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,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,Transition Metal-Catalyzed C-H Bond Activation of Aromatic Compounds,：,Chelation-Assisted Ortho-Functionalization,Outline,Introduction,Catalytic Ortho-Functionalization,Conclusion and Outlook,Introduction,Introduction,Lewis, L. N.;Smith, J. F,J. Am. Chem. Soc.,1986,108, 2728,Introduction,Murai, S.; et al.,Nature,1993,366, 529,Introduction,Advantages,High selectivity,Atom economy,Clean and economical process,Catalytic Ortho-Functionalization,Ortho-Alkylation,Ortho-Arylation,Ortho-Carbonylation,Others,Ortho-Alkylation,Jun, C. H.,Angew.Chem. Int. Ed.,2000,39,3440,Ortho-Alkylation,Ahrendt, K. A.; et al.,Org. Lett,.,2003,5, 1301,Ortho-Alkylation,Thalji, R. K.; et al.,J. Am. Chem. Soc.,2004,126, 7192,Ortho-Alkylation,Chen X.; et al.,J. Am. Chem. Soc.,2006,128, 12634,Ortho-Arylation,Ortho-Arylation,Kakiuchi, F.; et al.,J. Am. Chem. Soc.,2003,125, 1698.,J. Am. Chem. Soc.,2005,127, 5936,Ortho-Arylation,Kakiuchi, F.; et al.,J. Am. Chem. Soc.,2005,127, 5936,Ortho-Arylation,Wan X. B., et al.,J. Am. Chem. Soc,.,2006,128, 7416. Punna S, et al.,Synlett,2004,13, 2351. Rodriguez N.; et al.,J. Org. Chem.,2004,69, 8070. Shi Z J.; et al.,Angew.Chem. Int. Ed.,2007,46,5554,Ortho-Arylation,Ortho-Arylation,Kalyani, D.; et al.,J. Am. Chem. Soc.,2005,127, 7330,Ortho-Arylation,Ortho-Arylation,Ortho-Arylation,Ortho-Arylation,Shabashov, D.; Daugulis, O.,Org. Lett.,2005,7, 3657,Ortho-Carbonylation,Moore, E. J.; et al.,J. Am. Chem. Soc,.,1992,114, 5888,Ortho-Carbonylation,Fukuyama, T.; et al.,J. Org.,Chem,.,1997,62, 5647,Ortho-Silylation,Kakiuchi, F.; et al.,Chem. Lett,.,2001, 422.,Chem. Lett,.,2002, 396,Kakiuchi, F.; et al.,Chem. Lett,.,1995, 681,Jia, C.; et al.,Science,2000,287, 1992,Kuninobu Y.; et al.,Angew.Chem. Int. Ed.,2007,46,6518,Conclusion and Outlook,Outstanding results have been obtained in selectivity and atom economy. These development will help both synthetic and material chemist a great deal,Development of milder, lower temperature reaction conditions,Fine-tuning of catalyst systems to allow for the industrial use,
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