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单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,单击此处编辑母版标题样式,*,Company Logo,Sexually Transmitted Disease,Womens Hospital,School of Medicine Zhejiang University,Prof.Lin Jun,Sexually transmitted disease,STD,STD,is used to denote disorders spread principally by sexual intercourse or behavior similar to that.,Forms of transmission:,Sexual transmission,Indirect contact transmission,blood touch,iatrogenic(,医源性,),transmission,STD surveillance,in China,Syphilis,Gonorrhea,AIDS,Nongonococcal urethritis(NGU,非淋菌性尿道炎,),Condyloma acuminata(,尖锐湿疣,),Chancroid(,软下疳,),Lymphogranuloma venereum(,性病性淋巴肉芽肿,),Genital herpes(,生殖器疱疹,),Sexually transmitted disease,STD,Sexually transmitted disease,STD,Pathogens,：,Bacteria,Virus,Spirochete(,螺旋体,),Mycoplasma,Chlamydia,Protozoa(,原虫,),Fungi(,真菌,),Ectoparasite(,寄生虫,),Sexually transmitted disease,STD,Gonorrhea,Pathogen,：,Neisseria gonorrhoeae,Transmission,：,primarily by sexual contact,Invasion,：,columnar,epithelium,and transitional epithelium,cervix,urethra upper reproductive tract,Gonorrhea,Clinical findings,：,Incubation period,：,1-10 days,50%70%patients are asymptomatic.,1.Lower genital tract infection:,endocervicitis,urethritis,bartholinitis(,前庭大腺炎,),2.Upper genital tract infection:,pelvic inflammatory disease(PID),3.Disseminated gonococcal infection(DGI),pass by blood circulation,Gonorrhea,Diagnosis,：,According to bad sexual encounter,clinical findings and laboratory findings,Gram-negative diplococci(,双球菌,)can be seen microscopically in secretions.,Culture is the best standard.,PCR,Gonorrhea,Treatment,：,Principles,:promptly,、,full dose,、,antibiotics available,third generation cephalosporins,quinolones,Criterion of cure,：,Under the situation of no sexual life and 2 weeks after the whole therapy,the clinical symptoms and signs have gone.The 4-7d after cure,the smear testing and culture of secretion in cervical canals are negative.,Gonorrhea,Sexually transmitted disease,STD,Syphilis,Pathogen,：,Treponema pallidum,Transmission,：,sexually transmission,indirect contact transmission,blood touch,from infected mother to fetus,Syphilis,Clinical findings,：,1.Primary syphilis,：,chancre,(,硬下疳,),indurated,firm,painless papule or ulcer with raised borders,on labia,vulva,vagina,cervix,anus,lips,or nipples,2.Secondary syphilis,：,diffuse bilaterally symmetric extragenital papulosquamous eruption,(,丘疹鳞屑性皮疹,),condyloma latum,(,扁平湿疣,),3.Tertiary syphilis,：,cardiac,，,neurologic(,神经的,),ophthalmic(,眼的,),and auditory(,耳的,),lesions,Syphilis,secondary syphilis,condyloma latum,(,扁平湿疣,),secondary syphilis:,papulosquamous,(,丘疹疹鳞屑性皮疹,),Syphilis,Tertiary syphilis,Syphilis,Laboratory findings:,1.Identification of the organism,Darkfield microscopy examination,(,暗视野显微镜检查,),Treponema pallidum,(,梅毒螺旋体,),2.Serologic examination,a.Nontreponemal tests,(,非梅毒螺旋体抗原试验,),VDRL,RPR,syphilis screening(,筛查,),b.Treponemal tests,(,梅毒螺旋体抗原试验,),TPPA,TPHA,syphilis confirmation(,确诊,),3.Examination of cerebrospinal fluid,(,脑脊液,),Syphilis,Treatment,：,penicillin,Criterion of cure,：,Clinical cure,Serologic cure,Sexually transmitted disease,STD,Condyloma acuminata,（尖锐湿疣）,Pathogen:,human papilloma virus,(HPV),mainly Types 6 and 11 low-risk HPV,Transmission,：,sexually transmission,Condyloma acuminata,Clinical Findings,Symptoms,neoplasm,：,vulvae,cervix,vagina,perianal area,(,肛周,),vulvar pruritus,vulvar burning sensation,postcoital bleeding,Signs,：,Tiny,isolated or clustering pink papules,(,丘疹,),are present at first,then get together just like comb shape,(,鸡冠状,).,Condyloma acuminata,Condyloma acuminata,Laboratory Findings,Cytology,：,koilocytosis,(,挖空细胞,),dyskeratosis,(,角化不良细胞,),parakeratosis,(,角化不全细胞,),Acetic acid test,(,醋酸试验,),white,（,+,）,Colposcope,(,阴道镜,),Pathology,：,hyperplasia of squamous epithelium,PCR:HPV detect,Condyloma acuminata,Treatment,There is no cure for HPV although lesions can be removed.,External medicine,Podophyllin,(0.5%,足叶草脂毒素酊,鬼臼毒素,).,Trichloroacetic acid,(50%,三氯醋酸,),Physical therapy,Microwave,Laser therapy,Cryotherapy,Excision,Interferon,Thank You!,
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