资源描述
单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,文档仅供参考，不能作为科学依据，请勿模仿；如有不当之处，请联系网站或本人删除。,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,文档仅供参考，不能作为科学依据，请勿模仿；如有不当之处，请联系网站或本人删除。,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,文档仅供参考，不能作为科学依据，请勿模仿；如有不当之处，请联系网站或本人删除。,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,文档仅供参考，不能作为科学依据，请勿模仿；如有不当之处，请联系网站或本人删除。,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,文档仅供参考，不能作为科学依据，请勿模仿；如有不当之处，请联系网站或本人删除。,ALLICS在儿童哮喘长期维持治疗中的应用培训课件,1,中华医学会儿科学分会呼吸学组,等,.,儿童支气管哮喘诊断与防治指南,.,中华儿科杂志,2008,46(10):745-753.,2,Rank MA,et al.,The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids:a systematic review and meta-analysis of randomized controlled trials.J Allergy Clin Immunol,2013,131(3):724-9.,3,Castro-Rodriguez GA,et al.The role of inhaled corticosteroids and montelukast in children with mildmoderate asthma:results of a systematic review with meta-analysis.Arch Dis Child,2010,95:365370.,4 Szefler SJ,et al.Budesonide inhalation suspension versus montelukast in children aged 2 to 4 years with mild persistent asthma.J Allergy Clin Immunol:In Practice,2013,1:58-64,。,5,McLaughlin T,et al.Risk of recurrent emergency department visits or hospitalizations in children with asthma receiving nebulized budesonide inhalation suspension compared with other asthma medications.Current Medical Research and Opinion,2007,23(6):13191328.,6,GINA.2012:40.,7,Brand PL.Inhaled corticosteroids should be the first line of treatment for children with asthma.Padiatric Respiratory Reviews,2011,12:245249.,8,申昆玲,等,.,糖皮质激素雾化吸入疗法在儿科应用的专家共识,.,临床儿科杂志,2011,29(1):86-91.,9,Kemp JP,et al.Once-daily budesonide inhalation suspension for the treatment of persistent asthma in infants and young children.,Ann Allergy Asthma Immunol,1999,83:231239.,10,Baker JW,et al.A Multiple-dosing,placebo-controlled study of budesonide inhalation suspension given once or twice daily for treatment of persistent asthma in young children and infants.Pediatrics,1999,103(2):414-421.,1 中华医学会儿科学分会呼吸学组,等.儿童支气管哮喘诊断,达到并维持症状的控制,维持正常活动，包括运动能力,使肺功能水平尽量接近正常,预防哮喘急性发作,避免因哮喘药物治疗导致的不良反应,预防哮喘导致的死亡,儿童哮喘的治疗目标,中华医学会儿科学分会呼吸学组,等,.,儿童支气管哮喘诊断与防治指南,.,中华儿科杂志,2008,46(10):745-753.,达到并维持症状的控制儿童哮喘的治疗目标中华医学会儿科学分会呼,长期、持续、规范、个体化治疗,快速缓解症状,防止症状加重和预防复发,哮喘的防治原则,中华医学会儿科学分会呼吸学组,等,.,儿童支气管哮喘诊断与防治指南,.,中华儿科杂志,2008,46(10):745-753.,总原则,急性发作期,慢性持续期和临床缓解期,长期、持续、规范、个体化治疗哮喘的防治原则中华医学会儿科学分,1,中华医学会儿科学分会呼吸学组,等,.,儿童支气管哮喘诊断与防治指南,.,中华儿科杂志,2008,46(10):745-753.,2,Rank MA,et al.,The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids:a systematic review and meta-analysis of randomized controlled trials.J Allergy Clin Immunol,2013,131(3):724-9.,3,Castro-Rodriguez GA,et al.The role of inhaled corticosteroids and montelukast in children with mildmoderate asthma:results of a systematic review with meta-analysis.Arch Dis Child,2010,95:365370.,4 Szefler SJ,et al.Budesonide inhalation suspension versus montelukast in children aged 2 to 4 years with mild persistent asthma.J Allergy Clin Immunol:In Practice,2013,1:58-64,。,5,McLaughlin T,et al.Risk of recurrent emergency department visits or hospitalizations in children with asthma receiving nebulized budesonide inhalation suspension compared with other asthma medications.Current Medical Research and Opinion,2007,23(6):13191328.,6,GINA.2012:40.,7,Brand PL.Inhaled corticosteroids should be the first line of treatment for children with asthma.Padiatric Respiratory Reviews,2011,12:245249.,8,申昆玲,等,.,糖皮质激素雾化吸入疗法在儿科应用的专家共识,.,临床儿科杂志,2011,29(1):86-91.,9,Kemp JP,et al.Once-daily budesonide inhalation suspension for the treatment of persistent asthma in infants and young children.,Ann Allergy Asthma Immunol,1999,83:231239.,10,Baker JW,et al.A Multiple-dosing,placebo-controlled study of budesonide inhalation suspension given once or twice daily for treatment of persistent asthma in young children and infants.Pediatrics,1999,103(2):414-421.,1 中华医学会儿科学分会呼吸学组,等.儿童支气管哮喘诊断,长期规律雾化吸入,ICS,治疗的必要性,一项系统综述纳入,7,项比较停用和继续使用,ICS,对哮喘急性发作风险的研究，荟萃分析结果表明，对于哮喘控制良好的哮喘患者来说，与继续使用,ICS,患者相比，停用,ICS,可使哮喘急性发作风险增加,停药哮喘加重,Rank MA,et al.,The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids:a systematic review and meta-analysis of randomized controlled trials.J Allergy Clin Immunol.2013;131(3):724-9.,哮喘加重相对风险值增加,2.35,倍,肺功能指标：,FEV,1,降低,130mL,晨间,PEF,降低,18L/min,平均标准哮喘症状评分增加,0.43,倍,长期规律雾化吸入ICS治疗的必要性一项系统综述纳入7项比较停,1,中华医学会儿科学分会呼吸学组,等,.,儿童支气管哮喘诊断与防治指南,.,中华儿科杂志,2008,46(10):745-753.,2,Rank MA,et al.,The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids:a systematic review and meta-analysis of randomized controlled trials.J Allergy Clin Immunol,2013,131(3):724-9.,3,Castro-Rodriguez GA,et al.The role of inhaled corticosteroids and montelukast in children with mildmoderate asthma:results of a systematic review with meta-analysis.Arch Dis Child,2010,95:365370.,4 Szefler SJ,et al.Budesonide inhalation suspension versus montelukast in children aged 2 to 4 years with mild persistent asthma.J Allergy Clin Immunol:In Practice,2013,1:58-64,。,5,McL
展开阅读全文