软骨和骨组织学和胚胎学课件

,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,#,1. Cartilage:,organ=Cartilage tissue+perichondrium,1. Cartilage:,1,1),structure of cartilage tissue,-cell: chondrocyte,-cartilage matrix,1) structure of cartilage,2,chondrocyte:,-Structure: LM,embedded in cartilage,lacuna,peripheral cells:,-small and immature,-single and flattened,central cell:,-large and mature,-round and in group of 2-8 cells,-small and round nucleus,-basophilic cytoplasm,-EM: rich in RER and Golgi complex, chondrocyte:,3,*,isogenous group,: several cells locates in one lacuna, which are derived from a single(same) parent cell,*isogenous group: several cell,4,Cartilage matrix,-ground substance:,proteoglycan:,-same to loose CT,-there are more chondroitin sulfate distributed at the periphery of cartilage lacuna-called as cartilage capsule(basophilic),water,-fiber: type and number of fiber depends on the type of cartilage,5,2) Classification: according to the fiber,Hyaline cartilage:,less collagenous fibril,articular surface, rib cartilage, trachea and bronchi,2) Classification: according t,6,Fibrous cartilage:,large amount of collagenous fiber bundles,cells are small and less,intervertebral disc, symphysis pubis,Fibrous cartilage:,7,-function: provide nutrition and osteoblast for bone growth and repairing,circumferential lamella:,-small and immature,Hydroxyapatite crystal:,Cartilage:,-structure:,-small and immature,*bone lamella: bone matrix arranged in layers at different direction,RER, mito.,-organic matter:,-single and flattened,RER, mito.,-there are more chondroitin sulfate distributed at the periphery of cartilage lacuna-called as cartilage capsule(basophilic),primary lysosome, pinosome and secondary lysosome,ground substance:,cuboidal or low columnar cell,light zone: -under the ruffled border,-round and in group of 2-8 cells,Self study!,-inorganic matter: bone salts,Elastic cartilage:,large amount of elastic fiber,external ear, epiglottis,-function: provide nutrition,8,3) perichondrium,two layers:,-out layer: contain more fiber-protection,-inner layer: more cells-osteoprogenitor cell(fusiform in shape),软骨和骨组织学和胚胎学课件,9,4) growth of cartilage,-interstitial growth:,inner chondrocyte proliferation produce fiber and matrix.,immature cartilage,-appositional growth:,osteoprogenitor cellchondroblast chondrocyte produce fiber and matrix.,growing and mature cartilage,4) growth of cartilage,10,2.Bone,-consists of bone tissue, periosteum and endosteum, bone marrow,2.Bone,11,release matrix vesicle:,exist in periosteum and endosteum,form a spongy-liked network,-appositional growth:,-structure:,-there are more chondroitin sulfate distributed at the periphery of cartilage lacuna-called as cartilage capsule(basophilic),light zone: -under the ruffled border,longitudinal arranged,/irregular lamella,less collagenous fibril,/irregular lamella,longitudinal arranged,-basophilic cytoplasm,Cartilage:,primary lysosome, pinosome and secondary lysosome,organ=Cartilage tissue+perichondrium,1) Bone tissue,Bone matrix,/central canal: N, BV, CT,Self study!,1),Bone tissue, Cells:,release matrix vesicle:1),12,a.,osteoprogenitor cell,: stem cell,-structure:,fusiform, small,ovoid nucleus,slight basophilic cytoplasm,exist in periosteum and endosteum,-function: differentiated into osteoblast and chondrocyte,a. osteoprogenitor cell: stem,13,b. osteoblast,:,-structure:,LM:,single layer of,cuboidal or low columnar cell,round nucleus,basophilic cytoplasm,located on the surface of bone tissue,软骨和骨组织学和胚胎学课件,14,EM:,fine processes,rich in RER, Golgi complex,EM:,15,-function:,.synthesize bone collagen fiber and ground,substance-osteoid,.release matrix vesicle:,0.1um in diameter,membrane-coated,function: promote calcification,-function:,16,c.osteocyte,-structure:,flattened cell with multiple,long thin processes,located in bone lacuna,and bone canaliculus,basophilic cytoplasm,adjacent cells connect in bone,canaliculus by gap junctions,-function:,Maintain bone matrix,c.osteocyte,17,软骨和骨组织学和胚胎学课件,18,d. osteoclast,-structure: LM:,multinuclear large cell, 30-100um,6-50 nuclei,acidophilic cytoplasm,located at peripheral part of bone,d. osteoclast,19,EM:,ruffled border-processes,light zone: -under the ruffled border,-microfilament,primary lysosome, pinosome and secondary lysosome,RER, mito. and Golgi,-function: dissolve and absorb bone matrix,软骨和骨组织学和胚胎学课件,20,Bone matrix,-organic matter:,bone collagen fiber -collagenous fiber (type I collagen),ground substance:,glycosaminoglycan,Bone matrix,21,-inorganic matter: bone salts,Hydroxyapatite crystal:,Ca,10,(PO,4,),6,(OH),2,pin-shaped,longitudinal arranged,*bone lamella: bone matrix arranged in layers at different direction,-inorganic matter: bone salt,22,-inner layer: more cells-osteoprogenitor cell(fusiform in shape),-small and round nucleus,primary lysosome, pinosome and secondary lysosome,exist in periosteum and endosteum,1um in diameter, Cartilage matrix,inner layer:,articular surface, rib cartilage, trachea and bronchi,organ=Cartilage tissue+perichondrium,-large and mature,form a spongy-liked network,Bone matrix,-small and immature,consists of compact bone,-Structure: LM,4) growth of cartilage,-small and immature,/remnant of Haversian,/central canal: N, BV, CT,embedded in cartilage,2) Architacture of long bone,Long bone is an organ, made up of bone tissue(shaft and epiphyses), periosteum and endosteum, bone marrow,-inner layer: more cells-ost,23, shaft:,consists of compact bone,a.,circumferential lamella:,/outer concentrically-arranged,/inner around inner surface of bone, shaft:,24,b.,Haversian system (osteon):,/cylindric structure, 3-5mm,/central canal: N, BV, CT,/Haversian lamella: 4-20 layers,软骨和骨组织学和胚胎学课件,25,c.,i,nterstitial lamella:,/irregular lamella,/remnant of Haversian,or circumferential lamella,*perforating canal:,/transverse canal,/connect with Haversian canal,软骨和骨组织学和胚胎学课件,26,epiphyses,: composed of spongy bone,-trabeculae:,formed by parallelly-arranged lamella,form a spongy-liked network,-Bone marrow: hemopoietic tissue, epiphyses: composed of spong,27, periosteum and endosteum: CT membrane,-periosteum: DCT,outer layer:more fiber bundles,form perforating fiber,inner layer:,rich in BV, N and osteoprogenitor cells,-endosteum: thin, a layer of osteoprogenitor cell and CT,-function: provide nutrition and osteoblast for bone growth and repairing, periosteum and endosteum: CT,28,3),osteogenesis,Self study!,3)osteogenesis,29,1. Cartilage:,organ=Cartilage tissue+perichondrium,1. Cartilage:,30,3) perichondrium,two layers:,-out layer: contain more fiber-protection,-inner layer: more cells-osteoprogenitor cell(fusiform in shape),软骨和骨组织学和胚胎学课件,31,4) growth of cartilage,-interstitial growth:,inner chondrocyte proliferation produce fiber and matrix.,immature cartilage,-appositional growth:,osteoprogenitor cellchondroblast chondrocyte produce fiber and matrix.,growing and mature cartilage,4) growth of cartilage,32,1),Bone tissue, Cells:,1) Bone tissue,33,软骨和骨组织学和胚胎学课件,34,formed by parallelly-arranged lamella,circumferential lamella:,inner layer:,Hydroxyapatite crystal:,acidophilic cytoplasm,-function:,-appositional growth:,/central canal: N, BV, CT,-small and immature,-out layer: contain more fiber-protection,light zone: -under the ruffled border,circumferential lamella:,interstitial lamella:,1) Bone tissue,-small and immature,/Haversian lamella: 4-20 layers,RER, mito.,-small and round nucleus,less collagenous fibril,light zone: -under the ruffled border,-there are more chondroitin sulfate distributed at the periphery of cartilage lacuna-called as cartilage capsule(basophilic),/irregular lamella,/irregular lamella,-function: dissolve and absorb bone matrix,-there are more chondroitin sulfate distributed at the periphery of cartilage lacuna-called as cartilage capsule(basophilic),exist in periosteum and endosteum,/cylindric structure, 3-5mm,-function: differentiated into osteoblast and chondrocyte,embedded in cartilage,consists of compact bone,Ca10(PO4)6(OH)2,Self study!,multinuclear large cell, 30-100um,two layers:,-function:,form a spongy-liked network,-small and round nucleus,basophilic cytoplasm,Hydroxyapatite crystal:,-small and round nucleus,Self study!,basophilic cytoplasm, epiphyses: composed of spongy bone,1um in diameter,acidophilic cytoplasm,2) Architacture of long bone,-inner layer: more cells-osteoprogenitor cell(fusiform in shape),osteoprogenitor cellchondroblast chondrocyte produce fiber and matrix.,osteoprogenitor cell: stem cell,-out layer: contain more fiber-protection,*bone lamella: bone matrix arranged in layers at different direction,-cell: chondrocyte,-function: provide nutrition and osteoblast for bone growth and repairing,less collagenous fibril,light zone: -under the ruffled border,Self study!,osteoprogenitor cell: stem cell,basophilic cytoplasm,-appositional growth:,-there are more chondroitin sulfate distributed at the periphery of cartilage lacuna-called as cartilage capsule(basophilic),-small and immature,/remnant of Haversian,4) growth of cartilage,/irregular lamella,located at peripheral part of bone,located in bone lacuna,basophilic cytoplasm,-structure:,-structure:,*isogenous group: several cells locates in one lacuna, which are derived from a single(same) parent cell,less collagenous fibril,Self study!,-there are more chondroitin sulfate distributed at the periphery of cartilage lacuna-called as cartilage capsule(basophilic),less collagenous fibril,-EM: rich in RER and Golgi complex,Self study!,basophilic cytoplasm,Long bone is an organ, made up of bone tissue(shaft and epiphyses), periosteum and endosteum, bone marrow,-basophilic cytoplasm,-same to loose CT,1um in diameter,form a spongy-liked network,acidophilic cytoplasm,/central canal: N, BV, CT,-function:,less collagenous fibril,basophilic cytoplasm,6-50 nuclei,/irregular lamella,-fiber: type and number of fiber depends on the type of cartilage,-basophilic cytoplasm,Bone matrix,4) growth of cartilage,inner chondrocyte proliferation produce fiber and matrix.,pin-shaped,cuboidal or low columnar cell,-small and immature,-organic matter:,light zone: -under the ruffled border,articular surface, rib cartilage, trachea and bronchi,multinuclear large cell, 30-100um,/connect with Haversian canal,2) Architacture of long bone,growing and mature cartilage,-structure:,-structure:,formed by parallelly-arranged lamella,/irregular lamella,-organic matter:, Cartilage matrix,basophilic cytoplasm,embedded in cartilage,-cartilage matrix,/cylindric structure, 3-5mm, Cells:,form perforating fiber,growing and mature cartilage,-Structure: LM,-single and flattened,Self study!,organ=Cartilage tissue+perichondrium, epiphyses: composed of spongy bone,less collagenous fibril, shaft:,consists of compact bone,a.,circumferential lamella:,/outer concentrically-arranged,/inner around inner surface of bone,formed by parallelly-arranged,35,