系统性红斑狼疮患者妊娠管理课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,場州大荸学,SLE/APS患者妊娠的管理,张育,扬州大学医学院,苏北人民医院风湿免疫科,場州大荸学,育龄女,SLE流行病学特点:,性为主,患病率:,20-70/10万,性别:,男/女:1:9,年龄,20-39岁,Yamamete Y, et al. Int J womens Health. 2019:8:265-72,場州大荸学,SLE的预后明显改善:,1年存活率,9597%,5年存活率,872%,10年存活率,80.9%,10年存活率,65.2%,冫場州大荸,Decrease in Pregnancy loss rates in Patients with,ystemic Lupus Erythematosus Over a 40-Year Period,CHRISTINE A CLARK. KAREN A SPITZER and CARL A LASKIN,6666715708-3,对生育提出更高的要求! Clark Cetal. J Rheumata1mn,邕州太,TABLE 1: Hormonal aud immume response differences between marital pregnancies.,Immune and hormonal Response Normal pregnancy,lupus ad pigna,ThI,Estradiol and progeterone,Hisher in second and thind Lower in seond and thire,Impaired placental function and,Altered immune regulation,hiah in the third trimester,Low in lhe three lrirrrse,high in the last trims,oud iout pregl aucy and Coutinuous B cell stimul t ion,Treg cells,ow lurber aud impaired,Lupus activty,Chemokines,LOit,CXCLIO/P-10,Ficolin-3,Increase,I,Higher concentration,Prolactin,Higher concentratlon,Lupus activity,Fco|n3:纤维胶凝蛋白3; Prolactin:催乳素,de Jesus GR,et al. Autoimmune Dis, 2019: 2019: 943490. dol: 10. 1155/2019/943490,