呼吸系统疾病猪肺炎支原体课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,Respiratory Disease,Mycoplasma hyopneumoniae,吸系统疾病一芳航炎支原体,Bob morrison dvm,mba.phd,Swine Group,University of Minnesota,Mycoplasma hyopneumoniae,若肺炎支原体,Transmission is primarily by direct contact with carrier swine,传播的主要途径是与病原携带猪的直接接触。,Airborne transmission possible经呼吸道传播使感染成为可能,Any age pig is susceptible to infection,所有口龄的猪都易感,Maintained in herds by sow(primarily parity 1,2)to suckling,pig contact,在猪群中通过母猪(主要是第一、二产次母猪)与哺乳仔猪,接触导致其持续存在,Primary clinical problem is in growing pigs,3 to 6 months old,主要临床问题出现在3到6月龄的生长猪群身上,Mycoplasma hyopneumoniae,若肺炎支原体,Long incubation period-10to16 weeks长潜伏期-10-16周,Slow spread缓慢传播,Large numbers present in the early stages of disease,大量的病例出现于疾病的早期阶段,Disease onset is gradual-coughing for weeks to months,疾病的发病是渐进性的咳嗽可持续数周到数月,Disease course is markedly affected by concurrent or,secondary infections,疾病的进程明显受并发或继发感染的影响,High variation in virulence,病原毒力差异很大,What does m hyopneumoniae do?,猪肺炎支原体有什么影响?,Colonizes tracheal epithelium病原定居于气管上皮细胞,Destroys cilia in tracheobronchi,interferes with clearance,mechanisms,摧毁气管、支气管上皮的纤毛,干扰气管的清除机制,nterferes with macrophage activity干扰了巨噬细胞活性,Mononuclear peribronchial infiltration,单核细胞在支气管周围浸润,Produces lesions of pneumonia造成肺炎的病变,y be severe in susceptible animals对易感动物可能有严重后果,Produces slighADG导致猪平均口增重的轻微下降,Allows bacterial superinfections-Pasteurella,Strep,Actinobacillus,易发生细菌的双重感染巴氏杆菌、链球菌、放线菌,Immunohistochemical stain,免疫组化染色,tributed by Pal H,