医学免疫学课件

,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,Chapter 17 regulation of the immune response,regulation of the immune response refers to the physiological feedback regulation of the host itself to the course of immune response.,The immune response, like all biological system, is subject to a variety of control mechanisms. these mechanisms restore the immune system to a resting state when responsiveness to a given antigen is no longer required. An effective immune response is an outcome of the interplay between antigen and a network of,immunologically,competent cells.,Positive and negative regulation,Four levels of immune regulation:,molecular, cellular ,individual &population,一,PTK involving activation signal transduction and PTP involving negative feedback regulation,（一）,two opposing components in activation signal transduction of,immunocyte,1.,Phosphorylation,and,dephosphorylation,of protein,PTK,Phosphorylation,positive regulation,PTP,dephosphorylation,negative regulation,Section 1 immune regulation on molecular level,2. the function of PTK & PTP in cytoplasm rely on ITAM & ITIM,Src,-PTKITAMPTK ZAP-70/SyKpositive regulation,Src,-PTKITIMPTPnegative regulation,（二）,Two kinds of receptors existing in,immunocyte,whose function is contrary,1. activation receptor,ITAM,，,YxxL,/V,2. Inhibition receptor,ITIM,，,I/,VxYxxL,，,二,inhibition receptors on,immunocytes,and their clinical significance,1. T cell,：,CTLA-4 & PD-1,CTLA-4-CD80/CD86,immune intervention,PD-1-B7,2. B cell,：,FcRII,-B,FcRII,-B,ITIM,抗,BCRIgG,抗,BCR,的,3. KIR & CD94/NKG2A on killer cells,（,CTL,，,NK,）：,4.,mast cell,：,。,Section 2 immune regulation on cellular level,一、,T lymphocyte,（一）,natural regulatory T lymphocyte,CD4+CD25+foxp3+T,（二）,adaptive regulatory T lymphocyte,TGF-,二,the,idiotype,network and immune regulation,（一）,anti-,idiotypic,antibody and,idiotype,network,AgBCR,、,Ab,-,-Ab2(AId,）,-Ab3-Ab4,AId,: to frame of V region,：,Ab2,to CDR,：,Ab2,（,antigenic internal image,）,（二）,using anti-,idiotype,network to interfere immunity,三,negative immune regulation by apoptosis,（一）,activation induced cell death and specific immune response,1,Fas,and,FasL,Fas,：,FasL,：,activation induced cell death,，,AICD,2 . the course of AICD,DD,DED,DED,3. Significance of AICD,Section 3 immune regulation on individual and population level,一、,regulation of,neuro,-endocrine-immune network,1.,Neuroendocrine,factor modulate immune response,2. Antibody and cytokine modulate,neuroendocrine,system,二、,immune regulation on population level,