002--高热病控制原理 (NXPowerLite)

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,高热病控制原理解析,喻正军 博士,华中农业大学动物传染病实验室,扬翔研究院猪病检测中心,山顶上住有农夫甲，养有一只母猪。山下农夫乙养有一只公猪。,第一天：,农夫甲打电话给农夫乙：老兄，我家母猪发情了，借您家公猪用用，生小猪后，送两只为报酬。,于是农夫乙用手推车将公猪推到山顶去,.?,第二天：,农夫甲又来电：老兄，一次不保险可生出小猪，今天再追加一剂，如何？于是又再重演一次。,第三天：,当农夫乙起床开门一看，公猪已面带微笑的坐在手推车上了。农夫乙说：“你还真积极，人家去找扬翔了！”。,哈哈哈！,母猪发情找扬翔,扬翔，品改专家！,目 录,临床症状,高热病原病因分析,预防控制原理解析,预防控制方案,耳朵出血发绀,神经系统,从脑组织可分离和检测到,PRRSV,、临床上可见神经症状的发病猪,目 录,临床症状,高热病原病因分析,预防控制原理解析,预防控制方案,高热病后，,脏器衰竭,现象普遍,1,、,母猪繁殖障碍多；,/,乏情、返情、产科病，卵巢损伤,2,、,产程延长,，,初乳摄入不均,；,/,母猪健康的重要标志,3,、,哺乳猪非常,难养,；,/,继续控制用药,4,、,保育猪,死亡率高,；,/,呼吸、肠道,5,、,生长肥育猪磕磕碰碰！,/,时有咳、喘、痢，低,烧，猝死，生长不良。,/,非典型症侯群,免疫损伤是一切问题的根源！,/,圆,、,蓝,病因分析,高热病,系列混合感染,2006-2008,年，六千多份样品，蓝耳病阳性率：,42.4%,，变异株阳性率：,32.7,。圆环病毒（,PCV2,）阳性率：,23.8,。,巴氏杆菌,鲜血平板培养,麦康凯培养,大肠杆菌,链球菌,链球菌培养,病料总数：,340,份,2008,年某省数据,特别关注,病因：,发烧,+,继发感染,+,免疫系统破坏,体温观察,药物预防高致病性猪蓝耳病实验体温变化情况,分组号：,A,组，空白对照组,分组号：,a,组，使用饲料添加药物,体温,猪编号,猪编号,攻毒后天数,A1,号猪,A2,号猪,A3,号猪,A4,号猪,A5,号猪,a1,号猪,a2,号猪,a3,号猪,a4,号猪,0,39.8,39.7,40,39.9,39.8,40.0,40.1,40.1,40.1,1,39.5,39.5,39.6,38.4,39.5,39.4,40.0,40.1,40.0,2,39.6,39.5,40,39.4,39.5,39.3,39.6,39.8,40.2,3,40.3,41.6,41.4,40.3,41.7,39.6,39.4,39.6,39.7,4,40.8,41.5,40.5,41,41.5,39.4,39.6,39.4,39.5,5,40,41,40.5,40.5,40.1,39.7,39.6,39.7,39.7,6,40.5,40,40.7,39.6,40.6,39.5,39.5,39.7,40.0,7,41.8,41.8,41.5,40.2,41.8,39.8,39.6,39.8,39.8,8,41.5,39.4,40.8,40.3,40.1,39.7,39.8,39.7,39.8,9,41,40,40.4,40.5,40.6,39.8,39.7,39.8,39.9,10,41.8,40.5,39.7,40.7,37.2,39.8,39.7,39.8,40.0,11,41,39.8,40,40.7,死,39.6,39.8,39.7,39.7,12,死,40,39.8,40.6,39.6,39.4,39.7,39.7,13,39.6,40,39.8,39.5,39.5,39.5,39.6,14,39.8,39.8,39.5,39.6,39.6,39.7,39.5,15,39.8,39.8,39.8,39.4,39.7,39.6,39.7,16,39.5,39.6,39.5,39.5,39.8,39.7,39.8,17,39.6,39.8,39.6,39.6,39.7,39.8,39.7,18,39.8,39.8,39.8,39.7,39.6,39.6,39.6,19,39.8,39.5,39.8,39.8,39.7,39.7,39.8,20,39.5,39.6,40.2,39.7,39.8,39.6,39.7,21,39.8,39.8,40.2,39.8,39.7,39.7,39.8,免疫力受损，免疫系统受破坏，,使得继发感染、混合感染更加严重。,正常巨噬细胞 崩解的巨噬细胞 正常肺脏组织 病变肺脏组织,目 录,临床症状,高热病原病因分析,预防控制原理解析,预防控制方案,蓝耳病毒的感染,哺乳期,怀孕期,保育期,育肥期,胎儿,胎盘,PRRSV,母猪,症状：发烧、嗜睡、厌食、无乳、发情不顺,链球菌、,TGE,圆环病毒,圆环病毒、,猪瘟,沙氏杆菌、巴氏杆菌,副嗜血杆菌,圆环病毒、,附红细胞体,放线杆菌,AP,仔猪,泌乳,PRRSV,保育猪,PRRSV,肥猪,PRRSV,死胎、木乃伊胎,晚期流产,呼吸症状、肺炎,下痢、脐带出血,免疫下降,、死亡,化脓性脑炎,肺炎、,PDWN,虚弱,、死亡,呼吸道症状,整体免疫下降,肺炎,高热病控制方案,查清病原,？,实验室可以为你做什么？,判断何种疾病,判断发病,进程,如何懂得看,解剖,以,方案,去解决问题,高热病控制方案,采取步骤,分清主次,1,、,停止死亡：,A,、,葡萄糖：防止低血糖死亡；,C,、,退热药：极端高烧时；,B,、,小苏打：纠正酸中毒；,D,、,抗应激：别雪上加霜。,2,、控制细菌：,A,、,巴氏、副猪、链球菌等、放线杆菌,。,/,药物或菌苗,。,3,、做好免疫：,A,、,猪瘟,/,伪狂犬；,B,、,脾淋苗,/,基因缺失苗。,4,、控制蓝耳：,A,、,不能强制免疫；,B,、,抗病毒免疫。,操作方案：控制继发感染，缓解临床症状,混饮：,，,电解质、小苏打：直接致死因素是电解质紊乱，高烧极易致酸中毒。白天使用,A,营养补充剂；,，,多维、葡萄糖、氨基酸：多维抗应激；葡萄糖防止绝食下的低血；糖猝死；氨基酸的作用是改善体质。赖氨酸 蛋氨酸。晚上使用,B,营养补充剂。,混饲：,药物应急包：每包拌料,1000,斤，连用,5,天。,注射：,重症，或饮水不足时：,发病后三天内，抗病毒：,HB-98,+,替米考星,+,氟苯尼考,+,退烧,1,号,（扬翔研究院制，内部使用），,随后五天，控制继发感染：替米考星,+,氟苯尼考,+,退烧,1,号,最后，抗病毒：,HB-98+,退烧,1,号,注射；,备注：,HB-98,为华中农大研制的伪狂犬基因工程缺失疫苗。,值得提醒的是：,安乃近、氨基比林虽有良好的解热镇痛作用,但副作用明显,均可引起骨髓抑制,导致粒细胞减少和再生障碍性贫血,并可引起过敏反应,。此外,氨基比林在胃酸条件下还可与食物发生作用而形成亚硝胺致癌物质,现已不单用,仅用于某些复方制剂,;,安乃近肌注亦可引起肌肉萎缩及局部糜烂。,高热病预防方案,做好饲养管理,做好生物安全,做好疫苗免疫,做好药物保健,免疫程序,产房仔猪：,0,日龄 猪瘟细胞苗？,1,头份,0,日龄 “一口福”,1-3ml,1,日龄,HB-98 1,头份滴鼻,14-16,日龄 副猪嗜血杆菌（科前）,1,头份,28,日龄 猪瘟细胞苗,3,头份,保育猪：,35,日龄,HB-98 1,头份,42,日龄 副嗜血杆菌（科前）,1,头份,60,日龄 猪瘟细胞苗,4,头份,70,日龄 科前,HB-98 1,头份,残次,一般,饲养管理,产房仔猪：,0,日龄 猪瘟细胞苗？,1,头份,0,日龄 “一口福”,1-3ml,1,日龄,HB-98 1,头份滴鼻,14-16,日龄,特定病原菌苗,2ml,21,日龄,圆环病毒苗,（何教授研制）,1,头份,28,日龄 猪瘟细胞苗,3,头份,保育猪：,35,日龄,HB-98 1,头份,42,日龄,特定病原菌苗,2ml,60,日龄 猪瘟细胞苗,4,头份,70,日龄,HB-98 1,头份,残次,很高,免疫程序,略,做好药物保健：,药物保健的原则,怎样保健,治疗,PRV,预防,PRV,干扰素,进攻与防守,检测结果记录表,送样日期,:,检测报告编号,:20100109,检测地点,:,广西扬翔农牧公司猪病检测中心,实验编号,原始编号,猪瘟抗体,(ELISA),伪狂犬免疫抗体,(ELISA),伪狂犬野毒抗体,(ELISA),蓝耳病病毒,(PCR),链球菌抗体,(ELISA),1,1,0.036,0.253,-0.218,+,0.110,2,2,0.089,0.328,0.269,0.126,3,3,0.526,0.402,0.091,0.117,4,4,-0.044,0.345,0.077,+,0.295,5,5,0.241,0.328,0.160,0.697,6,6,0.310,0.966,0.038,0.199,7,7,0.955,0.276,0.180,+,0.714,8,8,0.422,0.293,0.123,0.176,9,9,0.298,0.241,0.150,0.730,10,10,0.653,0.333,0.107,+,0.760,11,11,0.685,0.603,0.118,0.610,12,12,0.682,0.333,0.077,0.684,5,月,18,号,实 战,13,13,0.217,0.299,0.099,+,1.284,14,14,0.265,0.391,0.074,0.093,15,15,0.015,0.299,0.069,0.193,16,16,-0.021,0.523,0.067,+,0.143,17,17,0.483,0.310,0.476,0.135,18,18,0.608,0.264,0.103,0.523,19,19,0.008,0.241,0.233,+,0.861,20,20,0.060,0.276,0.075,0.441,21,22,0.079,0.259,0.138,0.183,22,23,0.536,0.241,0.118,+,0.870,23,24,0.517,0.241,0.198,0.949,24,25,0.367,0.259,0.134,1.307,25,26,0.472,0.218,0.146,+,0.883,26,27,0.383,0.247,0.158,1.388,27,28,0.157,0.259,0.135,0.742,28,29,-0.009,0.230,0.251,+,0.914,29,30,0.173,0.270,0.060,1.216,备注：猪瘟抗体,0.40,判为阳性,0.30,判为阴性，之间为可疑。伪狂犬免疫抗体,0.60,判为阳性,0.70,判为阴性，之间为可疑。伪狂犬野毒抗体,0.45,判为阳性,0.40,判为阴性，之间为可疑。链球菌抗体,0.35,判为阳性，,0.35,判为阴性。,分离部位,分离细菌,备注,1,号肺脏,？,2,号肺脏,巴氏杆菌,少量,3,号肺脏,副猪嗜血杆菌,纯且多,4,号肺脏,SS,链球菌,纯且多,5,号肺脏,6,号肺脏,副猪嗜血杆菌,巴氏杆菌,纯且多,纯且多,7,号肺脏,Ss,，,pm,Pm,纯多,8,号肺脏,？,5,月,26,号,6,月,6,号,