软骨和骨组织学和胚胎学完美版课件

,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,#,1.Cartilage:,organ=Cartilage tissue+perichondrium,1.Cartilage:,1,1),structure of cartilage tissue,-cell:chondrocyte,-cartilage matrix,1)structure of cartilage,2,chondrocyte:,-Structure:LM,embedded in cartilage,lacuna,peripheral cells:,-small and immature,-single and flattened,central cell:,-large and mature,-round and in group of 2-8 cells,-small and round nucleus,-basophilic cytoplasm,-EM:rich in RER and Golgi complex,chondrocyte:,3,*,isogenous group,:several cells locates in one lacuna,which are derived from a single(same)parent cell,*isogenous group:several cell,4,Cartilage matrix,-ground substance:,proteoglycan:,-same to loose CT,-there are more chondroitin sulfate distributed at the periphery of cartilage lacuna-called as cartilage capsule(basophilic),water,-fiber:type and number of fiber depends on the type of cartilage,5,2)Classification:according to the fiber,Hyaline cartilage:,less collagenous fibril,articular surface,rib cartilage,trachea and bronchi,2)Classification:according t,6,Fibrous cartilage:,large amount of collagenous fiber bundles,cells are small and less,intervertebral disc,symphysis pubis,Fibrous cartilage:,7,cells are small and less,peripheral cells:,or circumferential lamella,and bone canaliculus,-consists of bone tissue,periosteum and endosteum,bone marrow,Ca10(PO4)6(OH)2,-round and in group of 2-8 cells,round nucleus,/central canal:N,BV,CT,-small and immature,/cylindric structure,3-5mm,two layers:,release matrix vesicle:,substance-osteoid,chondrocyte:,proteoglycan:,-inner layer:more cells-osteoprogenitor cell(fusiform in shape),/outer concentrically-arranged,proteoglycan:,Elastic cartilage:,large amount of elastic fiber,external ear,epiglottis,cells are small and lessElasti,8,3)perichondrium,two layers:,-out layer:contain more fiber-protection,-inner layer:more cells-osteoprogenitor cell(fusiform in shape),软骨和骨组织学和胚胎学完美版课件,9,4)growth of cartilage,-interstitial growth:,inner chondrocyte proliferation produce fiber and matrix.,immature cartilage,-appositional growth:,osteoprogenitor cellchondroblast chondrocyte produce fiber and matrix.,growing and mature cartilage,4)growth of cartilage,10,longitudinal arranged,growing and mature cartilage,-microfilament,-appositional growth:,Ca10(PO4)6(OH)2,-microfilament,consists of compact bone,or circumferential lamella,external ear,epiglottis,Fibrous cartilage:,1)Bone tissue,long thin processes,4)growth of cartilage,-appositional growth:,inner layer:,organ=Cartilage tissue+perichondrium,*perforating canal:,immature cartilage,-small and immature,periosteum and endosteum:CT membrane,3)osteogenesis,cells are small and less,2.Bone,-consists of bone tissue,periosteum and endosteum,bone marrow,longitudinal arranged2.Bone,11,1),Bone tissue,Cells:,1)Bone tissue,12,a.,osteoprogenitor cell,:stem cell,-structure:,fusiform,small,ovoid nucleus,slight basophilic cytoplasm,exist in periosteum and endosteum,-function:differentiated into osteoblast and chondrocyte,a.osteoprogenitor cell:stem,13,b.osteoblast,:,-structure:,LM:,single layer of,cuboidal or low columnar cell,round nucleus,basophilic cytoplasm,located on the surface of bone tissue,软骨和骨组织学和胚胎学完美版课件,14,EM:,fine processes,rich in RER,Golgi complex,EM:,15,-function:,.synthesize bone collagen fiber and ground,substance-osteoid,.release matrix vesicle:,0.1um in diameter,membrane-coated,function:promote calcification,-function:,16,c.osteocyte,-structure:,flattened cell with multiple,long thin processes,located in bone lacuna,and bone canaliculus,basophilic cytoplasm,adjacent cells connect in bone,canaliculus by gap junctions,-function:,Maintain bone matrix,c.osteocyte,17,软骨和骨组织学和胚胎学完美版课件,18,d.osteoclast,-structure:LM:,multinuclear large cell,30-100um,6-50 nuclei,acidophilic cytoplasm,located at peripheral part of bone,d.osteoclast,19,EM:,ruffled border-processes,light zone:-under the ruffled border,-microfilament,primary lysosome,pinosome and secondary lysosome,RER,mito.and Golgi,-function:dissolve and absorb bone matrix,软骨和骨组织学和胚胎学完美版课件,20,Bone matrix,-organic matter:,bone collagen fiber-collagenous fiber(type I collagen),ground substance:,glycosaminoglycan,Bone matrix,21,glycosaminoglycan,-trabeculae:,-microfilament,light zone:-under the ruffled border,*perforating canal:,periosteum and endosteum:CT membrane,and bone canaliculus,membrane-coated,-fiber:type and number of fiber depends on the type of cartilage,function:promote calcification,multinuclear large cell,30-100um,Ca10(PO4)6(OH)2,circumferential lamella:,round nucleus,light zone:-under the ruffled border,*bone lamella:bone matrix arranged in layers at different direction,4)growth of cartilage,interstitial lamella:,/central canal:N,BV,CT,cells are small and less,/central canal:N,BV,CT,Cells:,-inorganic matter:bone salts,Hydroxyapatite crystal:,Ca,10,(PO,4,),6,(OH),2,pin-shaped,longitudinal arranged,*bone lamella:bone matrix arranged in layers at different direction,glycosaminoglycan-inorganic,22,2)Architacture of long bone,Long bone is an organ,made up of bone tissue(shaft and epiphyses),periosteum and endosteum,bone marrow,2)Architacture of long bone,23,shaft:,consists of compact bone,a.,circumferential lamella:,/outer concentrically-arranged,/inner around inner surface of bone,shaft:,24,b.,Haversian system(osteon):,/cylindric structure,3-5mm,/central canal:N,BV,CT,/Haversian lamella:4-20 layers,软骨和骨组织学和胚胎学完美版课件,25,c.,i,nterstitial lamella:,/irregular lamella,/remnant of Haversian,or circumferential lamella,*perforating canal:,/transverse canal,/connect with Haversian canal,软骨和骨组织学和胚胎学完美版课件,26,epiphyses,:composed of spongy bone,-trabeculae:,formed by parallelly-arranged lamella,form a spongy-liked network,-Bone marrow:hemopoietic tissue,epiphyses:composed of spong,27,periosteum and endosteum:CT membrane,-periosteum:DCT,outer layer:more fiber bundles,form perforating fiber,inner layer:,rich in BV,N and osteoprogenitor cells,-endosteum:thin,a layer of osteoprogenitor cell and CT,-function:provide nutrition and osteoblast for bone growth and repairing,periosteum and endosteum:CT,28,3),osteogenesis,Self study!,3)osteogenesis,29,1.Cartilage:,organ=Cartilage tissue+perichondrium,1.Cartilage:,30,3)perichondrium,two layers:,-out layer:contain more fiber-protection,-inner layer:more cells-osteoprogenitor cell(fusiform in shape),软骨和骨组织学和胚胎学完美版课件,31,4)growth of cartilage,-interstitial growth:,inner chondrocyte proliferation produce fiber and matrix.,immature cartilage,-appositional growth:,osteoprogenitor cellchondroblast chondrocyte produce fiber and matrix.,growing and mature cartilage,4)growth of cartilage,32,1),Bone tissue,Cells:,1)Bone tissue,33,inner layer:,flattened cell with multiple,-trabeculae:,Cartilage:,light zone:-under the ruffled border,-round and in group of 2-8 cells,basophilic cytoplasm,3)perichondrium,Cartilage:,-cell:chondrocyte,-periosteum:DCT,/outer concentrically-arranged,or circumferential lamella,light zone:-under the ruffled border,substance-osteoid,cells are small and less,*perforating canal:,epiphyses:composed of spongy bone,slight basophilic cytoplasm,-interstitial growth:,Maintain bone matrix,-small and immature,inner layer:,34,-interstitial growth:,proteoglycan:,/outer concentrically-arranged,round nucleus,chondrocyte:,osteoclast,Fibrous cartilage:,membrane-coated,/remnant of Haversian,Fibrous cartilage:,Cartilage:,/central canal:N,BV,CT,*perforating canal:,-periosteum:DCT,1um in diameter,*bone lamella:bone matrix arranged in layers at different direction,-function:,chondrocyte:,substance-osteoid,-structure:LM:,two layers:,-inorganic matter:bone salts,substance-osteoid,-round and in group of 2-8 cells,Hydroxyapatite crystal:,circumferential lamella:,Cells:,-out layer:contain more fiber-protection,-small and immature,two layers:,-small and immature,-appositional growth:,bone collagen fiber-collagenous fiber(type I collagen),cuboidal or low columnar cell,-structure:LM:,/central canal:N,BV,CT,-fiber:type and number of fiber depends on the type of cartilage,membrane-coated,articular surface,rib cartilage,trachea and bronchi,inner layer:,large amount of collagenous fiber bundles,consists of compact bone,/remnant of Haversian,4)growth of cartilage,-structure:LM:,fusiform,small,basophilic cytoplasm,-cell:chondrocyte,two layers:,external ear,epiglottis,ovoid nucleus,slight basophilic cytoplasm,periosteum and endosteum:CT membrane,proteoglycan:,-small and immature,1)Bone tissue,-inorganic matter:bone salts,intervertebral disc,symphysis pubis,*bone lamella:bone matrix arranged in layers at different direction,and bone canaliculus,growing and mature cartilage,long thin processes,3)perichondrium,or circumferential lamella,organ=Cartilage tissue+perichondrium,/central canal:N,BV,CT,-trabeculae:,organ=Cartilage tissue+perichondrium,-inorganic matter:bone salts,consists of compact bone,round nucleus,Cells:,membrane-coated,canaliculus by gap junctions,Cells:,-interstitial growth:,single layer of,central cell:,Fibrous cartilage:,periosteum and endosteum:CT membrane,-cell:chondrocyte,RER,mito.,*perforating canal:,/central canal:N,BV,CT,light zone:-under the ruffled border,proteoglycan:,light zone:-under the ruffled border,-interstitial growth:,periosteum and endosteum:CT membrane,-inorganic matter:bone salts,or circumferential lamella,glycosaminoglycan,cells are small and less,*perforating canal:,large amount of collagenous fiber bundles,-Bone marrow:hemopoietic tissue,exist in periosteum and endosteum,periosteum and endosteum:CT membrane,interstitial lamella:,canaliculus by gap junctions,growing and mature cartilage,Cells:,-organic matter:,light zone:-under the ruffled border,-trabeculae:,osteoprogenitor cell:stem cell,-organic matter:,/inner around inner surface of bone,rich in RER,Golgi complex,shaft:,consists of compact bone,a.,circumferential lamella:,/outer concentrically-arranged,/inner around inner surface of bone,-interstitial growth:substan,35,