资源描述
单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,乳腺癌放疗靶区勾画,乳腺癌放疗靶区勾画,1,保乳术后放疗N+,1214 women with BCS and node- posit,n BCS+,Time ( years,Time(years),保乳术后放疗N+,2,乳腺癌放疗靶区勾画参考幻灯片课件,3,EBCTCG: 2019,Figure 1. Effect of radiothe rapy(RT) aft,(BCS)on 10-year risk,nee and,isks of breast cancer,all- cause mortality among 10,801 women(67% pathological ly node ne gative) in 17 trials.,Vertical Ines indicate 1 SE abowe or below the 5, 10 and 15 year percentages. Further details are in webappendix pa,10ygan15:7%(810)%,15 y gaIn38%(811)%,15-y gain 3.0%(sE 1.2),RR052(5%c10484056)60,R082(95%,086-099,Logrank2p00000,Logrank 2p = 0-00005,Logrank 2p =003,50,40,4 BCS+R,15 years,5 10 15 years,15 years,Lancet20l.378:17074,EBCTCG: 2019,4,根治术后放疗 LANCET,2019,Effect of radiotherapy after mastectomy and axillary surgery,on 10-year recurrence and 20-year breast cancer mortality,meta-analysis of individual patient data for 8135 women in,22 randomised trials,EBCTCG(Early Breast Cancer Trialists Collaborative Group),772 PN4+women with Mast+AD,og-lank 2p0-00001,10-year gain 88s(.,nk本-00003,og-rank 2p-0-44,根治术后放疗 LANCET,2019,5,314 PN1-3 women with Mast+ AD,O-yedr yl 1170E3,:o64094,E,5,33.8,314 PN1-3 women with Mast+ AD,6,NCCN MVA,PMRT HR=0.12P=0.006,INBC HR=14,P=0.001,P=0.012,30.03,LVSI,me after mastectomy (months),7412741,H院2w/如ums24524447,2,Tseng et al, Int Radiation Oncol Biol Phys, VoL 93, No 3, pp. 622e630, 2019(NCCN outcomes,NCCN MVA,7,21基因评分对于 NSABP B-14andB-20,LN阴性患者局部区域复发的价值,e 50 Yoas,RS High ( n=49,e 50 Years RS Irt. (na 31),4 Positive Nodes,N=386),N=218),Intermediate 132,Pvalue=0.64,P-value =0.006,in Years,Time in Yea,Mamo as et at ssoa,Mamounas E Pet al. J Clin Oncol30, 2019(suppl 27: abstr 11,21基因评分对于 NSABP B28,9,18基因评分,a Cell cycle and proliferation:(DDX39, BUBIB, STIL,TPX2, CCNB1),a Sustained proliferation: Oncogenic process(BL,TCF3, PIMI, RCHY1, PTI1,a Tumor-promoting inflammation and avoiding immune,destruction,RI. NFATC2IP,o Cell-cell interaction and EMT:(TRPV6, OBSLI,MMP15,o Resistance to apoptosis(C16ORF7, DTX2(Notch),Altered metabolism: (ENSA),18基因评分,10,乳腺癌放疗靶区勾画参考幻灯片课件,11,乳腺癌放疗靶区勾画参考幻灯片课件,12,乳腺癌放疗靶区勾画参考幻灯片课件,13,乳腺癌放疗靶区勾画参考幻灯片课件,14,乳腺癌放疗靶区勾画参考幻灯片课件,15,乳腺癌放疗靶区勾画参考幻灯片课件,16,乳腺癌放疗靶区勾画参考幻灯片课件,17,乳腺癌放疗靶区勾画参考幻灯片课件,18,乳腺癌放疗靶区勾画参考幻灯片课件,19,乳腺癌放疗靶区勾画参考幻灯片课件,20,乳腺癌放疗靶区勾画参考幻灯片课件,21,乳腺癌放疗靶区勾画参考幻灯片课件,22,乳腺癌放疗靶区勾画参考幻灯片课件,23,乳腺癌放疗靶区勾画参考幻灯片课件,24,乳腺癌放疗靶区勾画参考幻灯片课件,25,乳腺癌放疗靶区勾画参考幻灯片课件,26,乳腺癌放疗靶区勾画参考幻灯片课件,27,乳腺癌放疗靶区勾画参考幻灯片课件,28,乳腺癌放疗靶区勾画参考幻灯片课件,29,乳腺癌放疗靶区勾画参考幻灯片课件,30,乳腺癌放疗靶区勾画参考幻灯片课件,31,乳腺癌放疗靶区勾画参考幻灯片课件,32,乳腺癌放疗靶区勾画参考幻灯片课件,33,乳腺癌放疗靶区勾画参考幻灯片课件,34,乳腺癌放疗靶区勾画参考幻灯片课件,35,乳腺癌放疗靶区勾画参考幻灯片课件,36,乳腺癌放疗靶区勾画参考幻灯片课件,37,乳腺癌放疗靶区勾画参考幻灯片课件,38,乳腺癌放疗靶区勾画参考幻灯片课件,39,乳腺癌放疗靶区勾画参考幻灯片课件,40,乳腺癌放疗靶区勾画参考幻灯片课件,41,乳腺癌放疗靶区勾画参考幻灯片课件,42,乳腺癌放疗靶区勾画参考幻灯片课件,43,乳腺癌放疗靶区勾画参考幻灯片课件,44,乳腺癌放疗靶区勾画参考幻灯片课件,45,乳腺癌放疗靶区勾画参考幻灯片课件,46,乳腺癌放疗靶区勾画参考幻灯片课件,47,乳腺癌放疗靶区勾画参考幻灯片课件,48,乳腺癌放疗靶区勾画参考幻灯片课件,49,
展开阅读全文