吡咯配体的合成

(CH2 ) 3BrMes|iBu -11 . 11.2+2 . 1R: P h3p Br 2 , S :C H2 Cl2，15 min, rtNOTE:Reactants :2 , Reagents :3 , Solvents :2,Steps :2, Stages :4 , Most stages i n any one step: 22 . 2MeR : H 2 O , r tMeBu- t(CH2)314R : Ph3 PB =2 ,S : CH 2Cl 2 ,15min ,r t J1. 2 R: H2O , rt81%NOTE: R e a c tants: 1, Reagents :2, Solven ts: 1,St e p s :1, St ages: 2向 8- 羟基喹啉的 5 位上接吡咯：先在 8- 羟基喹啉的 5 位上进行氯甲基化，然后再将吡咯与 苄氯反应形成 3 反应路径： 甲醛可用多聚甲醛代替 合成此配体 的目的 在于吡 咯易电聚 合，将得到的配体与金属离子配位， 形成的配合物通过电聚合的方法将其 修饰到玻碳电极表面。进行异相电化学催化反应。H2(p-pyr)TPP:A 25-ml amount of glacial acetic acid was added to 200 mg (151 mmol) of 2,5-dimethoxytetrahydrofuran (Aldrich) and 200 mg(3.30 mmol) of H2(p-NH2)TPP and the resultant solution refluxed with stirring for 1.5 h. A precipitate formed during the reaction. After the mixture was cooled to room temperature, the porphyrin was filtered and washed with methanol and hexane; yield 200 mg (75%). The completeness of the reaction was checked by using IR spectroscopy in KBr pellets. No maxima at about 3400 cm -1were observed for the final product, indicating the absence of stretching vibration for free aromatic amine groups.超氧阴离子 ;superoxide anion性质：需氧生物体内氧分子作为最重要的电子受体在物质代谢过程中被还原成水：O2+4e2H2O，如此利用的氧约占组织耗氧总量的95 %，其余5%的氧在还原过程中由于接受电子数目不等可以形成多种性质活泼的活性氧。氧分子受单一电子还原的产物称为超氧阴离 子o2+eO2 。02是阴离子，又是自縫，性质活泼，具有很强的氧化性和还原性，既是氧化剂，又是还原剂，过量生成可致组织损 伤。在体内主要通过超氧歧化酶清除