Calcium-Cycling-in-Cardiac-Cells在心肌细胞钙循环课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,Calcium Cycling,in Cardiac Cells,Lin Guo-hua,Cardiac E-C coupling,Slow or L-type Ca,2+,Channels(DHPRs),L-type Ca,2+,Channels,Ca,2+,Release Channel of the Sarcoplasmic,Reticulum(Ryanodine Receptor),cardiac ryanodin receptor,Physiological and pathophysiological regulation,Ca,2+,Pump of the,Sarcoplasmic Reticulum,(SERCA),SERCA,SERCA-PLN complex,Phospholamban,(PLN),&,Sarcolipin,(SLN),The Ca,2+,Pump of the Plasma,Membrane(PMCA),Sodium/Calcium Exchanger(NCX),Troponin C(TnC),Calmodulin(CaM),Calmodulin(CaM),&,Calmodulin Kinase II,(CaMKII),Calmodulin Kinase II(CaMKII),Regulation of Ca Transporters by CaM and CaMKII,frequency-dependent acceleration of,relaxation(FDAR),Calsequestrin,(CSQ),Organization of EC coupling elements,Integrative Analysis of Calcium,Cycling in Cardiac Muscle,Ca,2+,i,Transient in Heart Cell,Ca,2+,I,Transient,Ca,2+,i,sparks,&,Ca,2+,Requirements for Activation of Myofilaments,Autoregulation of SR Ca,2+,Content,Changes of sarcolemmal fluxes and SR Ca,Ca,2+,release during potentiation,of CICR by caffeine(500 mmol/L),Modulation of the RyR,relationships between the various Ca,2+,fluxes,Ca,2+,Influx During the Cardiac AP,Ca,2+,Removal From,the Cytosol During,Cardiac Relaxation,Frequency-dependent changes in the fraction of Ca release that is taken back up by the SR,Measurement of SR,Ca,2+,content and,forcefrequency,relationship.,force frequency relation,Frequency-dependence of isometric twitch force(twitch)and rapid,cooling contractures(RCC)in nonfailing and failing human,myocardium,Relationship between NCX and,SERCA protein levels and in non-,failing and failing human myocardium,Caffeine contractures in isolated rabbit myocytes,following adenoviral gene transfer of LacZ and NCX,Frequency-dependent changes in twitch force,aequorin light signals RCCs in huma atrial muscles,(,A,)and ventricular muscles(,B,).,Steady-state twitches,postrest twitches,and,RCCs in isolated human,atrial myocardium.,Rapid Cooling Contracture,Paired RCCs and Ca,2+,Reuptake Into the SR,Rest-dependent changes in the amplitudes of twitch force and,RCCs)in human atrial myocardium(A)and ventricular muscles(B),postrest potentiation&postrest decay,restitution,postextrasystolic,potentiation,Ca,2+,Restitution of the Ca transient,