从基因到天然产物生物合成ppt课件

The reemergence of natural products for drug discovery in the genomics era药物基因组学教研室药物基因组学教研室解鸿波解鸿波The reemergence of natural prNatural products and drug discoveryNatural products and genomicsFuture directions and outlookSources of Natural products1234Natural products and drug discWhat are natural products?1.Sources of Natural productsWhat are natural products?1.SWhat are natural products?1.Sources of Natural productsWhat are natural products?1.S从基因到天然产物生物合成ppt课件从基因到天然产物生物合成ppt课件从基因到天然产物生物合成ppt课件Artemisinin2.Natural products and drug discoveryArtemisinin2.Natural productsMorphineQuininePaclitaxelMorphineQuininePaclitaxel6%27%25%5%37%All small molecule new chemical entities6%27%25%5%37%All small moleculCommerciallyavailablechemical space22 x 106 compoundsNatural product universe16 x 104 compoundsCommerciallyNatural product un Natural-product databasesDatabaseNumber of entriesAdditional informationSuper Natural II355,0002D structures with vendor informationUniversal Natural Product Database197,2013D structures assembled from other databasesChinese Natural Product Database53,000Has been used in virtual screeniSMART20,000From traditional Chinese medicinesAfroDb1,000From African medicinal plants Natural-product databasesDataInteractions between drug and targetInteractions between drug and 3.Natural products and genomics3.Natural products and genomiInsights into the BiosynthesisInsights into the BiosynthesisInsights into the BiosynthesisInsights into the BiosynthesisGene clusterGene cluster从基因到天然产物生物合成ppt课件Bioinformatics toolsantiSMASH 3.0Bioinformatics toolsantiSMASH 从基因到天然产物生物合成ppt课件从基因到天然产物生物合成ppt课件Discover new drug leadsDiscover new drug leadsDiscover new drug leadsDiscover new drug leadsPromoter replacements and gene deletionsPromoter replacements and gene4.Future directions and outlook“There was an intrinsic belief in the value of the molecules were seeking.”Gregory Verdine4.Future directions and outlo从基因到天然产物生物合成ppt课件