肺癌英文ppt课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,Lung cancer,9/16/2024,Definition,Background,Malignant,neoplasm,arising from,bronchial epithelium,9/16/2024,Historical note,100,years ago,200,cases reported,1895,Roentgen,diagnosis,possible,1904,Sauerbruch,negative-pressure cabin,1912,Davies first lung,lobectomy,1941,Zhang,Jizheng,pneumonectomy,9/16/2024,Epidemiology,Morbidity,19th century,rare,disease,Before 1950s,be,rising,Recent,50 years increased,sharply,leading,cause of cancer death,9/16/2024,Etiology,Occupational exposure,Lung cancer,Air pollution,Lung infection,Genetic factors,Smoking,9/16/2024,Dominant,Tumor suppressor,K-,ras,p53,Myc,family,3p,c-jun,rb,Growth factor,Protein tyrosine,phosphatase,-,TGF-,nm23,EGFR,C-erbB2,Oncogenes,and Tumor suppressor genes,Return,9/16/2024,Pathology,Lung carcinogenesis,Anatomic location,Histological classification,Invasion and Metastasis,TNM staging,9/16/2024,Lung carcinogenesis,columnar epithelium,squamous,metaplasia,carcinoma in situ,metastatic,carcinoma,infiltrating carcinoma,Injury,Risk factors,Return,9/16/2024,Anatomic location,Right,Central,Peripheral,Left,Upper,Middle,lower,Upper,lower,Return,9/16/2024,Classification,Percentage,NSC,75%,Adenocarcinoma,35%,Squamous cell carcinoma,30%,Large Cell carcinoma,10%,SCC,20%,Carcinoids,4%,Rare,1%,Histological classification of lung cancer,Return,9/16/2024,Return,9/16/2024,Return,9/16/2024,Return,9/16/2024,Invasion and Metastasis,Local infiltrate,Bronchial lumen,Direct extension,9/16/2024,Lymphatic,metastasis,Pulmonary,hilum,nodes,Cervical nodes,Mediastinum,nodes,Intrapulmonary nodes,9/16/2024,Distant metastasis,Lung cancer,Bone,Brain,Other,Liver,Pv,Return,9/16/2024,TNM staging,T-Primary Tumor,N-Lymph node,M-Metastasis,9/16/2024,Primary Tumor,9/16/2024,Primary Tumor,9/16/2024,Lymph node,9/16/2024,Metastasis,M,0,no,distant metastasis,M,1,distant metastasis,9/16/2024,T,1,T,2,T,3,T,4,N,0,a,b,b,b,N,1,a,b,a,b,N,2,a,a,a,b,N,3,b,b,b,b,Return,TNM staging,9/16/2024,Clinical presentation,E,arly stage,Advanced stage,Paraneoplastic,Syndromes,9/16/2024,E,arly stage,No symptom,Cough,Pneumonic symptoms,Hemoptysis,Dyspnea,Wheezing and,Stridor,9/16/2024,Advanced,stage,Mediastinal,invasion,Pleural effusions,Pancoasts tumor,Metastatic,symptoms,Phrenic,nerve invasion Hoarse voice Superior vena cava syndrome pericardial effusions,Dysphagia,9/16/2024,Paraneoplastic,Syndromes,Cushings syndrome,SIADH,Hypercalcemia,Gynecomastia,Clubbing and,Hypertrophic,pulmonary osteoarthropathy,Peripheral neuropathy,9/16/2024,Diagnosis,History and Physical examination,Noninvasive laboratory testing,Invasive examinations,9/16/2024,Noninvasive laboratory testing,Sputum Cytology,Chest Radiograph,Computed Tomography,Magnetic Resonance Imaging,Radionuclide Scanning,Bone scans,PET,9/16/2024,Invasive examinations,Transthoracic,needle aspiration,Bronchoscopy,Cervical,mediastinoscopy,Lymphatic nodes biopsy,Thoracoscopy,Thoracotomy,9/16/2024,Differential Diagnosis,Pulmonary Tuberculosis,Pulmonary,Infection,B,enign Lung Tumors,Mediastinal,Lyphoma,9/16/2024,Pulmonary Tuberculosis,Tuberculoma,Lung cancer,9/16/2024,Miliary,Tuberculosis,Bronchioloalveolar,carcinoma,9/16/2024,Pulmonary,Infection,Lung cancer,Pulmonary abscess,9/16/2024,Pneumonia,Obstructive,atelectasis,9/16/2024,B,enign Lung Tumors,Hamartoma,Bronchial Tumor,9/16/2024,Mediastinal,Lymphoma,9/16/2024,Treatment,Surgical intervention,Radiotherapy,Chemotherapy,others,Chenese,medicine,Immunotherapy,9/16/2024,Surgical intervention,Pulmonary resection,Lymph nodes dissection,Systemic lymph nodes dissection,Slective,lymph nodes dissection,9/16/2024,*Wedge resection,*Segmental resection,*,Lobectomy,*,Pneumonectomy,*,Sleeve,lobectomy,*VATS,*Extended,r,esection,Return,9/16/2024,Radiotherapy,Palliative radiotherapy,Postoperative radiotherapy,Tumor,unresectable,Lymphatic metastasis Incomplete resection,9/16/2024,Chemotherapy,Introduction chemotherapy,MVP,NP TP EP GP,Adjuvant chemotherapy,9/16/2024,9/16/2024,