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*, M.D., Ph.D.CURRICULUM VITAE*, M.D., Ph.D.Address: Department of Neurology, * l Hospital*, Beijing *, P. R. ChinaPhone:*E-mail: *Research objectives：l Vascular pathology in stroke, l Genetic research in CMT, l Functional MR in strokel Intra-arterial/venous thrombolysis in acute cerebral infarctionCAREER AIMSl Short-term: To procure a post-doctoral vacancy abroad for 1 or 2 years to broaden my view, to enhance my skills and to acquire the ability to meet the requirement of higher standard of work. My interests are: Pathology in AD and VaD Genetic research in CMT and CADASIL Functional MR in Strokel Long-term: To cooperate with more experts and became more and more expert in Neurological research. EDUCATIONl 2003-2006: Ph.D. in Neurology, The * University, Chongqing, P. R. China Thesis: * Advisor: Prof.* In this study, I *l 2000-2003: M.S. studies in Neurology, The * University, Chongqing, P. R. China Thesis: * Advisor: Prof. * This project is to analysis *l 1995-2000: M.D. in clinical medicine, The * University, Chongqing, P. R. ChinaAPPOINTMENTSl 01/2009- Present: Chief-Resident, Department of Neurology, *Hospitall 10/2007-Present: Instructor, Physician-in-charge, Department of Neurology, *Hospitall 10/2000-10/2007: Physician-resident, Department of Neurology, * HospitalHONORS AND AWARDSl 2007: Excellent Physician-resident, * Hospitall 2010: Excellent Chief-Resident, Beijing Military General HospitalRESEARCH EXPERIENCEl Principal in a project supported by the National Science Foundation of China (Grant# 30800357). This project, which will be finished in July, 2011, is to study the relationship between phenotype switch of VSMC and Notch3. l Main participator in a project supported by National Science Foundation of China (Grant# 30470609), In this project, I have found when the FLNmRNA in VSMC was suppressed by RNAi, the proliferation of VSMC was descended and the switch from Contractil phenotype to Synthetic phenotype was blocked. This result will be published in Cell Biochemistry and Biophysics (IF: 4.37) in a few months. l I have found a huge family( 250 persons, family tree is in appendix) of CMT, but the mutation cannt be identified with common method. Now we use whole-exon sequencing to identifies the mutations and the result will came out in a few weeks. l I also am familiar with the protocol of clinic trial and attend in some international clinic trials. These include: PROFESS(Prevention Regimen for Effectively Avoiding Second Strokes), INTERACT(Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial) ESPRIT(European stroke prevention in reversible ischemia trial)， CASTA(Cerebrolysin in patients with Acute ischemic Stroke in Asia), and et al.Now I am the member of the Ethic committee in my hospital. SELECTED PUBLICATIONS PROFESSIONAL AFFILIATIONSLABORATORY SKILLS l Intensive experience in Neuropathology and neuroimaging. In 2001, Study the method of Neuropathology under the Prof. Mageritta for 6 months. She was a neurologist in Dept. Neuropathology, UPSALA university, Sweden. In the period, I learned the method of pathology and neuropathology, include of Immunohistochemistry, Immunofluorescence，in situ hybridization and so on. In 2003, take part in a neuropathology training course hold by the neuropathological branch of CMA for one month. In 2005 and 2009, take part in the advanced neuropathology training courses for half a month each time. After these courses, I learned the pathological diagnosis of many neurological diseases. In 2009, take part in the neuroimaging training course hold by neuroimaging branch of CMA for 3 months. This course was to study the MRI diagnosis of neurological disease, which include of cerebral vascular disease, cerebral tumor and Degeneration. I can read cerebral or spinal CT scans or MR scans and make the diagnosis independently. I am familiar with the imaging changes of cerebral infarction, cerebral hemorrhage, MS, cerebral infectious disease and cerebral tumors. In my clinical practice, I have diagnosed many intractable cases by myself, which include of reversible posterior leukoencephalopathy syndrome(RPLES), Wernickes encephalopathy, Cerebral Venous Thrombosis, progressive supranuclear palsy(PSP), CreutzfeldtJakob disease(CJD), cavernous malformation, central pontine myelinolysis(CPM), extra-pontine myelinolysis(EPM), gliomatosis cerebri, primary central nervous system lymphoma(PCNSL), Tolosa-Hunt syndrome, multiple system atrophy(MSA), mitochondrial myopathy and so on. From 2006 to now , I study the MR change and genetic mutation of CADASIL. I had got more than 10 families of CADASIL. More than 50 persons in these families were detected the mutation of gene or some change in MR imaging. The article will be finished in no more than one year. l Familiar with common molecular biology technology, including PCR and RT-PaCR, SSCP, RFLP, genotyping, primer and probe design, plasmid preparation, Liposome transfection.l Bacteria, cell and tissue culture, soft agar clone formation assay, transformation, cell growth assay.LANGUAGE AND COMPUTERl Proficient in English.l Proficient in data management and presentation with MS Office, statistical analysis with SPSS. Page 5 of 5
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