B淋巴细胞dj课件

IMMUNOLOGYIMMUNOLOGYIns of immunologyB B淋巴细胞淋巴细胞 戴戴 军军 讲师讲师 医学免疫学教研室医学免疫学教研室Ins of immunopharmo & immunotha2The Journal of ImmunologyThe Journal of Immunology免疫学概述免疫学概述免疫器官免疫器官免疫分子免疫分子免疫细胞免疫细胞免疫应答免疫应答临床免疫临床免疫免疫学基本知识免疫学基本知识免疫学发展简史免疫学发展简史中枢、外周免疫中枢、外周免疫器官与组织器官与组织抗体、补体、细胞因子、白抗体、补体、细胞因子、白细胞分化抗原、细胞分化抗原、MHC分子分子B细胞、细胞、T细胞、细胞、APC、固有免疫细胞固有免疫细胞Ins of immunopharmo & immunotha3The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha4The Journal of ImmunologyThe Journal of ImmunologyB B淋巴细胞淋巴细胞Ins of immunopharmo & immunotha5The Journal of ImmunologyThe Journal of Immunology 第一节第一节 B B细胞的分化发育细胞的分化发育Ins of immunopharmo & immunotha6The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha7The Journal of ImmunologyThe Journal of Immunology BCR是表达与是表达与B细胞表面的免疫球蛋白，即膜型免疫细胞表面的免疫球蛋白，即膜型免疫球蛋白（球蛋白（mIg），），B细胞通过细胞通过BCR识别抗原，接受抗原刺激，识别抗原，接受抗原刺激，启动体液免疫应答。启动体液免疫应答。BCRIns of immunopharmo & immunotha8The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha9The Journal of ImmunologyThe Journal of Immunology重链基因重链基因轻链基因轻链基因Ins of immunopharmo & immunotha10The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha11The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha12The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha13The Journal of ImmunologyThe Journal of ImmunologyVH: 40(V)25(D) 6(J)=6000VL(k): 40(V)5(J)=200VL(l): 30(V)4(J)= 1201.9 106Ins of immunopharmo & immunotha14The Journal of ImmunologyThe Journal of Immunology+ N-+ N-核苷酸核苷酸 + +TdTTdTIns of immunopharmo & immunotha15The Journal of ImmunologyThe Journal of Immunology Ins of immunopharmo & immunotha16The Journal of ImmunologyThe Journal of Immunologypro-B cellpre-B cellpre-B cellimmature cellmature cellIns of immunopharmo & immunotha17The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha18The Journal of ImmunologyThe Journal of Immunology和和Ins of immunopharmo & immunotha19The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha20The Journal of ImmunologyThe Journal of ImmunologyImmature B cell自身抗原自身抗原克隆清除（克隆清除（clone deletionclone deletion）受体编辑（受体编辑（receptor editingreceptor editing）无能（无能（anergyanergy）Ins of immunopharmo & immunotha21The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha22The Journal of ImmunologyThe Journal of Immunology第二节第二节 B B淋巴细胞的表面分子及其作用淋巴细胞的表面分子及其作用Ins of immunopharmo & immunotha23The Journal of ImmunologyThe Journal of ImmunologyPIns of immunopharmo & immunotha24The Journal of ImmunologyThe Journal of ImmunologyYxxLx(7-12)YxxLY pY 募集募集SH2结构域的下游分子结构域的下游分子Ins of immunopharmo & immunotha25The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha26The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha27The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha28The Journal of ImmunologyThe Journal of ImmunologyBTIns of immunopharmo & immunotha29The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha30The Journal of ImmunologyThe Journal of Immunology第三节第三节 B B淋巴细胞的亚群淋巴细胞的亚群CD5CD19B-1 CellB-2 CellIns of immunopharmo & immunotha31The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha32The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha33The Journal of ImmunologyThe Journal of Immunology性质性质B-1B-1细胞细胞B-2B-2细胞细胞CD5分子表达+-更新的方式自我更新由骨髓产生自发性Ig的产生高低针对的抗原碳水化合物类蛋白质类分泌的Ig类别IgMIgGIgGIgM特异性多反应性单特异性体细胞高频突变低/无高免疫记忆少/无有Ins of immunopharmo & immunotha34The Journal of ImmunologyThe Journal of Immunology第四节第四节 B B淋巴细胞的功能淋巴细胞的功能Ins of immunopharmo & immunotha35The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo & immunotha36The Journal of ImmunologyThe Journal of ImmunologyIMMUNOLOGYIMMUNOLOGYIns of immunology思考：思考： 从从BCR的胚系基因结构和基因重排理解的胚系基因结构和基因重排理解BCR多样性多样性产生的机制。产生的机制。 理解理解B细胞表面分子与其功能的对应关系。细胞表面分子与其功能的对应关系。Ins of immunopharmo & immunotha38The Journal of ImmunologyThe Journal of Immunology