早产儿脑白质损伤基础与MRI评价课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,早产儿脑白质损伤研究进展,中国医科大学附属盛京医院,毛健,早产儿脑白质损伤研究进展,1,PAS 2013,PAS 2013,2,早产儿脑白质损伤基础与MRI评价课件,3,世界范围内的流行病学,世界范围内的流行病学,4,世界范围内的流行病学,Rank for,Number of preterm,Preterm blrth Number of llveblrths,births ( %of global total) rate r% of (3 of global total),preterm bIrths,1,3519118(236%,134,27200000(201%),17259078%)71%,16600000(123%),Nigeria,73597(52%,632251(47%,dstan,748142(50%,4741460(35%),dorsa,675744(45%,43188(323),5144305%,120,4300620(32%),Bangladesh,345678,424144(28%,30652(23%),48871(23%,149,2344154(17%,Democratic Repub 9,341421(23%,119,2872606(21%,f Congo,279256(19%,92%,3022823(22),Total,88mn69%),748mlan(55%),Table4: Theten countrlesw lth the highest numbers of preterm births In 2010,世界范围内的流行病学,5,lable 3. Preterm birth rates, number of preterm births by United Nations geographical region/subregion and percentage of births,cowered by the estimates in a systematic review of the worldwide incidence of preterm birth,Region/subregion,Preterm birt,Preterm birth rate,rcent,No.in10005,%,World to,1222813511,9.1-10.1,5.8,More developed countries,1014,932-1046,7.5,ess developed countries,7685,71098261,88,8.1-94,east developed countries,3891-442,11.7-133,Africa,4047,3783-4311,1-12.6,Middle,116,10.3-129,Northern,407,290523,2-112,Southem,91-255,175,146203,Asia,690,6328-7486,8.39.8,99,Eastern,650-798,3.44,South-central,39444991,10.0-12,South-eastern,1271,1062-1480,9.3-130,Westem,290601,6.8-9.9,centra,21-77,165.9,Europe,466,434498,5.867,948,LA and the caribbean,858-100,7588,Caribbean,Centra america,233-326,8.2-10.1,South amanda,52468,70-88,North americao,10.6,10.5-106,Austral ia/new zealand,2020,64,6.366,Hest of oceania,4.682,lable 3. Preterm birth rates,6,CDC-2010-Preterm distribut ion,13%,10%,口2828-31口32-33口3436,Table 23. Births, by birthweight and gestational age and by race and Hispanic origin of mother: United States, 2010,Period a gestation?,A unser Under2828-31323343637-4137383,span origin of mther,births 37 weeks wees weaks weaks week week,9933647879029.581486161.15933.18932956523,1.13055109214521874,CDC-2010-Preterm distribut ion,7,源于神经病理的历史沿革,1867 Virchow, Parrott:脑室周围的损伤常见于早产儿;,1932 Rydberg循环功能不全一缺血,1962 Banker Larroche-PVL,1970s-1980 s Gills PtL:髓鞘、神经元,1995 Takashima S血管发育与轴突损伤:,2001 Volpe JJ, Kinney HC, Back SA一 preOL;,a 2005 Volpe JJ: EP(Encephalopathy of prematurity,源于神经病理的历史沿革,8,早产儿常见脑损伤临床病理基础与分类,Brain injury in premature infants: a complex amalgam of,destructive and developmental disturbances,loch Vale,ancet2009:8:110-24.,早产儿常见脑损伤临床病理基础与分类,9,A History of Our Understanding of,Cerebral Vascular Development and Pathogenesis,of Perinatal Brain Damage Over the Past 30 Years,Sachio Takashima. MD.Masayuki Itoh, MD. and Akira Oka. MD+,Ultrasound,lym,Glial proliferation,MRI,Cavity formation,Semin pediatr neurol 2009: 16: 226-236,A History of Our Understanding,10,早产儿脑白质损伤基础与MRI评价课件,11,早产儿脑白质损伤基础与MRI评价课件,12,早产儿脑白质损伤基础与MRI评价课件,13,早产儿脑白质损伤基础与MRI评价课件,14,早产儿脑白质损伤基础与MRI评价课件,15,早产儿脑白质损伤基础与MRI评价课件,16,早产儿脑白质损伤基础与MRI评价课件,17,早产儿脑白质损伤基础与MRI评价课件,18,早产儿脑白质损伤基础与MRI评价课件,19,早产儿脑白质损伤基础与MRI评价课件,20,早产儿脑白质损伤基础与MRI评价课件,21,早产儿脑白质损伤基础与MRI评价课件,22,早产儿脑白质损伤基础与MRI评价课件,23,早产儿脑白质损伤基础与MRI评价课件,24,早产儿脑白质损伤基础与MRI评价课件,25,早产儿脑白质损伤基础与MRI评价课件,26,早产儿脑白质损伤基础与MRI评价课件,27,早产儿脑白质损伤基础与MRI评价课件,28,早产儿脑白质损伤基础与MRI评价课件,29,早产儿脑白质损伤基础与MRI评价课件,30,早产儿脑白质损伤基础与MRI评价课件,31,早产儿脑白质损伤基础与MRI评价课件,32,早产儿脑白质损伤基础与MRI评价课件,33,早产儿脑白质损伤基础与MRI评价课件,34,早产儿脑白质损伤基础与MRI评价课件,35,早产儿脑白质损伤基础与MRI评价课件,36,早产儿脑白质损伤基础与MRI评价课件,37,早产儿脑白质损伤基础与MRI评价课件,38,早产儿脑白质损伤基础与MRI评价课件,39,早产儿脑白质损伤基础与MRI评价课件,40,早产儿脑白质损伤基础与MRI评价课件,41,早产儿脑白质损伤基础与MRI评价课件,42,早产儿脑白质损伤基础与MRI评价课件,43,早产儿脑白质损伤基础与MRI评价课件,44,早产儿脑白质损伤基础与MRI评价课件,45,早产儿脑白质损伤基础与MRI评价课件,46,早产儿脑白质损伤基础与MRI评价课件,47,早产儿脑白质损伤基础与MRI评价课件,48,早产儿脑白质损伤基础与MRI评价课件,49,早产儿脑白质损伤基础与MRI评价课件,50,早产儿脑白质损伤基础与MRI评价课件,51,早产儿脑白质损伤基础与MRI评价课件,52,早产儿脑白质损伤基础与MRI评价课件,53,早产儿脑白质损伤基础与MRI评价课件,54,早产儿脑白质损伤基础与MRI评价课件,55,早产儿脑白质损伤基础与MRI评价课件,56,早产儿脑白质损伤基础与MRI评价课件,57,早产儿脑白质损伤基础与MRI评价课件,58,早产儿脑白质损伤基础与MRI评价课件,59,早产儿脑白质损伤基础与MRI评价课件,60,早产儿脑白质损伤基础与MRI评价课件,61,早产儿脑白质损伤基础与MRI评价课件,62,早产儿脑白质损伤基础与MRI评价课件,63,早产儿脑白质损伤基础与MRI评价课件,64,早产儿脑白质损伤基础与MRI评价课件,65,早产儿脑白质损伤基础与MRI评价课件,66,早产儿脑白质损伤基础与MRI评价课件,67,早产儿脑白质损伤基础与MRI评价课件,68,早产儿脑白质损伤基础与MRI评价课件,69,早产儿脑白质损伤基础与MRI评价课件,70,早产儿脑白质损伤基础与MRI评价课件,71,早产儿脑白质损伤基础与MRI评价课件,72,早产儿脑白质损伤基础与MRI评价课件,73,早产儿脑白质损伤基础与MRI评价课件,74,早产儿脑白质损伤基础与MRI评价课件,75,早产儿脑白质损伤基础与MRI评价课件,76,早产儿脑白质损伤基础与MRI评价课件,77,早产儿脑白质损伤基础与MRI评价课件,78,