辅酶一(NAD)与老年化疾病课件

Age-related diseases and cancer Age-related diseases Age-related diseases COENZYME ICOENZYME I精品1Age-related diseases and canceCONTENTSA.NADbiosyntheticpathwaysandmetabolismA.NADbiosyntheticpathwaysandmetabolismB.NADconsumingenzymesinhealthanddiseaseB.NADconsumingenzymesinhealthanddiseaseC.Age-relateddiseasesandcancerC.Age-relateddiseasesandcancerD.MechanismsofNADPrecursorsinhumansandanimalmodelsD.MechanismsofNADPrecursorsinhumansandanimalmodelsE.NADandthehallmarksofagingE.NADandthehallmarksofaging精品2CONTENTSA.NAD biosynthetic paA.A.NADbiosyntheticpathwaysandmetabolism精品3A.NAD biosynthetic pathways anNADbiosyntheticpathwaysandmetabolismNADbiosyntheticpathwaysandmetabolismEricVerdin.(2015).SpecialSection350（6265）:1208-1213.NAD biosynthetic pathways and metabolism in different cellular compartments.精品4NAD biosynthetic pathways and B.B.NADconsumingenzymesinhealthanddisease精品5B.NAD consuming enzymes in heaNADconsumingenzymesinhealthanddiseaseNADconsumingenzymesinhealthanddiseaseEF.Fang,.(2017).NAD+:akeymetabolicregulatorwithgreattherapeuticpotential:1120-1143.NAD availability can influence the activity of three groups of master regulator enzymesthe sirtuins,the PARPs and cyclic ADP-ribose synthases.Each group of enzymes regulate many biological processes and can thus couple changes in NAD levels with a wide range of physiological responses.精品6NAD consuming enzymes in healtC.C.Age-relateddiseasesandcancer精品7C.Age-related diseases and can1980s1980s1930s1930sAge-related diseases and cancer could be the consequence of a decline in NAD+concentrationsAmandaGarrido(2017).Trendincancer181:181-199.Age-relateddiseasesandcancerAge-relateddiseasesandcancerMetabolic syndrome including cardiovascular disorders,type 2 diabetes and obesity,Neurodegenerative diseases such as Alzheimer and Parkinsondiseases,arthritis,and osteoporosis,and cancer are some of the diseases that commonly affect human health during aging.精品81980s1930sAge-related diseasD.D.BenefitsandmechanismsofNADprecursorsinhumansandanimalmodels精品9D.Benefits and mechanisms of NBenefitsandmechanismsofNADprecursorsinBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelshumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品10Benefits and mechanisms of NADBenefitsandmechanismsofNADprecursorsinBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelshumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品11Benefits and mechanisms of NADBenefitsandmechanismsofNADprecursorsinBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelshumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品12Benefits and mechanisms of NADE E.NADandthehallmarksofaging精品13E.NAD and the hallmarks of agiNADandthehallmarksofagingNADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品14NAD and the hallmarks of agingNADandthehallmarksofagingNADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品15NAD and the hallmarks of agingNADandthehallmarksofagingNADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品16NAD and the hallmarks of agingNADandthehallmarksofagingNADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品17NAD and the hallmarks of agingTheEnd精品18TheEnd精品18