消化医生说喉咽反流

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,消化医生,说,喉咽反流,北京大学人民医院消化科 冯桂建,GERD is defined as symptoms or mucosal damage produced by abnormal reflux of stomach contents into the esophagus,Laryngopharyngeal,reflux(LPR)is the back flow of gastric contents(,refluxate,)to the,laryngopharynx,and upper,aerodigestive,tract.,胃食管反流病和喉咽反流,laryngopharyngeal,reflux LPR,Gastroesophgeal,reflux,diease,GERD,Koufman JA.Laryngoscope 1991;101,427例患者,GERD:113例,LPRD 43例,无反流 164例,双反流 109例,GERD 49%合并LPRD,LPRD 70%合并GERD,冯桂建等，APDW2009,发病机制,食管动力学,咽部屏障,食管上段异位胃粘膜,诊断手段,反流症状指数,(,RSI),反流体征积分,(,RSF),反流客观证据监测,(,pH,监测,/,阻抗监测,）,反流症状指数,Belafsky PC,Symptoms and findings of laryngopharyngeal reflux.Ear Nose Throat J 2002;81(Suppl 2):1013,反流体征积分,Belafsky PC，Laryngoscope，2001,反流事件的定义,病理性反流的定义,反流次数,反流面积指数,pH值监测,Characters of acid reflux in LPRD,RSI and pH test,pH test,Negative,Positive,Total,RSI,Negative,8,2,10,Positive,6,15,21,Total,14,17,31,Kappa=0.446,P=0.007;McNemar Test P=0.289,Feng GJ,Nat Med J Chin,2008,88(12):805-808,专用的口咽部pH监测仪器,电极：,RTC,公司,提供,mean,25,th,median,75,th,95,th,%time pH 4,Upright,0,0,0,0,0,Supine,0,0,0,0,0,Total,0,0,0,0,0,%time pH 4.5,Upright,0.072,0,0,0.1050,0.4000,Supine,0.126,0,0,0.0200,1.1800,Total,0.085,0,0,0.0775,0.5700,%time 14,Pre post,RSI 25.45 16.52,RSF 10.37 5.5,Ogut F,S.Surg Endosc.2007 Apr;21(4):549-54,.,我们正在组织撰写有关喉咽反流的专著，恭请各位专家赐稿。,THANK YOU,