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单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,2015.8,Institute of Clinical Medicine,Renmin Hospital,Junming Tang,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,UB-MSC:the new gold standard,to treat several,human,diseases,especially autoimmune diseases,Institute of Clinical Medicine,Renmin Hospital,Hubei University of Medicine,Junming Tang,2015.8,UB-MSC:the new gold standard,Outline,一、,Definition,二、,Characteristics,三、,Classification,四、,Pathogenesis,五、,Traditional therapy,六、,Biotherapy(antibody,、,vaccine,、,gene therapy),七、,Cell therapy(DC,、,HSC,、,MSC),Outline一、Definition,一、,Definition,Autoimmunity,refer to the immune responses to self cells or self components.,Autoimmune disease,refer to the disease state resulted from immune responses directed against self cells or self components.,一、Definition Autoimmunity refe,二、,Characteristics,Autoimmune antibody and(or)autoreactive T lymphocyte can be detected.,Autoimmune antibody and(or)autoreactive T lymphocyte mediate immune response which lead to damage or functional disturbance,The turnover of pathogenetic condition relate with autoimmune response intensity,Recurrent attacks and chronic,二、Characteristics Autoimmune a,三、,Classification,Organ-specific autoimmune disease,Graves,disease,、,insulin-dependent diabetes mellitus,Systemic autoimmune disease,systemic lupus erythematosus,三、ClassificationOrgan-specific,四、,Pathogenesis,Autoimmune antibody,Disfunction,immunologic system(autoreactive T lymphocyte),Genetics and endocrine,四、PathogenesisAutoimmune antib,Examples of Human Autoimmune Diseases with Possible Molecular Mimicry as a Mechanism,Clin Rev Allergy Immunol.2012;42(1):102C11,Examples of Human Autoimmune D,类别,病名,自身抗原,非器官特异性,系统性红斑狼疮,胞核成分（,DNA,DNP,RNP,Sm,）,类风湿性关节炎,变性,IgG,类风湿相关的核抗原,干燥综合征,细胞核（,SS-A,SS-B,）,唾液腺管,胞浆线粒体,微粒体,红细胞,血小板,混合性结缔组织病,细胞核（,RNP,）,器官特异性,乔本甲状腺炎,甲状腺球蛋白、微粒体,Graves,病,甲状腺细胞表面,THS,受体,Addison,病,肾上腺皮质细胞,幼年型糖尿病,胰岛细胞,萎缩性胃炎,胃壁细胞,溃疡性结肠炎,结肠上皮细胞,原发性胆汁性肝硬化,胆小管细胞、线粒体,重症肌无力,乙酰胆碱受体,自身免疫性溶血性贫血,红细胞,特发性血小板减少性紫癜,血小板,常见自身免疫病,类别病名自身抗原非器官特异性系统性红斑狼疮胞核成分（D,五、,Traditional therapy,General therapy,Cortisone,Immune inhibitors,Others,五、Traditional therapyGeneral t,六、,Biotherapy,Antibody,Vaccine,Pharmaceutical Biotechnology 2012,19(4):364,368.ChineseJournalofNewDrugs2011,20(8),六、BiotherapyAntibodyPharmaceut,How to better,solve the suffering of patients,New ways,How to better solve the suf,七、,Gene and Cell therapy,DC,、,NK,、,CIK,、,B,、,T,、,LAK,Stem cells(HSC,、,MSC.,）,七、Gene and Cell therapyDC、NK、C,八、,Stem Cell therapy for AID,1.Definition&Historic landmarks,2.Cell types:MSC origin and,3.Cell harvest,culture and store,4.Delivery method,5.Comparative Evaluation,6.Animal experimental,7.Mechanism,8.Clinical experimental,9.Conclusion,八、Stem Cell therapy for AID1.D,1.Stem cells,1.Stem cells,15,Historic landmarks in the field of stem cell biology,Circ Res.2014;114:21-27.),15Historic landmarks in the fi,2.Cell types,16,2.Cell types16,MSC:origin and biological traits,http:/ Nombela-Arrieta,Nature Reviews Molecular Cell Biology 12,126-131(2011),Synovium,Cartilage,Dental pulp,Bone marrow,Kidney,Pancreas,Adipose tissue,Muscle,Brain,liver,Tonsil,Placenta,Umbilical Cord,Thymus,Pericytes,Amniotic fluid,MSC:origin and biological tra,3.Isolation,culture store of mesenchymal stem cells from Whartons jelly,J.Biomedical Science and Engineering,2012,5,580-586,Cryobiology.2014 Jun;68(3):467-72.,Current Stem Cell Research&Therapy,2013,8,144-155,3.Isolation,culture store of,4.Delivery methods,PMID:26068030,4.Delivery methodsPMID:260680,5.Comparative Evaluation of different MSCs,J Immunol Res.2015:394917.,5.Comparative Evaluation of di,The advantages of UB-MSCs,Stem Cells International,2013,246134,The advantages of UB-MSCsStem,Table 1:Phenotypic profile of WJ-MSCs compared to MSCs from other sources,Table 1:Phenotypic profile of,Table 2:Transcriptomic profile of WJ-MSCs compared to MSCs from other sources,Table 2:Transcriptomic profil,Table 2:Transcriptomic profile of WJ-MSCs compared to MSCs from other sources,Table 2:Transcriptomic profil,The differentiation advantages of WJ-MSCs compared to MSCs from other sources,Tissue Eng Part B Rev.2014 Oct;20(5):523-44.,The differentiation advantages,Better:autologous/allogenic?,Allogenic healthy BM-MSC,UB-MSC,Cellular Immunology 293(2015)113121,Better:autologous/allogenic?A,Summary,.,1.Umbilical cord derived MSCs are more primitive,proliferative,regenerative,homing and immuno-suppressive than their adult counterparts,2.Healthy UB-MSC is better than MSC from patient-self,Summary.1.Umbilical cord der,
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