微通道并行模块化设计制造及规模化制备功能材料

化 工 进 展2017 年第 36 卷增刊 1 CHEMICAL INDUSTRY AND ENGINEERING PR(X；RESS 51 化 工 进 展2017 年第 36 卷增刊 1 CHEMICAL INDUSTRY AND ENGINEERING PR(X；RESS 51 研究开发？化 工 进 展2017 年第 36 卷增刊 1 CHEMICAL INDUSTRY AND ENGINEERING PR(X；RESS 51 通道并行模块化设计制造及规模化制备功能材料韩腾腾.张莉，宣晋.蚩政，徐宏(华东理工大学机械与动力工程学院.化学工1S朕合国家重点实於室.上海200237)摘要：液滴從流控技术可控制备功能微粒材料目苗一直易限于实验实规模产量.制约着规模化的产业总用。本 文基于微通道并行概念以戟童放大为基本原则.设计了八適道并行的缴流控放大模块.模块由位于不同平面 的网相沈依的分配功能区和液滴制备功能区构建组合而成。借助溉光離則技术以PMMA作为基板材料进行加工 制造.实现了规模化制备均匀液滴的冃的。冋时研完了沆迷找制対各个逋道液摘制备过柱的彭响.分析了倣通 道阵列山于流体分配关破问题所产生的放大效应。两种逋道阵列形式对比实脸表明.环形阵列制备出液滴的均 匀性比线性阵列捉高近42.4%主要得益于完全对称的环形阵列减小了结构性因素对流体分配性能的影响.并 借助环形并行模块平台大規模制备了具有广间应用前景的壳聚械傲球平均桂径为540. 59卩mCV值为 2.73%,并行放大模块在提升产童的同时确保了徴球的高单分散性。 关键词：液滴底流控；傲通道并行放大模块化设计$功能材軒中国分类号：TQ 051； TB 34文献标志码：A文章编号:1000-6613 (2017) “4X)51-071X)1： 10. I6O85/j. issn. 1000-6613. 2017-0274Modularized microchannel parallelization design and fabricationfor mass production of functional materialsHAN Tenten ZHANG Li, XUAN J in DONG ZMg XU Hong(State-Key Ijilxratory of Chemical Engineerings School of Mechanical and Power Engineering* East ChinaUniversity of Science and Technology Shanghai 200237. (、hinaAbstract： Advanced material synthesized from niicrofluidic teclinology has been largely restrained into the saile of lalx)ralory sludy hindering its large scale industrial appliaition. Here* kised on channel jxirallelization concept with nurnlx?ring up principle* niicrofluidic large-scde module of eight channels was designed. The module consists of clistribulion layers for two phases and droplet generation layer under different planes. The mochile was fabricated with PMMA substrate using laser microfabrication engraving cquipmcnl. achiesing the large-scale production of uniform droplets* The flow rates of two plvises were investigcitecl on the droplets formation of parallelized channels with sailing effect resulting from the significant problem of fluid distribution Exxrimennl com|)irison of two arrays showed I he circular array with syinrnctrical arraiigenieul improved the size uniformity of 42. 4% cornircd to I lie |xirallel array. Widely applied functiond chitosiin microspheres were also nviss-synthesized with in average diameter of 540. 59/xm and a CV of 2. 73%. The through|)ut was largely improved while maintaining excellent uniformity compared to individual clvmncl.Key words: drop-microfkiidics; microchannel parallelization; scale-up: modularization design; functionnl materials化 工 进 展2017 年第 36 卷增刊 1 CHEMICAL INDUSTRY AND ENGINEERING PR(X；RESS 51 化 工 进 展2017 年第 36 卷增刊 1 CHEMICAL INDUSTRY AND ENGINEERING PR(X；RESS 51 收稿日期：2017-02-22；修改稿日期：2017OH8.基金项目：上海市科学技术委员会資助材料荃因组工程研究院顼 目(16DZ226O6O1).第一作者，韩忖強(1992).男.硕士硏究生.研究方向为做过 俚放大.Email： lutwithy(xi(A .联系人：张罰.教授. 博士生寻师.硏究方向为傲能凍化工过程、高效过程婪缶E- mail： Izlvingccust. cdu. cn