FunctionalandMolecularResponsesofCadmiuminthe功能在镉和分子反应

Klicka hr fr att ndra format,Klicka hr fr att ndra format p bakgrundstexten,Niv tv,Niv tre,Niv fyra,Niv fem,*,An Experimental Model of Human Absorptive Enterocytes(Caco-2)to Assess the Bioavailability of Various Metals,Jonas Tallkvist,Department of Biomedical Sciences and Veterinary Public Health,Division of Pathology,Pharmacology and Toxicology,Swedish University of Agricultural Sciences,Uppsala,Sweden,MITF 071018,Bioavailability,The fraction of ingested metal that reaches the systemic circulation,Factors Influencing Bioavailability,Dose,Age,pH,Gastrointestinal contents,Nutritional status,Disease,Metals Investigated in Caco-2 Cells,V,Co,Fe,Mn,Ca,Cu,Cd,Zn,Ni,Pb,Cr,Mg,Routes of Metal Absorption,Basement membrane,Blood vessel,Mucosal/apical side,Blood/basolateral side,Enterocytes,Active,Passive,The Caco-2 Cell Model,Apical chamber,Basolateral chamber,Permeable filter support,Caco-2 cells,Cadmium Absorption,Zalups and Ahmad(2003)Toxcol Appl Pharm,186,3,Tallkvist,et al,.,(2001)Tox Lett,122,171,Correlation Between DMT1 Expression and Cd Transport in Caco-2 Cells,Summary,The Caco-2 cell model provides a useful tool to assess the bioavailability of metals at various defined experimental conditions.,The Caco-2 cell model offers the possibility to gain insight into molecular mechanisms implicated in the bioavailability of metals.,Thank-You for Your Attention!,