血小板减少性紫癜发病机制 课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,2024/8/24,特发性血小板减少性紫癜（,Idiopathic Thrombocytopenic Purpura, ITP,）,发病机制,2023/8/31特发性血小板减少性紫癜（Idiopath,2024/8/24,发病机制,体液免疫,1,体液免疫因素,自身抗体识别的靶抗原几乎涉及血小板膜表面所有分子(抗血小板糖蛋白,IIb/IIIa,、,Ib/IX,、,Ia/IIa,、,IV,、,VI,和,P-Sel,等)。,结合自身抗体的血小板易被网状内皮系统破坏,自身抗体引起获得性血小板功能异常,自身抗体结合巨核细胞，干扰巨核细胞分化成熟,McMillan,等发现，2/3,ITP,患者血浆能明显抑制巨核细胞生成（2595%）,巨核细胞数量和成熟度均受到抑制。,Chang,等也证实自身抗体明显抑制脐血来源巨核细胞生长,Blood 2004;103:1364-1369,Blood 2003;102:887-895,2023/8/31发病机制体液免疫 1体液免疫因素,2024/8/24,发病机制体液免疫,1,、血小板相关抗体（,platelet-associated immuoglobulin PAIgG,）,Harrington,等,1951,年证实：,27,例,ITP,患者的血浆输给正常志愿者，,16,例,PC,减少,PC,CD8+ T cells.,Trend toward Th1 activation.,primarily,react with GPIIb/IIIa.,Adherent cell (APC) dependent.,2023/8/31T Cell Characteristic,2024/8/24,Approximately 40% of patients with chronic AITP,have no detectible antibodies on their platelets,or in their plasma,.,Why?,How are their platelets being,destroyed?,2023/8/31Approximately 40% of,2024/8/24,Tumor,cell,CTL,2023/8/31TumorCTL,2024/8/24,Anderson et al. Nature Medicine 2003,CD8 cell,Platelet,Lysis (kill),Suggests that a novel therapeutic targeting,cell mediated immunity may benefit some ITP patients,.,2023/8/31Anderson et al. Natur,2024/8/24,Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura,apoptotic resistance of activated T-lymphocytes in patients with active ITP may lead to defective clearance of autoreactive T-lymphocytes through AICD,（,activation induced cell death), which might cause a continued immune destruction of platelets,Olsson B,et al. Thromb Haemost. 2005,2023/8/31Disturbed apoptosis o,2024/8/24,发病机制,3,、雌激素,4,、遗传因素,HLA DRW9,和,HLA DQW3,2023/8/31发病机制3、雌激素,后面内容直接删除就行,资料可以编辑修改使用,资料可以编辑修改使用,资料仅供参考，实际情况实际分析,后面内容直接删除就行,主要经营：,课件设计，文档制作，,网络软件设计、图文设计制作、发布广告等,秉着以优质的服务对待每一位客户，做到让客户满意！,致力于数据挖掘，合同简历、论文写作、,PPT,设计、计划书、策划案、学习课件、各类模板等方方面面，打造全网一站式需求,主要经营：课件设计，文档制作，网络软件设计、图文设计制作、发,感谢您的观看和下载,The user can demonstrate on a projector or computer, or print the presentation and make it into a film to be used in a wider field,感谢您的观看和下载The user can demonstr,