空腹血糖变化对糖尿病发生的作用：一项前瞻性队列研究的结果课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,空腹血糖变化对糖尿病发生的作用：,一项前瞻性队列研究的结果,SCI,文章解析实例,2,Change in fasting plasma glucose and incident type 2 diabetes mellitus:results from a prospective cohort study.,空腹血糖变化对糖尿病发生的作用：SCI文章解析实例2Chan,Objective,（目的）,:,To investigate the association between changes in fasting plasma glucose(FPG)values and incident type 2 diabetes(T2D)in a cohort of the Iranian population.,（在一个伊朗人群队列中，探讨空腹血浆葡萄糖（,FPG,）值的改变与,2,型糖尿病（,T2D,）发病之间的关系。）,Design,（设计）,:,Prospective cohort study.,（前瞻性队列研究）,Setting,(,研究场所,):,This study was conducted within the framework of the Tehran Lipid and Glucose Study(TLGS)to investigate the association between change in FPG between baseline examination(19992001)and the second visit(20022005)with incident T2D.(,这项研究是在德黑兰脂质和葡萄糖调查研究（,TLGS,）的框架内进行的，主要研究：基线检查（,1999-2001,）与第二次检查（,2002-2005,年）期间的,FPG,变化值与,2,型糖尿病（,T2D,）发病之间的关系。,),Objective（目的）:,Participants(,参与者,),A total of 3981 non-diabetic participants aged 20years.(,共有,3981,例年龄,20,岁的非糖尿病参与者,),Outcome measure(,结果测量,),T2D was defined if the participant was using antidiabetic drugs or if FPG was 7mmol/L or if the 2h post-challenge plasma glucose(2-hPCG)was 11.1mmol/L.(,如果参与者使用抗糖尿病药物或,FPG7mmol/L,，或者,2,小时后血浆葡萄糖（,2-hPCG,）,11.1mmol/L,，则定义,T2D,。,),Participants(参与者),Results,During a median follow-up of 6.17years,after the second examination,288 new cases of T2D were identified.In a multivariate Cox proportional hazard analysis using age as timescale,we presented a simple model including FPG change(HR 1.19,95%CI 1.07 to 1.33)and baseline waist circumference(WC)(HR 1.004,95%CI 1.001 to 1.008)with a discriminative power(C-index)of 72%.Furthermore,we showed that the highest quartile of FPG change enhanced the T2D risk to 1.65(95%CI 1.2 to 2.27)compared with the lowest quartile(p for trend=0.004).The independent risk of FPG change resisted further adjustment with 2-hPCG change.Adding the 2-hPCG change only slightly increased the discriminative power of the model including FPG change and baseline value of WC(0.73%vs 0.72%).After the study population had been limited to those with normal fasting glucose/normal glucose tolerance,FPG change remained an independent predictor(HR 1.57,95%CI 1.31 to 1.88).,结果,所有参与者中位随访时间为,6.17,年，第二次检查以后进行随访，确定了,288,例新发,T2D,病例。在使用年龄作为时间尺度的多变量,Cox,比例风险分析中，我们提出了一个简单的模型，包括,FPG,变化（,HR 1.19,95,CI 1.07,至,1.33,）和基线腰围（,WC,）（,HR 1.004,95,CI 1.001,至,1.008,），达到了,72,的模型的辨别力（,C,指数）。此外，我们的研究显示，,FPG,变化的最高四分位数与最低四分位数相比，将,T2D,风险提高到,1.65,（,95,CI 1.2,至,2.27,），（,p,趋势,=0.004,）。在回归模型中加入了,2-hPCG,变化这个变量后，,FPG,变化的独立风险作用仍然存在。添加,2-hPCG,变化这个变量仅略微增加了包括,FPG,变化和,WC,基线值（,0.73 VS.0.72,）的模型的辨别力。将研究人群限于正常空腹血糖,/,葡萄糖耐量正常者，,FPG,变化仍然是独立预测因子（,HR 1.57,95,CI 1.31-1.88,）。,Results结果,Conclusions(,结论,),Two measurements of FPG obtained about 3years apart can help to identify populations at risk of incident T2D independently of important traditional risk factors and their changes,including 2-hPCG change.(,大约,3,年间两次测量的,FPG,有助于识别,T2D,发生风险的人群，并且独立于重要的传统危险因素及其变化，包括,2-hPCG,变化。,),Conclusions(结论),空腹血糖变化对糖尿病发生的作用：一项前瞻性队列研究的结果课件,前言,前言,材料和方法,材料和方法,材料和方法,材料和方法,材料和方法,材料和方法,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,结果,讨论,讨论,讨论,讨论,