【病毒外文文献】2016 Laboratory-Confirmed Human Coronavirus Infections Among Children_ Does Type Matter_

ID WEEK 2016 POSTER ABSTRACTS 156 Laboratory Con rmed Human Coronavirus Infections Among Children Does Type Matter Susan K Sanderson DNP 1 Chris Stockmann PhD MSc 1 Andrew Pavia MD FIDSA FSHEA FPIDS 1 Carrie L Byington MD FIDSA 2 Anne J Blaschke MD PhD FIDSA FPIDS 1 Emily Thorell MD MSCI 1 Adam L Hersh MD PhD 3 E Kent Korgenski MS 4 Judy A Daly PhD 5 Krow Ampofo MD FIDSA FPIDS 1 1 Department of Pediatrics Division of Pediatric Infectious Diseases University of Utah School of Medicine Salt Lake City Utah 2 Pediatrics University of Utah Salt Lake City Utah 3 University of Utah School of Medicine Salt Lake City Utah 4 Department of Pediatrics Pediatric Clinical Program University of Utah School of Medicine and Intermountain Healthcare Salt Lake City Utah 5 Clinical Microbiology Primary Children s Hospital Salt Lake City Utah Session 46 Big Viruses in Little People Pediatric Viral Diseases Thursday October 27 2016 12 30 PM Background Human coronaviruses HCoV cause illness ranging from the com mon cold to life threatening pneumonia However the reported clinical epidemiology and burden of HCoV infection is confounded by frequent codetection with other re spiratory viruses Although different types of HCoV can be detected by laboratory test ing few data exist describing single HCoV infection by type in children Methods We conducted a retrospective cohort study of children 18 years with single HCoV detection from December 2012 to February 2016 at Primary Children s Hospital PCH Salt Lake City UT Demographic clinical and nancial data of chil dren with moderate to severe single HCoV infection hospitalized 24 hours were evaluated by HCoV type HKU1 OC43 229E NL63 Testing was performed using the FilmArray Respiratory panel BioFire Diagnostics LLC Salt Lake City UT Results Over the study period a respiratory virus wasdetected in 11 714 of 19 150 61 children undergoing respiratory viral testing at PCH with HCoV accounting for 1267 11 of detected viruses Of these single HCoV infection occurred in 534 chil dren 42 of HCoV detections comprising the study cohort 207 39 were hospi talized 24 hours The overall median age was 14 months interquartile range IQR 3 46 A chronic medical condition was present in 62 30 children with 69 33 requiring intensive careunit ICU admission and 28 14 requiring mechanical ven tilation The median length of stay LOS was 2 5 days IQR 1 5 4 7 and hospital cost was 6502 IQR 3708 14 280 table Chronic medical conditions were noted more frequently in children with HCoV NL63 32 43 compared with HCoV OC43 14 18 P 0 008 Intensive care unit admission mechanical ventilation median hospital LOS and cost were comparable among the different HCoV types Death from HCoV 3 1 was rare among children with moderate to severe single HCoV infection Conclusion Human coronavirus infection is a common cause of respiratory ill ness among children Among children with single HCoV detection 35 to 42 of each type required hospitalization for 24 hours Outcomes in children with HCoV infection alonewere comparableto eachotherand associated with a substantial clinical and economic burden for all of the HCoV Q6types Disclosures A J Blaschke BioFire Diagnostics LLC Advisor regarding risks as sociated with US Food and Drug Administration cleared products and Collaborator Consulting fee and Licensing agreement or royalty A L Hersh Merck Grant Inves tigator Research grant Some abstract images in the OFID IDWeek 2016 Abstract Supplement may be unclear In those instances it is recommended that you use the IDWeek Interactive Program Planner to view the abstract and images The Program Planner can be found here Open Forum Infectious Diseases 2016 1 S1 S1 285 The Author 2016 Published by Oxford University Press on behalf of the Infectious Diseases Society of America This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial NoDerivs licence http creativecommons org licenses by nc nd 4 0 which permits non commercial reproduction and distribution of the work in any medium provided the original work is not altered or transformed in any way and that the work is properly cited Forcommercial re use please contact journals permissions DOI 10 1093 o d ofw172 Poster Abstracts OFID 2016 1 Suppl 1 S1 Downloaded from by guest on 24 October 2019