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Click to edit Master title style,Click to edit Master text styles,Second level,Third level122,Fourth level,Fifth level,花乡沭阳 开心每一天,卒中中心建设与静脉,-,动脉桥接溶栓,Knowingis not enough;we must apply.Willing is not enough;we must do,沭阳县人民医院神经内科 陈孝东,Gord Gubitz,Peter Sandercock.BMJ 2000;320:692696,2015,年,6,月,26,日,江苏省,14,家,首批入选联盟单位,宿迁唯一,OT,师,语言治疗师,责任护士,医生,PT,师,心理治疗师,静脉溶栓,依然是主旋律,缺血性卒中发病,3h,内的患者,应给予静脉,rtPA,治疗(,0.9mg/kg,,最大剂量,90mg,)(,I,,,A,),卒中,3-4.5,小时的患者,应给予静脉,rtPA,治疗(,0.9mg/kg,,最大剂量,90mg,)(,I,,,B,),适合静脉,rtPA,溶栓的患者,其治疗获益有时间依赖性,应尽快开始。到院,-,用药时间(团注给药时间)应在,60,分钟内(,I,,,A,)(新建议),卒中起病时有痫性发作的患者,只要有证据表明遗留的神经功能缺损是继发于卒中而不是发作后现象,静脉,rtPA,是合理的。(,IIa,,,C,),Stroke.,published online January 31,2013,关键救治时间点,10,分钟,判定是否卒中,开放肘正中静脉,输生理盐水,抽血化验,检查:头部,CT,,心电图,血常规,生化,凝血象,15,分钟,神经系统检查,NIHSS,25,分钟,完成,CT,扫描,45,分钟,拿到,CT,报告,拿到所有血液化验报告,60,分钟,用上针对性治疗药物(如,rt,-PA,),牢记:时间就是大脑!,动脉溶栓,单纯动脉溶栓建议选择,r t-PA,和尿激酶,推荐,r t-PA 1 mg/min,,总剂量,不超过,40 mg,!,静脉,-,动脉桥接溶栓,颅内大血管闭塞采用单一静脉溶栓血管再通率,低,而采用单一动脉溶栓会延迟治疗时间。,理论上,静脉一动脉序贯溶栓可以解决单纯静脉溶栓再通率低的问题,又可以克服动脉溶栓治疗延迟的缺点。,1.IMS Study Investigators,Combined intravenous and intra-arterial,recanalization,for acute,ischemie,stroke,:,the interventional management of stroke,studyJ,Stroke,,,2004,,,35(4),:,904-911,2.IMS,lI,Trial Investigators,The Interventional Management of Stroke(IMS)1,StudyJ,Stroke,,,2007,,,38(7),:,2127-2135,3.Ernst R,,,Pancioli,A,Tomsick,T,,,et a1,Combined intravenous and intra,arterial recombinant tissue,plasminogen,activator in acute ischemic,strokeJ,Stroke,,,2000,,,31(11),:,2552-2557,静脉,-,动脉桥接溶栓,静脉,-,动脉桥接溶栓,静脉,-,动脉桥接溶栓,
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