【病毒外文文献】2018 Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential ant

Accepted Manuscript Synthesis biological evaluation and molecular modeling of a novel series of fused 1 2 3 triazoles as potential anti coronavirus agents Konstantina Karypidou Sergio R Ribone Mario A Quevedo Leentje Persoons Christophe Pannecouque Christine Helsen Frank Claessens Wim Dehaen PII S0960 894X 18 30750 9 DOI https doi org 10 1016 j bmcl 2018 09 019 Reference BMCL 26040 To appear in Bioorganic 767 769 23 2 Drosten C G nther S Preiser W Van der Werf S Brodt HR Becker S Rabenau H Panning M 24 Kolesnikova L Fouchier RAM Berger A Burgui re AM Cinatl J Eickmann M Escriou N Grywna K 25 Kramme S Manuguerra JC M ller S Rickerts V St rmer M Vieth S Klenk HD Osterhaus ADME 26 Schmitz H Doerr HW Identification of a novel coronavirus in patients with severe acute respiratory 27 syndrome N Engl J Med 2003 348 1967 1976 DOI https doi org 10 1056 NEJMoa030747 28 3 Kuiken T Fouchier RAM Schutten M Rimmelzwaan GF Van Amerongen G Van Riel D Laman JD De 29 Jong T Van Doornum G Lim W Ling AE 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Tomar S Mielech AM Baker SC Lindsley CW Hodder P Mesecar A Stauffer SR 39 Discovery synthesis and structure based optimization of a series of N tert Butyl 2 N arylamido 40 2 pyridin 3 yl acetamides ML188 as potent noncovalent small molecule inhibitors of the severe acute 41 respiratory syndrome coronavirus SARS CoV 3CL J Med Chem 2013 56 534 546 42 https doi org 10 1021 jm301580n 43 19 Turlington M Chun A Tomar S Eggler A Grum Tokars V Jacobs J Daniels JS Dawson E Saldanha 44 A Chase P Baez Santos YM Lindsley CW Hodder P Mesecar AD Stauffer SR Discovery of 45 N benzo 1 2 3 triazol 1 yl N benzyl acetamido phenyl carboxamides as severe acute respiratory 46 syndrome coronavirus SARS CoV 3CLpro inhibitors Identification of ML300 and noncovalent 47 nanomolar inhibitors with an induced fit binding Bioorg Med Chem Lett 2013 23 6172 6177 48 http doi org 10 1016 j bmcl 2013 08 112 1 20 Gallagher MJ Mann FG The structure and properties of certain polycyclic indolo and 2 quinolinoderivatives Part 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