抗菌作用机制及抗菌活性

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,拜复乐抗菌作用机制及抗菌活性,常用抗菌药物,MIC,90,(mg/L),PSSP,PISP,PRSP,流感嗜血杆菌,卡他莫拉菌,肺炎克雷伯菌,厌氧消化链球菌,脆弱拟杆菌,莫西沙星,0.25,0.5,0.25,0.125,0.125,1,0.25,8,左氧氟沙星,2,2,4,0.25,1,4,0.5,16,头孢克洛,-,-,-,-,16,-,-,-,头孢曲松,0.5,1,4,8,2,128,-,-,头孢吡肟,0.25,0.5,1,1,1,-,-,-,1,、王睿,.,等，,Chin J Lab Med.2004,，,27(11):739,746,。,2,、,Ellie JC, et al.Antimicrob.Agents Chemother. 2006; 50: 148-155.,PSSP,：青霉素敏感肺炎链球菌；,PISP,：青霉素中介肺炎链球菌；,PRSP,：青霉素耐药肺炎链球菌；：研究中未测定或无活性。,莫西沙星广谱覆盖常见致病菌,抗菌药,MRSA,*,PSSP,*,PISP,*,-,溶血性链球菌,*,-,溶血性链球菌,*,莫西沙星,4,0.25,0.25,0.5,1,左氧沙星,4,2,4,-,1,头孢曲松,128,0.5,4,-,-,阿奇霉素,128,32,64,-,-,*Chin J Lab Med, 2004,；,27(11):739-746.,*Eur J Clin Microbiol Infect Dis(2003)22:203-221.,不同抗菌药物对,G,+,的,MIC,90,(g/ml),MRSA:,耐甲氧苯青霉素金黄色葡萄球菌,PSSP:,青霉素敏感的肺炎链球菌,PISP:,青霉素中介的肺炎链球菌,比较常见抗菌药物对,G,+,菌的抗菌活性,抗菌药物,PSSP(%),PISP(%),PRSP(%),阿莫西林,/,克拉维酸,99.5,90.6,53.9,头孢克洛,91.3,6.2,2.9,头孢丙烯,98.2,18.8,2.9,头孢曲松,100,87.5,58.8,阿奇霉素,11.9,7.3,0,左氧氟沙星,100,96.9,100,莫西沙星,100,97.9,100,王辉等。中华检验医学杂志。,2007;11:1242-1247,。,莫西沙星对肺炎链球菌保持强大活性,