRESENTATION REGARDING NAA WAS MADE AT A CDC CONFERENCENEVADANS FOR WHAT WE HAVE DONE27NEVADANS FOR ANTIBIOTIC AWARENESSWHAT WE ARE DOINGEXPANDING EFFORTS TO IMPROVE INFECTION CONTROL AND SURVEILLANCE WITH THE CDC 12-STEP PROGRAMFINISHING DEVELOPMENT OF NAA WEB SITEDEVELOPING AND IMPLEMENTING CHILD CARE PROFESSIONAL PROGRAMINCREASING MEDICAL SCHOOL/RESIDENCY INVOLVEMENT NEVADANS FOR WHAT WE ARE DOING28NEVADANS FOR ANTIBIOTIC AWARENESSWHAT WE ARE DOINGINCREASING PHARMACY SCHOOL INVOLVEMENTEXPANDING EFFORTS TO IMPROVE INFECTION CONTROL IN LONG TERM CARE AND SKILLED NURSING FACILITIESCONTINUING MEDIA CAMPAIGN AND ALL OTHER CURRENT EFFORTS TOWARD PUBLIC AND PROVIDER EDUCATIONNEVADANS FOR WHAT WE ARE DOING29NEVADANS FOR ANTIBIOTIC AWARENESSRESULTSNumber of Antibiotic Scripts Filled per Member per MonthHPN Consolidated(Commercial and Medicare)2000 2002NEVADANS FOR RESULTSNumber of 30NEVADANS FOR ANTIBIOTIC AWARENESSCONTINUE WORKING WITH THE INFECTION CONTROL/SURVEILLANCE COMMITTEEINVITE US TO MAKE A PRESENTATION TO YOUR PHARMACY AND THERAPEUTIC COMMITTEEWORK WITH HEALTHINSIGHT IN OUR SURGICAL INFECTION PREVENTION PROGRAMHOW YOU CAN HELPNEVADANS FOR CONTINUE WORKING 31