肿瘤转移英文-课件

Cancermetastasis1Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTWhatismetastasis?Whatismetastasis?Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTCancerStemCellsmotivate and motivate and maintain the maintain the growth of growth of cancer cellscancer cellspotentialitypotentiality plasticityplasticity make them make them easy to easy to survivesurviveHypothesisoftumormetastasisCancerStemCellsmotivateaThe phases of Cancer metastasisThe mechanism of cancer metastasisMalignant Tumor metastasis pathway Tumor metastasisThe molecules in the metastasis ThephasesofCancermetastasiThe phases of Cancer metastasis俞仁涛Invasion(侵犯)Intravasation（内渗）Extravasation（外渗）ThephasesofCancermetastasiDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTInvasion1.Stablecellmovablecell2.Proteinexpression3.MovementmechanismRelativegenesInvasion1.StablecellDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXT肿瘤转移英文-课件Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTIntravasation1.Angiogenesis2.ImmuneescapeIntravasation1.AngiogenesisDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTExtravasationTheinverseprocessofinvasionExtravasationTheinverseproceTHE PROCESS OF TUMOR METASTASISTHEPROCESSOFTUMORMETASTASIDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTMalignant Tumor metastasis pathway 恶性肿瘤常见的转移途径恶性肿瘤常见的转移途径MalignantTumormetastasispatDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTCommon metastasis pathway 1.lymphaticmetastasis淋巴淋巴道转移道转移2.hematogenousmetastasis血道血道转移转移3.implantationmetastasis种植种植性转移性转移Commonmetastasispathway1.lDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTProcess：cancer cell lymph vessel regional lymph node beyond lymph node hematogenousmetastasis1.LymphaticmetastasizeProcess：cancercellDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXT2.Hematogenousmetastasisulunglunguliverliver2.HematogenousmetastasislunglDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTMetastasis pathway（1 1）Body vein lung Body vein lung（2 2）Portal vein liver Portal vein liver（3 3）pulmonary veins Total body（brain、bone、kidney、adrenal glands）Metastasispathway（1）BodyveiDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXT3.Implantation metastasis ChestCeliacPericardial cavity3.ImplantationmetastasisChesDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTBioremediation生物治生物治疗疗uLowsideeffectsuWiderangeuCleargoalBioremediation生物治疗LowsideeDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTMechanismofcellmetastasisCell adhesion molecule(CAM)Degradation of extracellular matrixMotility of tumor cellsFormation of vessels RegulationofgeneexpressionImmunizationMechanismofcellmetastasisCeDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTCelladhesionmolecule(CAM)vCadherinvIntegrinsvSelectinvIgSFvothersCelladhesionmolecule(CAM)CadDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDegradationofextracellularmatrixDegradationofextracellularDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXT丝氨酸蛋白酶类丝氨酸蛋白酶类 半胱氨酸蛋白酶类（半胱氨酸蛋白酶类（Caspase家族）家族）天冬氨酸蛋白酶类天冬氨酸蛋白酶类 基质金属蛋白酶类（基质金属蛋白酶类（MMPs）DegradationofextracellularmatrixvProteoiytic enzymes(蛋白水解酶蛋白水解酶)溶解溶解ECMECM是肿瘤侵袭和转移的是肿瘤侵袭和转移的天然屏障天然屏障丝氨酸蛋白酶类DegradationofeDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTMotilityoftumorcellsMotilitytypes:RandommovementDirectionalmovementMotilityfactors:AutoecrineparacrineMotilityoftumorcellsMotiDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTFormationofvesselsTumor metastasis relys on the forming of vessels.FormationofvesselsTumormetBrief Introduction to Molecules in Cancer Metastasis肿瘤转移英文-课件Three SectionspTumourangiogenesispDisaggregationpIntravasationThreeSectionsTumourangiogeneDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTTumourangiogenesispTumour angiogenesis has laid the foundation for tumour survival and tumour metastasis.TumourangiogenesisTumourangDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTTumourangiogenesisTumourangiogenesisDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDisaggregationBroken downDisaggregationBrokendownDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDisaggregationUpaCathepsinsMMPsDisaggregationUpaCathepsinsMMPDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDisaggregationDisaggregation