InhibitionofMatrix-Metallo-proteinasesbyGarlicCompounds大蒜化合物的基质金属蛋白酶的抑制作用

Klicken Sie,um das Titelformat zu bearbeiten,Klicken Sie,um die Formate des Vorlagentextes zu bearbeiten,Zweite Ebene,Dritte Ebene,Vierte Ebene,Fnfte Ebene,*,Inhibition of Matrix-Metallo-proteinases by Garlic Compounds,R.Gebhardt and K.Meyer,Institute of Biochemistry,University of Leipzig,MMP,MMP,MMP,TIMP,TIMP,TIMP,ArteriosklerosisFibrosis,ArthritisDiabetic,Rheumatoid Arthritis Nephropathy,InflammationGlomerulosklerosis,Tumour-GrowthSclerodemie,-Metastasis,-Angiogenesis,Ulcers,Parodontosis,Morphogenesis,Differentiation,Wound healing,etc.,Pathological Implicationsof MMP-TIMP-Imbalance:,Spectrum of matrix metalloproteinases,in cultured HUVEC cells.,After 9 h of cultivation,.,Spectrum of MMPs in HCAEC,cells,Inhibition of MMP-1 Production in Endothelial Cells by Diallyldisulfide,Inhibition of MMP-2 Production by DADS,AM and SAC,(HUVEC,9 h),Inhibition of MMP-9 Production by DADS and AM,(HUVEC stimulated with TNF-alpha,forscolin and PMA,24 h),Inhibition of MMP-2 Production by DADS,AM and SAC,(HCAEC,9 h),Conclusions:,DADS,is able,to,inhibit the production of several MMPs,particularly,in HCAEC,cells,AM,is less,potent,than,DADS,Garlic powder,(PRI-200,MOR-200),has,a,similar effect,Garlic powder,(PRI-0),is less effective,Garlic preparations might influence the,MMP-TIMP,balance,Questions:,What,is,the,effect,of,DADS,on the production of TIMPs,?,What is the effect of garlic powder on TIMPs,?,