表没食子儿茶素没食子酸酯对於老化老鼠血液流变异常之改善评估

表没食子完茶素没食子酸酯封於老化老鼠血液流燮昊常之改善押估Improving Effects of Epigallocatechin-3-gallate on Hemorheological abnormality in Aging Guinea Pigs中文摘要表没食子完茶素没食子酸酯(Epigallocatechin-3-gallate , EGCG)是东景茶中最瞿富的完茶素，同日寺在勤物模型中具有I!著的抗氧化能力。在本研究中，我俯逗撵了自然老化 24偃I月大的天竺鼠做悬勤物寰瞬模型，分别以10、20、30 mg/kg/day EGCG (分别是寰期！ A、B、C) 鬟28天彳爰，来探言寸EGCG封於老化天竺鼠累常血液流燮值的效用。结果示，封於口服用EGCG 10mg/kg/day二十八天的天竺鼠(A 1)的血液流燮参数舆控制群D比较(EGCG 0mg/kg/day) ,她没有明的燮化。但是，富 EGCG的量到逵 20mg/kg/day(B ) , It然在他便号的缸血球聚集度、血液黏度和血液黏弹性上仍没有I!著的差 累，但是缸血球膜的 MDA值始I!著减少(p0.05),似乎表示了缸血球燮形度的上升和缸血 球流抗阻力的减少。而且，在给予老化天竺鼠EGCG 30mg/kg/day (高加t )彳爰，不是血液黏度、血液黏弹性、缸血球聚集或缸血球燮形度等血液流燮参数，都有明的改善。英文摘要Epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, has been shown to have pronounced anti-oxidative activity in animal models. In our study, we selected 24 months old aging guinea pigs as the experimental model, fed with diet containing 10, 20 and 30mg/kg/day of EGCG (experimental groups A, B, and C) for 28 days, respectively, in order to investigate the effects of EGCG on the abnormal hemorheological parameters of the aging guinea pigs.The results showed that blood biochemical parameters of the aging guinea pigs remained unaffected by orally given EGCG for 28 days compared to the controls groups D ( 0mg/kg/day of EGCG). The hemorheological results indicate that aging guinea pigs fed with low dose of EGCG (10mg/kg/day) did not have significant changes in hemorheological parameters compared with the control group. However, as the EGCG content reached to 20mg/kg/day, though there were still no prominent alteration in their erythrocyte aggregation, blood viscosity and blood viscoelasticity, but, the erythrocyte membrane MDA levels of aging guinea pigs started to exhibit significantly reduced (P0.05) that seems to be responsible for the rise in erythrocyte deformability and the reduction in erythrocyte flow resistance. Moreover, the feeding of EGCG at 30mg/kg/day (high dose), significantly improved most of abnormal hemorheological parameters whether blood viscosity, blood viscoelaticity, erythrocyteaggregation or erythrocyte deformability