wi原理及临床应用课件

The First Affiliated Hospital Zhejiang Chinese Medical University SWISWI的原理及临床应用的原理及临床应用2016-12-02SWI的原理及的原理及临临床床应应用用2016-12-02The First Affiliated Hospital Zhejiang Chinese Medical University SWI成像原理简介SWI的临床应用SWI成像原理成像原理简简介介The First Affiliated Hospital Zhejiang Chinese Medical University SWI成像原理SWI是一种利用不同组织间的磁敏感性差异而成像的技术，对小静脉、微出血和铁沉积更敏感。成像基础：组织间磁敏感度差异SWI成像原理成像原理SWI是一种利用不同是一种利用不同组织间组织间的磁敏感性差异而成像的磁敏感性差异而成像The First Affiliated Hospital Zhejiang Chinese Medical University SWI成像原理以T2*加权梯度回波序列作为序列基础，分别采集强度数据和相位数据的方式，并在此基础上进行数据的后处理，可将处理后的相位信息叠加到强度信息上，更加强调组织间的磁敏感性差异，形成最终的SWI图像SWI成像原理以成像原理以T2*加加权权梯度回波序列作梯度回波序列作为为序列基序列基础础，分，分别别采集采集The First Affiliated Hospital Zhejiang Chinese Medical University 与SWI相关的组织磁敏感性特点血红蛋白及其降解产物氧合血红蛋白：Fe2+与氧结合，没有不成对的电子，为反磁性去氧血红蛋白：带有4个不成对的电子，顺磁性正铁血红蛋白：血红蛋白进一步氧化为，含5个不成对电子，具有较强顺磁性，但磁敏感性较弱，主要缩短T1弛豫时间含铁血黄素：高度顺磁性，磁敏感性较强与与SWI相关的相关的组织组织磁敏感性特点血磁敏感性特点血红红蛋白及其降解蛋白及其降解产产物物The First Affiliated Hospital Zhejiang Chinese Medical University 非血红蛋白铁及钙化的磁敏感性非血红蛋白铁在体内以铁蛋白常见，为高度顺磁性。正常人随年龄增加，铁在脑内沉积增加，但在某些神经变性疾病中，如帕金森病、阿尔茨海默病等，铁异常沉积钙化：在脑内的结合状态是弱反磁性，但大多数情况下可以产生局部磁场，导致信号去相位，造成T2*缩短，信号减低非血非血红红蛋白蛋白铁铁及及钙钙化的磁敏感性化的磁敏感性The First Affiliated Hospital Zhejiang Chinese Medical University SWI的影像对比：用于小静脉显像SWI的影像的影像对对比：用于小静脉比：用于小静脉显显像像The First Affiliated Hospital Zhejiang Chinese Medical University 无论顺磁性物质还是反磁性物质，只要能改变局部磁场，导致空间相位的改变，就能产生信号的去相位，造成T2*时间缩短。去相位的结果不取决于物质是顺磁性还是反磁性，而取决于物质在一个体素内能多大程度地改变磁场无无论顺论顺磁性物磁性物质还质还是反磁性物是反磁性物质质，只要能改，只要能改变变局部磁局部磁场场，导导致空致空间间相相The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及原理及临临床床应应用用课课件件The First Affiliated Hospital Zhejiang Chinese Medical University SWI的临床应用血管源性病变肿瘤性病变颅脑外伤神经退行性疾病其他SWI的的临临床床应应用血管源性病用血管源性病变变The First Affiliated Hospital Zhejiang Chinese Medical University 血管源性病变血管源性病变海绵状血管瘤动静脉畸形毛细血管扩张症淀粉样脑血管病（CAA）脑梗死及出血血管源性病血管源性病变变血管源性病血管源性病变变The First Affiliated Hospital Zhejiang Chinese Medical University 左侧小脑海绵状血管瘤合并出血左侧小脑海绵状血管瘤合并出血左左侧侧小小脑脑海海绵绵状血管瘤合并出血状血管瘤合并出血The First Affiliated Hospital Zhejiang Chinese Medical University 多发出血的海绵状血管瘤多发出血的海绵状血管瘤多多发发出血的海出血的海绵绵状血管瘤状血管瘤The First Affiliated Hospital Zhejiang Chinese Medical University 血管畸形血管畸形血管畸形血管畸形The First Affiliated Hospital Zhejiang Chinese Medical University 右额叶深部血管发育畸形右额叶深部血管发育畸形右右额额叶深部血管叶深部血管发发育畸形育畸形The First Affiliated Hospital Zhejiang Chinese Medical University 右枕叶静脉畸形右枕叶静脉畸形右枕叶静脉畸形右枕叶静脉畸形The First Affiliated Hospital Zhejiang Chinese Medical University 左侧顶枕叶动静脉畸形左侧顶枕叶动静脉畸形左左侧顶侧顶枕叶枕叶动动静脉畸形静脉畸形The First Affiliated Hospital Zhejiang Chinese Medical University 左侧大脑半球静脉发育畸形左侧大脑半球静脉发育畸形左左侧侧大大脑脑半球静脉半球静脉发发育畸形育畸形The First Affiliated Hospital Zhejiang Chinese Medical University 放射性毛细血管扩张症放射性毛细血管扩张症放射性毛放射性毛细细血管血管扩张扩张症症The First Affiliated Hospital Zhejiang Chinese Medical University 淀粉样脑血管病淀粉样脑血管病淀粉淀粉样脑样脑血管病血管病The First Affiliated Hospital Zhejiang Chinese Medical University 淀粉样脑血管病淀粉样脑血管病CAA淀粉淀粉样脑样脑血管病血管病CAAThe First Affiliated Hospital Zhejiang Chinese Medical University MIP SWI CT左侧基底节区梗死左侧基底节区梗死 合并微小出血灶合并微小出血灶MIP SWI The First Affiliated Hospital Zhejiang Chinese Medical University 肿瘤性病变肿瘤性病变SWI可以显示肿瘤的边界、静脉、出血及钙化等肿肿瘤性病瘤性病变肿变肿瘤性病瘤性病变变The First Affiliated Hospital Zhejiang Chinese Medical University T1-CEFlairSWIT1-CEFlairSWIThe First Affiliated Hospital Zhejiang Chinese Medical University SWIT1-CE胶质瘤合并出血胶质瘤合并出血SWIT1-CE胶胶质质瘤合并出血瘤合并出血The First Affiliated Hospital Zhejiang Chinese Medical University 右侧脑室肿瘤静脉分布和出血灶右侧脑室肿瘤静脉分布和出血灶右右侧脑侧脑室室肿肿瘤静脉分布和出血灶瘤静脉分布和出血灶The First Affiliated Hospital Zhejiang Chinese Medical University 颅脑外伤性疾病颅脑外伤性疾病弥漫性轴索损伤（DAI）外伤性脑出血及梗死颅脑颅脑外外伤伤性疾病性疾病颅脑颅脑外外伤伤性疾病性疾病The First Affiliated Hospital Zhejiang Chinese Medical University 颅脑外伤性疾病弥漫性轴索损伤DAI颅脑颅脑外外伤伤性疾病弥漫性性疾病弥漫性轴轴索索损伤损伤DAIThe First Affiliated Hospital Zhejiang Chinese Medical University 弥漫性轴索损伤DAI弥漫性弥漫性轴轴索索损伤损伤DAIThe First Affiliated Hospital Zhejiang Chinese Medical University 弥漫性轴索损伤弥漫性轴索损伤DAI弥漫性弥漫性轴轴索索损伤损伤DAIThe First Affiliated Hospital Zhejiang Chinese Medical University 外伤后右侧额叶微小出血灶外伤后右侧额叶微小出血灶外外伤伤后右后右侧额侧额叶微小出血灶叶微小出血灶The First Affiliated Hospital Zhejiang Chinese Medical University 神经退行性疾病神经退行性疾病以脑内铁质沉积增多为特征Alzheimers diseaseParkinsons disease钙质沉积神神经经退行性疾病神退行性疾病神经经退行性疾病退行性疾病The First Affiliated Hospital Zhejiang Chinese Medical University Alzheimers disease齿状核铁质含量增高齿状核铁质含量增高Alzheimers diseaseThe First Affiliated Hospital Zhejiang Chinese Medical University Parkinsons disease黒质区燕尾征消失黒质区燕尾征消失Parkinsons diseaseThe First Affiliated Hospital Zhejiang Chinese Medical University wi原理及原理及临临床床应应用用课课件件The First Affiliated Hospital Zhejiang Chinese Medical University 钙化性疾病双侧苍白球钙化双侧苍白球钙化钙钙化性疾病双化性疾病双侧苍侧苍白球白球钙钙化化The First Affiliated Hospital Zhejiang Chinese Medical University 钙化性疾病少突胶质细胞瘤钙化斑少突胶质细胞瘤钙化斑钙钙化性疾病少突胶化性疾病少突胶质细质细胞瘤胞瘤钙钙化斑化斑The First Affiliated Hospital Zhejiang Chinese Medical University 其他疾病肝豆状核变性肝豆状核变性其他疾病肝豆状核其他疾病肝豆状核变变性性The First Affiliated Hospital Zhejiang Chinese Medical University wi原理及原理及临临床床应应用用课课件件The First Affiliated Hospital Zhejiang Chinese Medical University Thank You!Thank You!wi原理及临床应用课件原理及临床应用课件