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单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,外泌体在肿瘤研究中的应用,外泌体在肿瘤研究中的应用,1,癌细胞作为受体,癌种细胞种类外泌体内含物效应,Breast cancer Macrophages,Proliferation,pancreatic,miRNA,colon,stromal ce,ncRNA,migration;,astri,Fibroblasts,circRNA,nvasion,Dendritic Ce,Angiogenesis;,ppe,bladd,Differentiation,癌细胞作为受体,2,外泌体在肿瘤中的研究课件,3,癌细胞作为供体,癌种,癌细胞状态,内含物效应细胞,Norma,蛋白,Proliferation,cancer,mirNa epithelial cells,pancreatic hypoxia,IncRNA Endothelial Cell,Invasion,Resistance,circrNa NK Cell,Angiogenesis,gastric Triple-negative breast DNA MDSCs,Premetastatic Niche,ng,cancer,Liver cells,appoptosis,Differentiation,bladder Cancer stem cells,tumor-associated,Resistance,Gene expression cells,macrophage,EMT.,Vin,T cells,MET,Drug treated,fibroblasts,Impair Lymphocyte,bone marrow,progenitor,癌细胞作为供体,4,例,1. Cancer EXosomes Perform Cell-Independent MicroRNA,Biogenesis and Promote Tumorigenesis,2. Exosomes Secreted under Hypoxia Enhance Invasiveness,and Stemness of Prostate Cancer Cells by targeting Adherens,Junction molecules,3. Cancer Exosomes Trigger Fibroblast to Myofibroblast,Differentiation,4. Exosome derived from epigallocatechin gallate treated breast,cancer cells suppresses tumor growth by inhibiting tumor-,associated macrophage infiltration and M2 polarization,5. Human tumor virus utilizes exosomes for intercellular,communication,6. Murine Mammary Carcinoma EXosomes Promote Tumor,Growth by Suppression of NK Cell Function,例,5,应用: The novel biomarkers,内含物,Blood,蛋白,early pancreatic cancer,Urinal,ry,miRNA,Sunitinib resistance,Salivary,long noncoding RNA Castration-resistant,DNA,Prognostic Markers,DNA methylation,exosome,ww.exOsomedx/patients,应用: The novel biomarkers,6,例,1. Clinical Impact of serum Exosomal MicroRNA-21 As a clinical,Biomarker in Human Esophageal Squamous Cell Carcinoma,2. Glypican-1 identifies cancer exosomes and detects early,pancreatic cancer,3. Double-stranded dna in exosomes a novel biomarker in,cancer detection,4. Exosomal long noncoding rna crnde-h as a novel serum-,based biomarker for diagnosis and prognosis of colorectal,cancer,例,7,应用: Therapy,外泌体特点内含物受体,应用,2 containingL2,CTL, macrophages, In vivo/in vitro,tumor cel,NK cells,exosomes,and b lymphocytes,GEl1-or EGF- SiRNA,EGFR-expressing In vivo/in vitro,positIve,cancer tissues,exosomes,SMNC-EXOs Doxorubicin H22 cells,In vivo/in vitro,IFN-Y-Dex,MHC,NK cells,phase ll clinical,应用: Therapy,8,例,1. Exosomes derived from IL-12-anchored renal cancer cells,increase induction of specific antitumor response in vitro,2. Systemically Injected EXosomes Targeted to EGFR Deliver,Antitumor Microrna to breast Cancer Cells,3. A phase I study of exosome immunotherapy in patients with, advanced non-smal!cel lung cancer;,4. Dendritic cell-derived exosomes as maintenance immunotherapy,after first line chemotherapy in Nsclc,例,9,路:,1测序(蛋白 mRNa/mirna/ncrna/circRNA),2.测序(蛋白 mRNA/ miRNA/ncRNA/circRNA+临床验证,3功能+测序(蛋白 mRNA miRNA/ ncRNa/circRNA),4功能+简单信号通路,5功能+蛋白/ mRNA miRNA/ ncRna circRNA+下游机制,6功能+蛋白/ mrna mirnA/ ncRNA/ circRNA+上游调控,7功能+蛋白 mrnamirnaincrna/circRNA+上游调控+下游机,8创新性想法提出,路:,10,外泌体在肿瘤中的研究课件,11,外泌体在肿瘤中的研究课件,12,外泌体在肿瘤中的研究课件,13,外泌体在肿瘤中的研究课件,14,外泌体在肿瘤中的研究课件,15,外泌体在肿瘤中的研究课件,16,外泌体在肿瘤中的研究课件,17,外泌体在肿瘤中的研究课件,18,外泌体在肿瘤中的研究课件,19,外泌体在肿瘤中的研究课件,20,外泌体在肿瘤中的研究课件,21,外泌体在肿瘤中的研究课件,22,外泌体在肿瘤中的研究课件,23,外泌体在肿瘤中的研究课件,24,外泌体在肿瘤中的研究课件,25,
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