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单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,*,The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma,徐 智,南京医科大学附属南京第一医院暨,南京市第一医院 肿瘤内科,1,Worldwide incidence of HCC,Blum HE,Spangenberg,HC.,Arch Iran Med,.2007 Jul;10(3):361-71.,Identification of,Yes-associated Protein(YAP),Zender,L.,et al.,Cell,125,1253-67,E,F,G,H,YAP improves cell proliferation,Time(Days),*：,p,0.05,。,YAP induces anchorage-independent growth,MIHA-YAP cells but not MIHA-,Vec,could form colonies in soft-agar.,MIHA-YAP,cells gained advantages in cell migration and invasion.,YAP enhances cellular mobility and invasiveness,IHC results of YAP in HCC,53.7%HCC samples showed nuclear YAP positive.,Clinical association of nuclear YAP in HCC,Clinical association of nuclear YAP and HCC-specific postsurgical recurrence,Kaplan-Meier,Median RFT,：,Nuclear YAP negative:25.8 months,vs.,Nuclear YAP positive,：,12.9,months,Nuclear YAP is an independent prognostic marker for HCC recurrence,Cox Regression,Summary,YAP confers,tumorigenic,and metastatic potentials in,hepatocytes,as evidenced by enhanced aptitudes in cell viability,anchorage-independent growth,migration and invasion.,YAP nuclear accumulation was found in the 53.7%of HCC,correlated with poorer tumor differentiation and higher serum alpha-fetoprotein(AFP)levels.,Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival.,YAP plays an important role in HCC development and progression.,Acknowledgement,新加坡国立大学外科系和药学系,Asso,.Prof.John M.,Luk,香港大学外科系,Prof.Fan S.T.,，,Prof.,Poon,R.T.,and Surgical Tissue Bank,南京市第一医院肿瘤内科,Thank You,
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