catosal科特壮-犬猫疾病支持治疗药物

Klicken Sie, um das Titelformat zu bearbeiten,Klicken Sie, um die Formate des Vorlagentextes zu bearbeiten,Zweite Ebene,Dritte Ebene,Vierte Ebene,Fnfte Ebene,*,科特壮,犬猫疾病支持治疗药物,刘久占,13911572386,德国拜耳,The Power of Pink,支持治疗,支持治疗是指与特异性疗法配合的附加治疗,它可以缩短犬猫疾病的康复时间！,支持治疗,支持治疗是指与特异性疗法配合的附加治疗,它可以缩短犬猫疾病的康复时间！,支持治疗对犬猫的重要性,一般来说，疾病会降低犬猫新陈代谢机能，而新陈代谢机能降低又会延缓犬猫的康复。临床上特异性治疗不会恢复患病犬猫的新陈代谢机能。所以促进新陈代谢的支持治疗性药物会明显促进患病宠物的康复。,患病犬猫需要额外的能量来帮助疾病康复,总结,简而言之,:,患病动物需要更多的能量,:,正常的身体功能需要,从疾病中快速康复,支持治疗形式,平衡营养,充足休息,注意管理,增加多种维生素和矿物质,保护肝脏等,ATP+H,2,OADP+HPO,4,ENERGY,脂类和糖类最终利用的形式,(ATP),ATP,变成,ADP,并释放细胞利用的能量,(,如,:,提供给肌肉细胞,),能量的利用方式,能量,重要的因素,整个新陈代谢过程关键因素是磷元素的代谢,磷元素在,AMP-ADP-ATP,循环后,有部分会流失掉,理论上,磷元素加入到,ADP,分子中是提供能量储备的最好方式,能量,理想的支持治疗,磷会流失,需要不断补充,提供含能量储备的磷能帮助细胞更好的工作,!,随着能量需求的增加,富含能量的磷混合物可以满足新陈代谢的需求,CATOSAL,就是答案,每,ml,含量,:,布他磷,100.00 mg,Vit B,12,0.05 mg,Methyl,paraben,1.00 mg,Phosphorus,content,: 17.3 mg/ml,提供磷元素,提供维生素,其他,作用成分,磷含量,: 17.3 mg/ml,Catosal,疾病支持治疗的关键,科特壮的成分,布他磷,有机磷酸,无味的白色晶体,VB12,Butaphosphane,Vitamin B12,+,The Power of Pink,科特壮的成分,布他磷,无味的白色晶体,作用机理,通过促进,ADP-ATP,循环，促进机体能量 代谢。,促进机体的合成代谢过程。,激活犬猫机体非特异性免疫反应,恢复疲劳肌肉功能。,缓解应激,/,降低激素水平,De Groot J., van Der Werf J., van Reenen C., Schuurman T., Schmidt B. (2003) :,The effect of butafosfan (component of Catosal) on psychosocial stress in pigs.,J. Vet. Pharmacol. Therap. 26 (Suppl. 1), 222-223.,Van der Staay J., De Groot J., Schmidt B., Schuurman T. (2006) :,Effects of Catosal on the physiological and behavioral response to social stress in piglets.,Proceedings of the 19th IPVS Congress, Copenhagen, Denmark, Volume 2.,Simon F (1990) :,Study on stress reducing effect of butafosfan in sheep.,Institut fr Pharmakologie und Toxikologie, Veterinrmedizinische Universitt, Budapest, Hungary.,Bayer ID 12765.,Hnsel A., Fuhrmann H., Sallmann H.-P, Klee W. (1992) :,Infusion von Propionate and Butyrat als Belastungstest zur berprfung mglicher Butafosfanwirkungen auf den Energiestoffwechsel des Rindes.,Berl. Mnch. Tierrztl. Wschr. 105, 361-366.,Hasi Su-,rong, DU Xiao-,yan, ZHU,Bei,-lei, JIANG Jin-,shu,(2004a):,Studies on Effects of Compound Butaphosphan Solution on Endurance Capability and Energy,Metabolism in Mice.,Acta Veterinaria Et Zootechnica Sinica, 35 (03 ), 290-294.,降低冷热刺激,Stress Reduction / control of cortisol increase,.,Hasi Su-,rong,et al. (2004a),*:p0.05, *p:0.001 compared to control group,*: p0.05 compared to high dose butaphosphan,*,*,*,%,High dose butaphosphan (n=15) : 250 mg/kg butaphosphan once a,day for 7 days orally.,Low dose butaphosphan (n=15) 125 mg/kg butaphosphan once a,day for 7 days orally.,Control group (n=15): 10 ml/kg physiologic saline once a day,for 7 days oral.,One hour after treatment on the last day, each mouse was placed,In a 300 ml wide-mouthed flask which was sealed with a double layer of,gauze. In order to evaluate the cold tolerance, this was placed in a,metabolic cage at 5,0.5 C with a cyclic pump. But, for the evaluation of,heat tolerance the temperature was 4,50.5 C.,In the cold tolerance study, after 10 hours the number of mice still alive,was recorded. In the heat tolerance study, after 50 minutes, the number,of mice still alive was recorded,.,布他磷作用于组织缺氧,Hasi Su-rong et al. (2004a),*p:0.05, *p:0.001 compared to control group,*,*,存活时间,(,分钟,),High dose butaphosphan (n=12) : 250 mg/kg butaphosphan once a,day for 7 days orally.,Low dose butaphosphan (n=12) 125 mg/kg butaphosphan once a,day for 7 days orally.,Control group (n=12): 10 ml/kg physiologic saline once a day,for 7 days oral.,One hour after treatment on the last day, each mouse was placed,In a 300 ml wide-mouthed flask which was sealed with transparent glad wrap,That did not admit air and timing was commenced. With the termination of,breathing as the endpoint, the time for each mouse to expire from lack of oxygen was noted, so as to determine the effect of butaphosphan,on the tolerance of mice hypoxia.,刺激能量产生,参考资料,:,Hasi Su-,rong, DU Xiao-,yan, ZHU,Bei,-lei, JIANG Jin-shu (2004a):,Studies on Effects of Compound Butaphosphan Solution on Endurance Capability and Energy,Metabolism in Mice.,Acta Veterinaria Et Zootechnica Sinica, 35 (03 ), 290-294.,HASI Su-rong , JIANG Jin-,shu, DU Xiao-,yan, ZHU,Bei,-lei (2005a):,Anti-cold stress effects and mechanisms of compound butaphosphan solution.,Progress in Veterinary Medicine, 26, (03), 59-62.,HASI Su-rong , JIANG Jin-,shu, ZHU,Bei,-lei , DU Xiao-,yan,(2005b) :,Studies on Anti-Heat Stress Effects and Mechanisms of Compound Butafosfan Solution.,Acta Veterinaria Et Zootechnica Sinica, 36 (12), 1334-1338.,布他磷刺激肝糖元产生,Content of liver gycogen (mg/g),*,*,*,= p0.05, *,= p0.001,Compared to control group,Hasi Su-,rong,et al. (2004a),Experiment 1(n=12): 250 mg/kg,butaphosphan once a day,for 7 days orally.,Experiment 2 (n=12): 125 mg/kg,butaphosphan once a day,for 7 days orally.,Control group (n=12) : 10 ml/kg,physiologic saline solution.,One hour after last treatment on the,last day, mice were sacrificed and,liver glycogen content was determined,via spectrometer,布他磷刺激肌糖元产生,Content of muscle glycogen (mg/g),*,*,*,= p0.01, *,= p0.001,Compared to control group,Hasi Su-,rong,et al. (2004a),Experiment 1(n=12): 250 mg/kg,butaphosphan once a day,for 7 days orally.,Experiment 2 (n=12): 125 mg/kg,butaphosphan once a day,for 7 days orally.,Control group (n=12) : 10 ml/kg,physiologic saline solution.,One hour after last treatment on the,last day, mice were sacrificed and,muscle glycogen content was determined,via spectrometer,提高 肌肉中的,Tri-phosphate (ATP),含量,Content of muscle ATP (mg/g),*,*,= p0.001,Compared to control group,Hasi Su-,rong,et al. (2004a),Butaphosphan treatment group (n=12):,250 mg/kg butaphosphan once a day,for 7 days orally.,Control group (n=12) : 10 ml/kg,physiologic saline solution.,One hour after last treatment on the,last day, mice were sacrificed and,muscle ATP content was determined,via HPLC.,提高肝脏功能,Studies,Frll M., Witteck Th., Gengenbach S., Schmidt B. (2006) :,Effects of pre-operative application of butaphosphan and cyanocobalamine on reconvalescence clinico-chemical parameters, antioxidavive metabolism and postoperative abomosal emptying in cows with abomosal dislocation.,Tierrztl. Prax. 34 (G): 351-356.,HASI Su-rong , JIANG Jin-,shu, DU Xiao-,yan, ZHU,Bei,-lei (2005a):,Anti-cold stress effects and mechanisms of compound butaphosphan solution.,Progress in Veterinary Medicine, 26, (03), 59-62.,HASI Su-rong , JIANG Jin-,shu, ZHU,Bei,-lei , DU Xiao-,yan,(2005b) :,Studies on Anti-heat Stress Effects and Mechanisms of Compound Butafosfan Solution.,Acta Veterinaria Et Zootechnica Sinica, 36 (12), 1334-1338.,Sommer H., Marx D., und Starker G. (1971) :,Studies to reduce reproductive disorders in cattle by using Catosal as metaphylaxis.,Dtsch. Tierrtzl.Wschr. 78, 593 616.,Flasshoff F.-H. (1974) :,Clinical and chemical blood serum investigations in cattle and treatment studies with ornithine-aspartate-product HMV 20 and with Catosal for the reduction of fertility and health disorders.,Doctorate Thesis, Tierrztliche Hochschule Hannover, Germany.,Marbach W (1980) :,Alkalische Phosphatase (AP) und Aspartataminotransferase (AST) des Blutplasmas als Parameter der Kondition von Rennpferden und die Wirkung von Coforta/Catosal auf diese Enzyme.,Vet. Med. Nahchr., 12.,CATOSAL:,营养肝脏,ASAT (U/l),50,100,150,200,250,300,350,Catosal,对照组,谷草转氨酶,(ASAT),是一种线粒体内的酶，当肝脏或肌肉损伤或肝脏代谢负担过重是会释放到血液中。,科特壮能促进糖异生的过程，这样减轻肝脏的负担。,0d,1d,2d,3d,post OP,科特壮,-,药理作用,游离脂肪酸,(mol/l),200,600,1000,1400,1800,2200,0d,1d,2d,3d,CATOSAL:,营养肝脏,血液中的游离脂肪酸含量是脂肪代谢的指标，脂肪代谢不好时其含量高,用科特壮治疗后游离脂肪酸含量比未治疗明显降低,Catosal,对照组,Catosal,药理作用,科特壮的成分,VB12,水溶性,提供钴元素,需要不断摄入,作用方式,调节蛋白质、脂类和碳水化合物的新陈代谢,提供钴元素，帮助红细胞合成。,促进蛋氨酸合成，而蛋氨酸是机体蛋白质重要的合成原料。,促进身体生长,提高食物利用率。,黑色晶体,吸水性,科特壮,-,药理作用,CATOSAL:,抗氧化作用,布他磷是一种,-,氨基磷酸,可以保护犬猫机体免受氧化损伤。,CATOSAL:,促进生长发育,布他磷能够影响宠物的中间代谢（,GIESECKE 1985,），主要表现为促进能量代谢、提高蛋白质合成（,KAEMMERER 1984, KIETZMANN 1986,）和促进生长发育。,实验证明，给予科特壮、维生素以及硒元素可使动物生长速度提高,38%,（,El-,Sherif,et al., 1981,） 。,促进生长发育得益于科特壮能促进新陈代谢和提高肌肉的运动,科特壮,-,药理作用,CATOSAL:,激活非特异性免疫,科特壮可以阻止因热应激而出现的抗体依赖性细胞毒作用,动物试验和细胞学试验均表明,科特壮是一种重要的非特异免疫增强剂,CATOSAL:,营养肝脏,当血清谷草转氨酶,(AST),升高后，应用科特壮可以降低,AST,的含量。,应激状态下，科特壮可以稳定,AST,正常水平,Catosal,非常安全,布他磷的急性毒性试验特别低,(LD50,鼠,/ i.v,鸡,i.m.,最高为,. 10,000 mg / kg BW),LD50,口服,79.4 ml,Catosal,/ Kg B.W.,LD50,皮下,100.0 ml,Catosal,/ Kg B.W.,LD50,静脉,48.0 ml,Catosal,/ Kg B.W.,无致突变,致癌和致畸（三致）作用,对免疫系统没有副作用,布他磷无毒,Catosal,用法用量,适应症,促进疾病恢复,增强食欲,感染性疾病辅助治疗,:,细小病毒感染,冠状病毒感染,犬传染性肝炎,原虫感染,脓皮症,促进肌肉损伤恢复,Catosal,用法用量,其他适应症,配合肠道寄生虫治疗,缓解应激：变换环境，展示等,身体虚弱,贫血,非生理性脱毛,工作犬、繁殖犬的营养补充剂,用法用量,犬,猫,疾病恢复,1,5ml/,天,0.5,2.5ml/,天,增加食欲,1,5ml/,天,0.5,2.5ml/,天,非生理性脱毛,4-8,天内间隔使用,3,次,每次,0.5,5ml,用法用量,皮下、肌肉和静脉注射均可，鸽子可以口服,Catosal,注射剂,