抗癫痫药专业知识讲座

,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,抗癫痫药,Antiepileptic Drugs,北京协和医学院基础医学院药理学系,叶菜英,Definitions in epilepsy:,Epilepsy comprises recurrent episodes of abnormal cerebral neuronal discharge.The resulting seizures are usually clinically obvious and vary in pattern according to which parts of the brain are affected.,Epilepsy can be caused by many neurological diseases,including infection,trauma,infarction and neoplasia.,Heredity has an important role(especially in the idiopathic generalised epilepsies).,Normal brain cell,Abnormal high-frequency discharge,Focus,Drug action,Inhibit discharge,Stabilize membrane,inhibit the diffusion of discharge(primary),Common seizure types of Epilepsy:,Generalised seizures.,Absence(petit mal).,Tonic/clonic(grand mal).,Partial seizures.,Simple partial seizures.,Complex partial seizures(temporal lobe epilepsy).,Generalised seizures:,Absence(petit mal):,These seizures have abrupt onset and cessation,with impaired consciousness,but with normal posture often retained.The EEG shows a typical spike and wave pattern.,Tonic/clonic(grand mal):,Consciousness is impaired and the patient usually falls to the floor.A phase of muscle contraction(tonic)is followed by irregular muscle clonus and then by sleep.Injury may occur.,Partial seizures:,Simple partial seizures:,features depend on the part of the brain affected,result from discharge in the precentral gyrus.Consciousness is unimpaired.,Complex partial seizures(temporal lobe epilepsy):,Consciousness is impaired with complex,often repetitive,action.,The EEG in,seizure of Epilepsy,3 Hz Paradoxical discharge,Spike wave,Epilepsy,Pathogenesis:,The neuron in brain lesion depolarizes together suddenly,and then product high-frequency,out-break discharge.The discharge can diffuse to surrounding normal tissue extensive excitation the brain function transient aberration.,Normal brain cell,Abnormal high-frequency discharge,Focus,Drug action,Inhibit discharge,Stabilize membrane,inhibit the diffusion of discharge(primary),Epilepsy,Therapeutic principle:,Change the permeability of Na,+,Ca,2+,and K,+,in nerve cell membrane,degrade excitement stage,extend refractory phase.,Directly or indirectly increase CNS levels of GABA.,The primary,animal models,used in anti-,epileptic,drugs research,Maximal electroshock seizure(MES),model：,screen the drugs which used in,grand mal.,Pentetrazole(PTZ)induced,convulsion model:,screen the drugs which used in,petit mal.,Kindling seizure model:,screen the drugs which used in,grand mal.,S,pontaneously epileptic rat(SER)model,：,used in anti-,epileptic,drugs research.,memo:,将震颤大鼠与Zitter基因变异大鼠交配，于1986年哺育出SER鼠。它也具有震颤，脑海绵状变性等特点。是tm基因与Zitter（zi）基因共同突变旳成果。除了具有TRM大鼠旳重度失神发作之外，SER鼠还体现为高频率旳强直性自发痉挛。在SER鼠旳大脑皮质及海马用慢性统计电极作自发旳脑电波检验发觉，当SER失神发作时，出现与TRM鼠一样旳57Hz旳多波峰波群放电；在其出现强直性痉挛时，出现两个部位一致旳低振幅迅速波。中枢神经系统病理检验成果显示，SER除具有TRM鼠旳重度脑海绵状变性外，还出现了神经细胞低形成或形成异常，生殖器萎缩，不育，胡须和体毛屈曲，视觉障碍，听觉障碍，高级运动障碍等。,Classification of Antiepileptic Drugs,Hydantoins,：,Sodium,Phenytoin,Barbiturates：,Phenobarbital,Primidone,Succinimide：,Ethosuximide,Benzodiazepine:,Diazepam,Nitrazepam,Others:,Sodium Valproate,Sodium Phenytoin(苯妥英钠),【,Physiological disposition,】,Sodium Phenytoin is absorbed slowly after oral administration.After 6-10 days,its plasma concentration can achieve effect levels.This drug has variable interpatient plasma concentration.,Sodium Phenytoin,Mechanism of action:,It can block sodium channels(voltage-,frequency-,and time dependent fashion)and inhibit the generation of action potentials.,It can increase the function of inhibitory transmitter GABA,inhibit nerve terminal to uptake GABA and induce the increasing of GABA receptor,thereby enhance GABA-mediated postsynaptic inhibition.,Sodium Phenytoin,【Pharmacologic properties and clinical application】,Anti-epileptic：,It can be used for partial seizures and tonic/clonic seizures,but not for other generalised seizure types.,Peripheral neuralgia：,cranial nerve,ischiadic nerve and cranial nerve.,Arrhythmia:,membrane-stabilizing action.,Sodium Phenytoin,Digestive system,Gingival hyperplasia,Nervous system,Hematological system,Skeletal system,Allergic response,Others,【Adverse effects】,Sodium Phenytoin,【Adverse effects】,Digestive system:,anorexia,nausea,vomiting and abdominal pain(recommend to take it after meal).It may cause phlebitis after IV.,Gingival hyperplasia:,It common occurs in children and teenagers after long term use,the incidence rate is about 20%.Generally,this effect can resolve after drug withdraw 3 to 6 months.,Sodium Phenytoin,【Adverse effects】,Nervous system:,nystagmus,diplopia,vertigo,ataxia(usually only at very high concentration).Severe patient occurs language disorder,mental confusion and cataphora.,Hematological system:,Because it can inhibit the absorption of folinic acid and accelerate its metabolism.This drug also can inhibit folic acid reductase.So it may cause megaloblastic anemia after long-term use(recommend to pretreat with folinic acid).,Sodium Phenytoin,【Adverse effects】,Skeletal system: