青蒿素研发对中医效验方市场化的启示课件

,青蒿素研发对中医效验方,市场化的启示,Marketization Insight of Herbal Formula from Perspectives of Artemisinin R&D,青蒿素研发对中医效验方,主要内容,青蒿素研发背景与历史,Background and History of Artemisinin,R&D,对中医效验方市场化的启示,Marketization Insight of Herbal Formula,主要内容青蒿素研发背景与历史,Parasite resistant to available treatments in much of the world:new approaches to therapy essential,Chloroquine resistance,Sulfadoxine-Pyrimethamine resistance,Mefloquine resistance,Distribution of Drug Resistant Falciparum Malaria,Parasite resistant to availabl,最早记载青蒿应用,最早记载青蒿应用,青蒿素研发对中医效验方市场化的启示课件,青蒿素研发大事记,Milestones of artemisinin R&D,1967,：“,523,”协作组成立,Founding of“523”working group,1973,：单体成分“黄花蒿素”：高效，低毒,Extract with high effect,low toxicity from artemisea annua both in rodent and human malaria,1977,：明确化学结构,Determination of chemical structure,1979,：青蒿素研究成功,Declaration of successful R&D,青蒿素研发大事记Milestones of artemis,青蒿素研发大事记,Milestones of artemisinin R&D,1981,：青蒿素衍生物新药注册，并取代其他抗疟药成为一线治疗药（中国）。,Registrations and as the first-line antimalarial in China,1991-2000,：越南、柬埔寨、缅甸一线抗疟药,;,其他适应症,First-line antimalarial in Vietnam,Cambodia and Myanma,Other indications,2000,：,WHO,：抗疟治疗,青蒿素复方,Antimalarial policy:artemisinin combinations,2003-,：青蒿素复方快速灭疟方案,FEMSE,青蒿素研发大事记Milestones of artemis,1991-1995,越南,-,同奈,-,春禄,临床研究与推广应用,Clinical,trials,and promoted applications,(1991-2000),1991-1995 临床研究与推广应用(1991-2000),临床,研究和推广应用,临床研究和推广应用,临床研究和推广应用,临床研究和推广应用,首届,国际青蒿素临床研究会议,临床,研究和推广应用,首届国际青蒿素临床研究会议临床研究和推广应用,临床,研究和推广应用,临床研究和推广应用,Roll Back Malaria,Technical Consultation concluded that,from now on,any country changing antimalarial drug policy should change to an artemisinin combination,世卫组织：任何国家制定新的抗疟政策时都应该改用青蒿素复方,Roll Back MalariaTechnical Con,青蒿素研发对中医效验方市场化的启示课件,Jing-Bo Jiang,Guo-Qiao Li,et al,Antimalarial activity of mefloquine and qianghaosu,The Lancet,August 7,1982,1.,青蒿素与甲氟喹的抗疟作用比较,Jing-Bo Jiang,Guo-Qiao Li,et,1.,青蒿素与甲氟喹的抗疟作用比较,1.青蒿素与甲氟喹的抗疟作用比较,Guoqiao Li,Xingbo Guo,Linchun Fu,Huaxiang Jian and Xinhua Wang;Clinical trials of artemisinin and,its derivatives in the treatment of malaria in China.Trans.R.Soc.Trop.Med.Hyg.,(1994)88,2.,青蒿素及其衍生物治疗疟疾的临床研究,Guoqiao Li,Xingbo Guo,Linchu,陈沛泉,王新华,简华香,符林春,李国桥等，双氢青蒿素对恶性疟原虫有性生殖期的影响，,中药新药与临床药理，,1999,年,11,月第,10,卷第,6,期,3.,青蒿素对恶性疟原虫有性生殖期的作用,陈沛泉,王新华,简华香,符林春,李国桥等，双氢青蒿,3.,青蒿素对恶性疟原虫有性生殖期的作用,3.青蒿素对恶性疟原虫有性生殖期的作用,4.,青蒿琥酯治疗脑型疟疾临床研究,研究对象：脑型疟疾,106,例,研究方法：青蒿琥酯静脉注射,研究结果,:,疗效：治愈,98,例（,92.5%,）；死亡,8,例（,7.5%,）,昏迷清醒时间：,3632,小时,原虫转阴时间：,5931,小时,平均退热时间：,5440,小时,无明显毒副作用,Linchun Fu,Xinhua Wang et al.,Artesunate intravenous injection in treatment of cerebral,malaria-Clinical study on 106 cases.Chinese Medical Journal,1995,(5),4.青蒿琥酯治疗脑型疟疾临床研究研究对象：脑型疟疾106例L,5.,全民服药（青蒿素复方）快速控疟研究,Song et al.Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine,，,Malaria Journal 2010,9:57,5.全民服药（青蒿素复方）快速控疟研究Song et al.,青蒿素研发对中医效验方市场化的启示课件,Rapid,effect,速效,High,effect,高效,Broad stage,specificity,作用于无性体各周期,Reduces gametocyte,C,arriage作用于有性体,artemisinin,O,O,O,O,H,H,O,H,10,Rapid effect速效artemisininOOOOH,市场化启示,Marketization Insight of Herbal Formula,循证医学研究与学术推广,EBM R&D and marketing by academic promotion,古籍（民间）记载,研发,推广应用,Records in classic,R&D,promoted use,研发目标与路径（中药、天然药物注册分类）,R&D objective and strategy,辨证与辨病,Target:Syndrome or disease,市场化启示Marketization Insight of,灵丹草颗粒防治季节性流感的临床研究,灵丹草颗粒防治季节性流感的临床研究,瞄准,重大需求,Aiming at the great demands,国际化,视野,Internationalization view,知识产权,保护,Intellectual property protection,政产学研商,协同,Combined efforts among government,enterprise,universities,research institute and finance,市场化启示,Marketization Insight of Herbal Formula,瞄准重大需求市场化启示Marketization Insi,