儿科学教学课件：【9】小儿血液系统疾病

g/L高限高限低限低限National estimates of anaemia for the year 2011-Country estimates for children aged 659 months-2015 WHONational estimates of anaemia for the year 2011-Country estimates for children aged 659 months-2015 WHOCountryMean bloodPercentage of childrenhaemoglobinwith blood haemoglobinconcentration(g/L)concentration 110 g/LEstimate95%CIEstimate95%CIChina 121113 to 129196 to 38Japan 121113 to 126155 to 39Republic of Korea(the)121114 to 126155 to 33France 122113 to 127145 to 37Germany 122113 to 127145 to 36United Kingdom of Great Britain 122114 to 126135 to 33and Northern Ireland(the)United States of America124122 to 12565 to 12India 106101 to 1125940 to 72Afghanistan 111102 to 1214420 to 69Central African Republic 10092 to 1087252 to 84%35.9%7.8%5%2%体内铁含量体内铁含量新生儿男性女性mg35mg/kg50mg/kg75mg/kg体内铁来源体内铁来源90%70%10%30%0%20%40%60%80%100%成人成人小儿小儿内源铁外源铁。ALLANLLCML其他其他前体前体B-ALL胸腺前期胸腺早期胸腺中期胸腺晚期循环T细胞TCR重排 TCR重排CD7CD7+CD5CD5+CD2CD2+CD1CD1+CD4CD4+CD4+/-CD8CD8+CD8-/+CD3CD3+T细胞系ALL免疫表型N Engl J Med 2004;350:1535-48 N Engl J Med 2004;350:1535-48 The 2008 revision of WHO classification ofmyeloid neoplasms and acute leukemia n对诱导缓解治疗失败对诱导缓解治疗失败(诱导治疗第诱导治疗第33天天骨髓未达完全缓解骨髓未达完全缓解)nt(4；11)(q21；q23)MLL-AF4阳性、阳性、nt(9；22)(q34；q11)BCR-ABL阳性阳性n骨髓复发骨髓复发St.Jude Childrens Research Hospital from 1962 to 2005.N Engl J Med 2006;354:166-78watch and wait