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单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,房颤消融术中的左房房扑,Left Atrial Flutter During Stepwise Linear Ablation of AF,中国医学科学院 阜外心血管病医院 心律失常中心,Arrhythmia Center，Fuwai Herat Hospital,Chinese Academy of Medical Sciences,姚 焰 Yan Yao,背景 Background,与房颤消融相关的左房房扑LAFL发生率介于2.631%1；,The morbidity of AF ablation related left atrial flutter(LAFL)are 2.631%;,包括局灶、大折返或小折返等多种机制且多与房颤消融线的“缝隙有关；,Focal、micro-,1,Gerstenfeld EP,Heart Rhythm 2007;4:S65-72,个体化递进式线性消融术,Stepwise Linear Ablation Approach,病例数 Patients(n),80,性别 Gender:男性(M)/女性(F),60/20,年龄 Age(岁，years),579,房颤持续时间 Duration of AF(年,years),74,阵发性 Paroxysmal/持续性房颤 Persistent AF,62/18,左房内径 LA diameter(mm),388,左室射血分数 LVEF(%),526,器质性心脏病 Structral Heart Disease,16(20%),既往抗心律失常药物 AADs（n),21,LAFL患者根本特点 Basic Characteristics of LAFL Patients,结果 Results,LAFL可在消融中由AF转化而成，或房颤消融成功之后快速刺激诱发；,LAFLs were either converted from AF by ablation or induced by CIS；,34例有2(26)种的LAFL，共有146种，其中4种为局灶性，142种为大折返机制；,There were 34 pts.with 2(26)LAFLs，of total 146 LAFLs，142 were reentrant&4 were focal；,142种LAFL均与房颤消融线的缝隙有关，且均位于7字消融线上；,The reentrant circuits were all related with the gaps on the Figure“7 lesions line.,Case 1：绕MVA的折返 Reentrant around the MVA,消融嵴部时AF转为LA AFL,V1,CS7.8,5,6,7,8,9,10,11,12,13,14,15,16,180ms,Lead I,ISOCHRONES,绕二尖瓣环的折返(Isochronal map of the MVA circuit),1.等时图显示为绕MVA的顺钟向折返；,2.沿MVA冲动时间占心动过速周长的100；,3.折返环路上全程虚拟单极电图呈rS型且首尾相接；,经MVALIPV峡部的“缝隙The gap on MVA-LIPV isthmus,在峡部缝隙处消融转为窦律,Termination of the LAFL,Case2：7字型消融终止房颤后CS S1S1 320bpm诱发LAFL,LAFL induced after termination of AF with figure“7 lesions,Case2：经LAA-LSPV间嵴部缝隙的折返 Reentrant through the gap at LAA-LSPV ridge,左房房扑的动态等电位图,等时图 Isochronal map,在嵴部消融终止了LAFLLAFL terminated during ablation at the LAA-LSPV ridge,Case 3:经左房顶部缝隙折返的LAFL Reentrant though the gap on the LA roof,左房房扑的动态等电位图,等时图 Isochronal Map,在顶部缝隙处消融终止了LAFLLAFL termination during ablation on the gap,与左房房扑折返环相关的缝隙分布The distribution of the LAFL related gaps,LAA-LSPV 嵴部,（LAA-LSPV rigde）,68(47%),二尖瓣环峡部（MVA isthmus）,24 (17%),左房顶部,（LA roof）,50(36%),7字消融线的多个缝隙Multiple Gaps on the Figure“7 lesion line,顶部的缝隙 Gap on LA Roof,嵴部的缝隙 Gap at LAA-LSPV Ridge,MVA的缝隙 Gap at LIPV-MVA Isthmus,最终消融成功部位 Final Target,消融效果 Ablation Results,能量,:功率60W，温度58，每次60-90s；,平均放电,4 2.1 次；,即时成功率(消融终止+不再诱发):,LSPV-LAA间嵴部：60/68(88.2%)；,左房顶部：44/50(88%)；,LIPV-MVA峡部：22/24(92%)；,随访 Follow up,平均(11 6.7)月：,维持窦律(sinus rhythm):62/80(77.5%)；,短阵房速(focal AT):12/80(15%)；,左房房扑(LAFL):6/80(7.5)；,新发现 New Findings,缝隙的分布：,既往研究中经二尖瓣环峡部缝隙的折返多见，本研究中经LAALSPV间嵴部及左房顶部缝隙的折返更多见；,Gaps on LAA-LSPV ridge&roof were more common in this study；,折返环类型：,既往报告经嵴部的折返环多为小折返，本研究中为经嵴部及RIPV-MVA间峡部的大折返。,Most of the reentrant were macro circuits across ridge；,AF的机制 Mechanism of AF,快速的异位节律 focal;,单个折返环伴颤抖性传导,single randomized wave front with fibrillatory activation；,3)多个折返环?multiple wavelets？,姚焰 中华心律失常学杂志,2004;8;356,消融线上缝隙的成因,The formation of the gaps on the lesions line,LSPV-LAA间嵴部解剖特殊性1：,Anatomic features,局部肌带厚、狭窄；,肌纤维走行复杂；,邻近神经节及Marshall韧带；,LSPV-LAA间嵴部消融导管贴靠困难2,3；,顶部正中有毗邻组织结构和心包折叠；,现有消融能量的局限性；,1.Cabrera JA,Eur Heart J.2021;29:356-62.,2.Deisenhofer I,Europace 2006;8:573-82.,3.Mesas CE,JACC 2004;44:1071-9.,Cabrera JA,et al.Eur Heart J.2021;29:356-62.,D,并发症 或 消融成功的过渡阶段？,Complication or Transform to the Success of AF ablation？,步进式线性消融的可行性已得到证实1,2；,The feasibility of stepwise linear ablation approach were confirmed.,当前消融能量无法平安地形成透壁损伤；,Complete transmurality is not guaranteed with current ablation energy;,LAFL可能是当前阶段房颤消融难以防止的过渡阶段但有望在组织和电重构后消失；,LAFL may possibly be the transform during the successful ablation process of AF;,1,Yao Y,Heart Rhythm 2007,2,Bortone A,JCE 2021 19:338-341,总 结,Conclusions,步进式线性消融术中大折返机制的左房房扑多见且均与7字型消融线上尤其嵴部和顶部的缝隙有关；,Macro reentrant LAFLs are common and mostly related with gaps on figure“7 lesion line especially on LAA-LSPV ridge and LA roof；,非接触标测能够有效识别缝隙并指导消融；,Array provides an accurate&fast mapping technique for the targeting of the gaps；,
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