新发房颤的急诊处理课件

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,新发房颤的急诊处理,新发房颤的急诊处理,房颤分类,初发房颤,阵发性房颤,持续性房颤,持久性房颤,慢性房颤,除此之外，因脑血栓或其他原因住院而发现房颤，患者无明显症状的房颤定义为沉默性房颤。,房颤分类初发房颤,名称,临床特点,心律失常类型,初发房颤,有症状的（首次发作）,无症状的（首次发现）,发生时间不明（首次发现）,可复发，也可不,复发,阵发性房颤,持续时间,7d,（常,7d,非自限性,反复发作,持久性房颤,持续时间,1,年,永久性房颤,不能终止的,终止后又复发的,没有转复愿望的,持续永久性,名称临床特点心律失常类型初发房颤有症状的（首次发作）无症,AF,发病率,Framingham,研究表明，在,50,岁,60,岁、,60,岁,70,岁及,70,岁,80,岁人群中房颤发病率分别为,0.7%,、,3.5%,和,6.6%,，而在,80,岁人群中发病率高达,16.3%,。同时，男性发病率远高于女性，,70,80,岁男性发病率为,9.1%,，为该年龄组女性的,2,倍；,80,岁男性发病率高达,21.9%,，而女性为,12.5%,。,P A Wolf,et.al,Atrial fibrillation as an independent risk factor for stroke:the Framingham Study.,AF发病率Framingham研究表明，在50岁60岁、6,房颤，脑部的潜在威胁,Compared with subjects free of these conditions,the age-adjusted incidence of stroke was more than doubled in the presence of coronary heart disease(p less than 0.001)and more than trebled in the presence of,hypertension,(p less than 0.001).There was a more than fourfold excess of stroke in subjects with cardiac failure(p less than 0.001)and a near fivefold excess when atrial fibrillation was present(p less than 0.001).In persons with coronary heart disease or cardiac failure,atrial fibrillation doubled the stroke risk in men and trebled the risk in women.With increasing age the effects of hypertension,coronary heart disease,and cardiac failure on the risk of stroke became progressively weaker(p less than 0.05).Advancing age,however,did not reduce the significant impact of atrial fibrillation.For persons aged 80-89 years,atrial fibrillation was the sole cardiovascular condition to exert an independent effect on stroke incidence(p less than 0.001).The attributable risk of stroke for all cardiovascular contributors decreased with age except for atrial fibrillation,for which the attributable risk increased significantly(p less than 0.01),rising from 1.5%for those aged 50-59 years to 23.5%for those aged 80-89 years.While these findings highlight the impact of each cardiovascular condition on the risk of stroke,the data suggest that the elderly are particularly vulnerable to stroke when atrial fibrillation is present.(ABSTRACT TRUNCATED AT 250 WORDS),1/3,未曾接受治疗的,AF,病人会出现脑卒中,AF,患者出现脑卒中的风险是无,AF,患者的,4,倍,伴随心衰或者冠心病患者中，,AF,使男性发生脑卒中的风险增加,1,倍，使女性发生脑卒中的风险增加,2,倍。,AF,是唯一随年龄递增的脑卒中特特异心血管危险性因素。,房颤，脑部的潜在威胁Compared with subjec,新发房颤的急诊处理课件,急性脑栓塞,心源性占,60-70%,起病急骤，以秒计；,既往有各种类型的心脏病、心房纤颤、心肌病、心肌梗死等病史，需注意特发性房颤造成脑栓塞占,2.7,；昏迷约占,33,，抽搐高达,25,，偏瘫常较完全；,有时可发现其他内脏或肢体的栓塞；,脑脊液检查压力正常或略高，常规检查可能有红细胞，说明有栓塞性出血的可能性；,头颅,CT,扫 描检查和脑血栓形成相仿，但有时脑水肿较明显；有时在低密度区中有高密度灶存在，说明有栓塞性出血；有时可见多个低密度区，说明有多发性脑栓塞。,急性脑栓塞心源性占60-70%,AF,合并脑卒中患者预后,Saposnik G,et,al,Atrial Fibrillation in Ischemic Stroke:Predicting Response to Thrombolysis and Clinical Outcomes.Stroke.2012 Nov 20.,Among 12 686 patients with an acute ischemic stroke,2185(17.2%)had AF.Overall,AF patients had higher risk of death at 30 days(22.3%versus 10.2%;P0.0001),1 year(37.1%versus 19.5%;P0.0001)and death or disability at discharge(69.7%versus 54.7%;P0.0001)compared with non-AF patients.After adjustment,thrombolysis was associated with a favorable outcome for patients without AF(relative risk,1.18;95%CI,1.10-1.27),but no benefit was observed for patients with AF(relative risk,0.91;95%CI,0.71-1.17).There was a modestly increased risk of intracranial hemorrhage(any type)(16.5%versus 11.6%;relative risk,1.42;95%CI,1.05-1.91)after thrombolysis among AF compared with non-AF patients.In the logistic regression analysis,there was an interaction between tPA and iScore for a favorable outcome(P-value interaction 0.001).The interaction also was significant(P0.0012)among patients without AF,but did not reach significance(P=0.17)in patients with AF.,在缺血性脑卒中患者，,17.2%,有,AF,病史,在脑卒中患者中，对比于无,AF,的病人，,AF,患者发病一月，一年内死亡率更高。,在脑卒中患者中，对比于无,AF,的病人，伴有,AF,的患者致残率更高。,在脑卒中患者中，由于改善了溶栓治疗，可以使无合并,AF,患者相关风险减低，但是这对合并,AF,的患者并没有明显改善。在溶栓治疗后，合并,AF,的患者出现颅内出血的风险较其他患者升高。,AF合并脑卒中患者预后Saposnik G,et,al,“低危”患者并不真正低危,在使用,20,年后，,ChADS,2,的限制性日益受到重视。,某些脑卒中高危因素并未曾纳入到,ChADS,2,评分中。,很多被认为是低危的人群（,ChADS,2,=0,）患者，发生脑卒中的危险为,1.5%/,年。因此，,ChADS,2,=0,的“低危”患者并不真正低危。,Gage BF,et al,Validation of clinical classification schemes for predicting stroke:results from theNational Registry of Atrial Fibrillation.JAMA.2001 Jun 13;285(22):2864-70.,“低危”患者并不真正低危在使用20年后，ChADS2 的限,血管病作为一个独立脑卒中影响因子，在旧的,ChADS,2,中并没有体现。,AF,患者发生中风的概率会在,65,岁之后会增高，在,75,岁之后，出现中风的风险甚至会更高，但在,CHADS2,中，没有体现年龄分级。,血管病作为一个独立脑卒中影响因子，在旧的ChADS2,Olesen JB et al,Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation:nationwide cohort study.BMJ.2011 Jan 31;342:d124.doi:10.1136/bmj.d124.,Olesen JB et al,Validation of,CHADS2,CHA2DS2-VASc,Congestive HF or LVEF 40%,1,1,Hypentension,1,1,Age 75 years,1,2,Diabetes mellitus,1,1,Stoke,TIA,or thrombo-embolisom,2,2,Vascular diseasev(previous myocardial infarction,peripheral artery disease,or aortic plaque),1,Age 6574 years,1,Sex category(i.e.female sex),1,CHADS2CHA2DS2-VAScCongestive H,关于女性作为新的脑卒中危险因素的几点说明,有研究表明女性作为一个独立高危因素,但有其他的证据表明若“年龄少于,65,，并且没有其他并发症”，则女性不作为一个独立的危险因素。,同时，在满足“年龄少于