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CasereportCase report ChiefComplaint:Intermittentcoughfor1year，withbloodysputum20daysHistoryofpresentillness:Patienthasbeencoughsputumforabout1yearwithnoobviousIncentives.HissputumwasWhitefoamysputumandwhenpatientwalkingfast,coughwasobviouslyincreasedwhileasalittlerestcanbebebefitforcoughcutting.Thesesymptomsappearintermittentlywithnoformaldiagnosis.Patientcoughedbloodysputum20daysagoandachestCTatlocalhoapitalreported:Leftlowerlobemass,considerlungcancer.Chief Complaint:History of prePastmedicalhistory:previouslyhealthy,nohistoryoftuberculosisandnohistoryofchronicbronchitis,nofood,drugallergies,nohistoryoftrauma,surgeryPersonalhistory:smoking20cigarettesperdaywith40yearshistory,drinkingIrregular.Obstetricalhistory:married,sterileason.Familyhistory:familyhealth,nohepatitis,tuberculosispatientswithouthypertension,diabetes,non-hereditarydisease.Past medical history:previousCTexaminationCT examinationCTexaminationCT examinationCTexaminationCT examinationCTexaminationCT examinationCTexaminationCT examinationCTexaminationCT examinationElectronicbronchoscopyexamination左肺下叶可见腔内肿物，累及左主支气管直至距隆突4个软骨环处，管腔部分堵塞Electronic bronchoscopy examinPathologicaldiagnosisAdenocarcinomaPathological diagnosisAdenocarEGFRgenemutationdetectionEGFR gene mutation detectionEGFRgenemutationdetectionEGFR gene mutation detectionThe treatment principlesIcotinib125mgTidpoThe treatment principlesIcotinCTexaminationaftertwomonthsCT examination after two monthCTexaminationaftertwomonthsCT examination after two monthCTexaminationaftertwomonthsCT examination after two monthCTexaminationaftertwomonthsCT examination after two monthCTexaminationaftertwomonthsCT examination after two monthCTexaminationaftertwomonthsCT examination after two monthContrastContrastBeforetreatmentAftertreatment ContrastContrast Electronicbronchoscopyexamination左肺下叶可见腔内肿物，累及左主支气管直至距隆突7个软骨环处，管腔部分堵塞Electronic bronchoscopy examin Contrast Contrast The treatment principlesThe treatment principles2.Surgical operation2.Surgical operation The surgical indications were performedThe surgical indications were performed Left pneumonectomy surgery(2013.08.06)Left pneumonectomy surgery(2013.08.06)Removal part of esophageal muscularis and part Removal part of esophageal muscularis and part of the pericardiumof the pericardium3.Local chemotherapy3.Local chemotherapy Refused Refused4.Continue Icotinib treatment 4.Continue Icotinib treatment The treatment principles2.SurPathologicaldiagnosisModeratelydifferentiatedadenocarcinoma2*1.5*1.5Bronchialstump（-）4L(0/2)、5(0/2)、6(0/2)、7(2/10)、8(0/1)、10(1/4)pT3N2M0APathological diagnosisModerateFollow-upContinuous administration Icotinib and Continuous administration Icotinib and reviewing monthlyreviewing monthlyWithout local recurrence and metastasisWithout local recurrence and metastasisFollow-upContinuous administrConclusionConclusionThe advanced administration of targeted The advanced administration of targeted medicine can medicine can reduce the risk and reduce the risk and difficulty difficulty of surgeryof surgeryConclusionDiscussion1.1.Targeted medicine Targeted medicine mainly be used for mainly be used for patients with locally advanced lung cancer patients with locally advanced lung cancer who has been received prior chemotherapy or who has been received prior chemotherapy or metastatic non-small cell lung cancer metastatic non-small cell lung cancer patientspatientsTargeted medicine can be Targeted medicine can be another another option ofoption of neoadjuvant?neoadjuvant?2.Male patients with a history of smoking 2.Male patients with a history of smoking also benefit from talso benefit from targeted medicineargeted medicineDiscussion1.Targeted medicine ThankyouforattentionThank you for attention
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