THE MECHANNISMS FOR THE ANTIBACTERIAL ACTIVITY OF ANTIBIOTICS

Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,THE MECHANNISMS FOR THE ANTIBACTERIAL ACTIVITY OF ANTIBIOTICS,胡秋靈,3 major mechanisms,1st:affect the synthesis of cell wall,2nd:affect the function of cell membrane,3rd:inhibit the biosynthesis of protein,the 1st mechanism,the structure of cell wall,the 1st mechanism,the 1st mechanism,作用机制,抗生素,主要作用靶位,抑制细菌细胞壁肽聚糖生物合成,-内酰胺类磷霉素,糖肽类,环丝氨酸,杆菌肽,抑制转肽酶活性，破坏肽聚糖相互交联；,与肽聚糖生物合成中的UDP-,N,-乙酰葡糖胺丙酮酰转移酶结合，阻断UDP-,N,-乙酰葡糖胺向UDP-,N,-乙酰胞壁酸的转化；,与D-丙氨酰-D-丙氨酸结合，抑制转糖基和转肽反应；,抑制丙氨酸消旋酶和D-丙氨酰-D-丙氨酸合成酶；,抑制焦磷酸酶，阻断肽聚糖跨膜载体十一聚异戊二烯醇再生。,the 2nd mechanism,the 2nd mechanism,作用机制,抗生素,主要作用靶位,破坏微生物细胞质膜功能,多烯类,唑类抗真菌药物,托萘酯(发癣退),多粘菌素B,粘杆菌素,短杆菌肽S,脂肽类,(Daptomycin),与组成真菌细胞膜的麦角固醇结合，破坏膜的功能；,抑制真菌羊毛固醇脱甲基酶(细胞色素P-450)，阻断麦角固醇合成；,抑制真菌角鲨烯单加氧酶；,类似阳离子洗涤剂的作用，破坏细菌细胞膜的磷脂结构；,切断细菌电子传递系统与氧化磷酸化的偶联；,与G,+,细菌的脂磷壁酸结合，使细胞质膜去极化，从而破坏膜的传输功能,。,the 3rd mechanism,the 3rd mechanism,作用机制,抗生素,主要作用靶位,抑制蛋白质生物合成,氨基糖苷类,四环素类,氯霉素、林肯霉素和大环内酯类,春日霉素,卷曲霉素,噁唑烷二酮类,与核糖体30S亚基和50S亚基结合，抑制肽酰-tRNA转位,与30S亚基结合，抑制氨基脂酰基-tRNA与mRNA密码子依赖性核糖体A位结合,作用于50S亚基中的23S核蛋白体RNA(rRNA)，抑制肽酰基转移酶,抑制30S亚基与甲酰蛋氨酸-tRNA复合物的形成,与30S及50S亚基结合，抑制蛋白质合成的开始阶段和延长过程的转位,与50S亚基的23S rRNA结合，干扰70S功能起始复合物的形成,Q:Why antibiotics donot directly affect he viability of eukaryotic cells?,A:1.Most eukanyotic cells donot have cell wall,and,most antibiotics have the 1st mechanism;,2.Antibiotics are applied to bacteria rathan than animal,cells or plant cells etc,and bacteria are prokaryotes,not eukatyotes.,谢谢,观赏,以上訊息均為網路尋找而得，,若有偏差不妥之處，請多指教。,