抗氧化剂让你延年益寿

Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,抗氧化劑,：,讓你延年益壽,Antioxidants: add life to your years,NuSkin presentation,Taiwan,November 3, 2007,Prof. Lester Packer,1,百歲人瑞,Centenarian,2,0,20,40,60,80,100,0,20,40,60,80,100,120,長壽人口增加後之存活率,%,Survival if % reduction in mortality at all ages occurs again,1985,存活率,1985 Survival,1900,存活率,1900 Survival,存活率,% OF POPULATION SURVIVING,年齡分布,Chronological Age,健康長壽的趨勢,Toward Healthy Aging,T.B.L. Kirkwood in Longevity: To the limits and Beyond. Ed. By J.M. Robine et.al.,Published by Springer: Heidelberg, 1997.,3,0,20,40,60,80,100,Colon,Cancer,Stroke,Coronary,Disease,Diabetes,Type 2,改變生活型態以預防疾病的發生,Diseases Avoidable by a Change in Lifestyle,Walter Willett Science 296, 695-,698: 2002,-,減少百分比,Percent avoidable,結腸癌,中風,冠狀動脈疾病,第二型糖尿病,4,前列腺癌比例,上海人,Shanghai,born,Chinese,1.7,中國人,(,居住美國, 5,年,),China born Chinese,(live in US 5,年,),China born Chinese,(live in US 5 yrs),23,在美國出生的中國人,US born Chinese,37,美國出生的高加索人,US born Caucasian,58,US,China,亞洲國家,Asian,Countries,西方國家,Western,Countries,Int.J. Cancer (2000) 85:60-7,Courtesy Emily Ho,5,氧化壓力,Oxidative Stress,自由基造成氧化壓力,Free radicals cause oxidative stress,導致組織壞死、老化及疾病的發生,Leads to tissue damage, aging and disease,6,維生素,C,及,E,Vitamins C and E,多酚類,(,類黃酮,),Polyphenols,(,Flavonoids,),),硫氫基,Thiols,：,麩胱甘肽,Glutathione,硫辛酸,Lipoic,Acid,輔酵素,Q10,Co-enzyme Q,抗氧化劑,Antioxidants,類胡蘿蔔素,Carotenoids,氧化還原循環,Redox cycling,清除自由基,Radical scavenging,7,8,9,皮膚構造,角質層,表皮層,真皮層,10,紅斑,一種典型的曬傷後發炎反應,MED,是紅斑的衡量單位。它是指少量的,UVB,照射,24,小時候後,，,在皮膚產生些微的紅斑現象的評估,。,11,12,人體角質層中的維生素,E,濃度,-,生育醇,-,生育醇,濃度,(pmol),濃度,(pmol),13,抗氧化網絡運作模式,The Antioxidant Network in Membranes,VitE,循環,Vit. E,Cycle,Q10,循環,Q,10,H,Cycle,維生素,C,循環,Vit. C,Cycle,脂質自由基,Lipid Free Radicals,LOO,LO,類胡蘿蔔素,Carotenoids,代謝,Metabolism,脂溶性環境,Fat Soluble,水溶性環境,Water Soluble,水溶性環境,Water Soluble,氧化代謝,Oxygen,Metabolism,14,蔬果中的類胡蘿蔔素,Carotenoids in fruits & vegetables,-,隱黃質,-cryptoxanthin,(,13-20%),葉黃素,Lutein,(10-20%),-,胡蘿蔔素,a-,carotene,(5-10%),-,胡蘿蔔素,b,carotene,(15-30%),玉米黃質,Zeaxanthin,(1-5%),菠菜,豌豆,青豆,白豆,綠花菜,球芽甘藍,包心菜,無頭甘藍菜,奇異果,萵苣,Spinach, Green peas, Green Beans , Lima Beans Broccoli, Brussel sprouts, Cabbage, kale, Kiwi, Lettuce,胡蘿蔔,南瓜,地瓜,杏子,洋香瓜,西瓜,Carrots, Pumpkin, Sweet Potatoes,Apricots, Cantaloupe, Watermelon,蕃茄,紅葡萄柚,Tomatoes, Pink Grapefruit,人類細胞中的類胡蘿蔔素,Carotenoids in Human Plasma,蕃茄紅素,Lycopene (20-40%),15,拉曼光譜研究,利用測量眼睛類胡蘿蔔素含量,，,來診斷老化引起的視網膜黃斑退化現象,Raman scattering studies are used to measure carotenoids in the Eye and to diagnose age-related macular degeneration,斑點,Macula,葉黃素,&,玉米黃質,Lutein & Zeoxanthin,Gellermann W, Ermakov IV, McClane RW, Bernstein PS.,Raman imaging of human macular pigments.,Optics Letters. 2002;27:833,人類視網膜,視網膜,視神經,16,C. Smidt and D.S. Burke, Nutritional Significance and Measurement of Carotenoids,Current Topics in Nutraceutical Research,2004,2, 79-91,0,20000,40000,60000,0,0.5,1,1.5,2,2.5,3,3.5,4,血清中類胡蘿蔔素總量,Total Serum Carotenoids (,g/ml),Skin Raman Intensity (n = 372),r = 0.84 (p0.0001),p0.01,p0.01,p0.01,Std. Error 44,Std. Error 38,Std. Error 61,Std. Error 106,24793,26639,29704,31507,10000,15000,20000,25000,30000,35000,1 or less,2 to 3,4 to 5,6 or more,Courtesy Stephen Poole, Pharmanex,Skin Raman Intensity,(2005 US data of 209,628 Non-Supplement Users),每日食用水果及蔬菜份數,Daily servings of fruits and vegetables,良好的生活型態增進皮膚抗氧化類胡蘿蔔素,與掃描儀之研究,Lifestyle can improve carotenoid antioxidants in skin- Scanner studies,209,628,位受試者,從未使用過營養補充品,結論：每日吃,6,份以上蔬果者，皮膚類胡蘿蔔素指數明顯增加,身體防禦指數,身體防禦指數,17,4,毫克葉黃素,4 mg Lutein,杯烹煮過的菠菜, cup of cooked spinach,1,又,1/3,根中型胡蘿蔔 或,杯南瓜,1 & 1/3 medium carrots or cup pumpkin,4,毫克,b,-,胡蘿蔔素,4 mg,b,-Carotene,4,毫克蕃茄紅素,4 mg Lycopene,1,顆中型番茄 或,茶匙番茄醬,1 medium tomato,or Tsp tomato paste,營養補充品中的類胡蘿蔔素含量與天然食物的相對份量,Carotenoids in human supplements,equivalent,to amounts in food (courtesy,KJ Yuem),18,食用營養補充品後,，血漿中總類胡蘿蔔素濃度增加,Plasma Total Carotenoid Concentration,Is increased after Supplementation,時間,日,Time, Day,D1,D15,D29,D43,D57,Plasma Total Carotenoid (,m,g/dL),0,20,40,60,80,100,120,140,160,180,Placebo,對照組,Mixed Car,綜合類胡蘿蔔素,Lutein,葉黃素,b,-Carotene,b,-,胡蘿蔔素,Lycopene,蕃茄紅素,*,*,*,*,*,*,*,*,*,*,*,*,*,*,*,*,*,*,*,Significantly different from baseline,顯著差異,*,p0.05,Courtesy KJ Yuem, et al.,血漿中總類胡蘿蔔素濃度,(mg/dL),19,食用含類胡蘿蔔素的營養補充品在慧星分析法証實,，,可以保護人類淋巴球中的,DNA,免受破壞,Carotenoid Supplementation protects against DNA Damage in human lymphocytes,The comet assay,第,57,天,Day 57,第,1,天,Day 1,35,563,位受試者,(Subject # 35563),Courtesy KJ Yuem, et al.,20,維生素,A,在健康百歲人瑞體內含量顯著比年輕人高,Vitamin A levels are increased in healthy centenarians compared to younger subjects,Vitamin A (M),100,歲,Centenarians, 60,歲,60-79,歲,80-99,歲,153,位義大利百歲人瑞,153 Italian centenarians, * p 0.0001,*,*,*,0,1,2,3,4,5,6,Christina Polidori, Eur J Clin Nutr 2007,(M),維生素,A,21,酵素,&,蛋白質的誘導物,保護抗氧化劑,Inducers of enzymes & proteins,needed for antioxidant defense,人體中類胡蘿蔔素,Carotenoids in Humans are,維生素,A,的前驅物,環狀碳氫化合物的類胡蘿蔔素,Vitamin,A precursors,cyclic hydrocarbon,carotenoids,清除自由基,Free radical scavengers,對抗氧化,protect against oxidation,22,